-
The role of IL-18 in health and disease(Post)
Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...
IL-10 signalling and regulation(Post)Explore the complexities of Interleukin-10 (IL-10) signaling and regulation, a crucial aspect in immune response modulation and its dual roles in cancer development and therapy. Key Takeaways ...
Targeting IL-10R: Enhancing Immune Activation in Cancer(Post)Introduction to IL-10R and Immune Suppression in CancerThe interleukin-10 receptor (IL-10R) is a key player in regulating immune responses, particularly in suppressing inflammation and m ...
Physiological Roles for IL-33 | Assay Genie(Post)By Charlotte O'Donnell PhD A role for IL-33 in Barrier Function and Epithelial Wound Healing ...
Physiological and Pathological functions of IL-36(Post)By Charlotte O'Donnell PhD Similar to IL-33, IL-36R ligands are involved in maintaining intestinal homeostasis. Analogous to IL-33, d is local ...
The IL-36 Subfamily | Expression, Function & Regulation(Post)By Charlotte O'Donnell PhD The genes of the IL-36 family members are located in a cluster on chromosome 2 [1]. All three activating ligands, IL-36α, IL-36β ...
IL-9 Signaling and Its Impact on Immune Cell Regulation(Post)Interleukin-9 (IL-9) plays a critical role in the immune system, influencing a variety of biological functions across different immune cell types. This article provides an in-depth look at the si ...
Brodalumab: A Breakthrough in IL-17 Receptor Blockade for Psoriasis and Beyond(Post)Quick Facts About BrodalumabWhat is Brodalumab?Brodalumab is a monoclonal antibody that targets the IL-17 receptor to treat immune-mediated conditions like moderate-to-severe plaque pso ...
Pathological functions of IL-33/ST2 in IBD and Cancer(Post)By Charlotte O'Donnell PhD ...
Siltuximab: Exploring IL-6 Inhibition in Castleman’s Disease and Research(Post)Quick Facts About SiltuximabWhat is Siltuximab?Siltuximab is a monoclonal antibody targeting interleukin-6 (IL-6), a cytokine involved in inflammation and immune regulation.What is the ...
Interleukin 12 (IL-12) in COVID-19 Vaccines(Post)Interleukin 12 in COVID-19 Prophylactics Interleukin 12 is a cytokine with wide-reaching effects in the innate and adaptive immune system. O ...
IL-1 Family Signaling: Unraveling the Molecular Orchestra of Immune Regulation(Post)The Interleukin-1 (IL-1) family represents a crucial group of signaling molecules that play a pivotal role in regulating the immune system and inflammatory responses. Comprising 11 members, in ...
The Intricacies of IL-21 Signaling: Impact on Diverse Immune Cell Types(Post)Interleukin-21 (IL-21) stands out as a pivotal cytokine in the complex network of immune system communication. Its role in regulating various immune cell types has drawn considerable attention ...
4-1BB: Energizing Immune Cells to Overcome Tumor Resistance(Post)Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic re ...
Oct-4 Stem Cells(Post)Oct-4 stem cells, also known as Octamer-binding transcription factor 4 stem cells, are a fascinating area of study in the field of stem cell research. These stem cells hold great promise d ...
Anti-CTLA-4 Immunotherapy(Post)CD Markers Cluster of Differentiation (CD) markers play an important role in the differentiation of B cells, T cells and NK (natural killer) c ...
Anti-CTLA-4: Unleashing the Power of T Cells in Combination Immunotherapy(Post)Immunotherapy has revolutionized cancer treatment by harnessing the body's immune system to fight malignancies. Among the notable advancements in this field is the development of immune ...
Dupilumab: Transforming Immunotherapy and Skin Disease Management(Post)What You Need to Know About DupilumabWhat is Dupilumab?Dupilumab is a fully human monoclonal antibody designed to treat various chronic inflammatory diseases by inhibiting key cytokines ...
Ipilimumab and Nivolumab: Advancing Research on CTLA-4 in Cancer Therapy(Post)What You Need to Know About IpilimumabWhat is Ipilimumab?Ipilimumab is a monoclonal antibody that targets CTLA-4, a protein involved in downregulating the immune system, to boost the bo ...
The Rat Effectively Models Signature Cytokines of T Helper Cells(Post)Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly i ...
ST2 and IL33(Post)ST2, a member of the IL-1R Subfamily ST2 is a member of the IL-1R subfamily and was identified in 1989 [1]. The ST2 gene is located on chromos ...
Th17 Cell Differentiation: Insights into Immunological Dynamics(Post)Th17 cells, a subset of T helper cells characterized by their production of interleukin-17 (IL-17), play a significant role in the immune system's response to pathogens and in the pathology of a ...
Interferons(Post)Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...
Canakinumab: Unraveling Its Role in Inflammatory Disease and Cancer Research(Post)Quick Facts About CanakinumabWhat is Canakinumab?Canakinumab is a human monoclonal antibody that targets interleukin-1 beta (IL-1β), reducing inflammation associated with various diseas ...
CD25 and Tregs: Understanding the Role of Regulatory T Cells in Tumor Immunity(Post)Regulatory T cells (Tregs) play a crucial role in maintaining immune balance by suppressing excessive immune responses that could lead to tissue damage. However, in the context of cancer ...
CD4+ T Cells: Unveiling the Role of Helper and Regulatory T Cells(Post)CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...
The role of key Interleukins(Post)Interleukin signaling is involved in a number of biological processes, including cell growth and differentiation, inflammation and immunity. Interleukins are glycoproteins which act on hem ...
Growth Factors: Key Players in Biological Processes(Post)Growth factors play a vital role in the complex web of biolog ...
Biomarkers & Inflammatory markers of atherosclerosis(Post)As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis rel ...
T Cell Types, Activation, Polarization & Function(Post)T Cell Types, Activation, Polarization & Function A comprehensive guide to T cells! window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); wi ...
Innate Lymphoid Cells Differentiation: Guardians of Immune Homeostasis(Post)Innate Lymphoid Cells (ILCs) represent a fascinating component of the immune system, playing a crucial role in maintaining tissue homeostasis and mounting rapid responses against pathogens. Th ...
Tumour Inflammation & Signaling | Assay Genie(Post)By Charlotte O’Donnell PhD Inflammation and Cancer The link between inflammation and cancer is well established, with inf ...
Fezakinumab: Exploring Its Mechanism and Clinical Potential(Post)Quick Facts About FezakinumabWhat is Fezakinumab?Fezakinumab is a human IgG1-lambda monoclonal antibody that targets interleukin-22 (IL-22), a cytokine involved in inflammatory response ...
Dendritic Cells - Markers, Activation & Subtypes(Post)Exploring the multifaceted role of dendritic cells in immune function and disease. Key Takeaways DCs are professional antigen-presenting cells that capture, process, and pres ...
NK Cells: Unlocking the Potential of Natural Killer Cells in Cancer Therapy(Post)Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill canc ...
Macrophage, M1 & M2, Polarization and Function(Post)What is a Macrophage? Macrophages are indeed a type of phagocyte, responsible for engulfing and destroying foreign particles and cellular debris. They are larger cells with more cytoplasm a ...
Interleukin-8 signalling(Post)IL-8 Overview Interleukin-8 (IL-8), also known as CXCL8, was discovered over 30 years ago as a small molecule that could ...
Biosimilar: Expanding Access to Monoclonal Antibody-Based Therapies(Post)1. What is a Biosimilar? A biosimilar is a biologic medical product that is highly similar to an already-approved reference biologic. While minor differences in clinically inactive ...
BDNF in inflammation and neuropathologies(Post)BDNF Overview Brain-derived neurotrophic factor (BDNF) is a central mediator of neuroplasticity, a term used to describe the ability of neuron ...
Basiliximab: Mechanism, Clinical Applications, and Research Advancements(Post)Quick Facts About BasiliximabWhat is Basiliximab?Basiliximab is a monoclonal antibody targeting the CD25 subunit of the IL-2 receptor, primarily used to prevent organ transplant rejecti ...
Test Rapido Punto Di Cura COVID-19 - Solo per la Ricerca(Post)TEST RAPIDO POC COVID-19 Descrizione Il kit Assay Genie solo utilizzo per la ricerca. Il kit rapido C ...
Inflammasome Activation Pathways: A Comprehensive Overview(Post)Inflammasomes are complex intracellular structures that play a pivotal role in the immune response by detecting pathogenic microorganisms and sterile stressors. Their activation is a critical ste ...
EGF Family (Post)Epidermal Growth Factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor epidermal growth factor receptor (EGFR) which triggers ligand-induced ...
CD122: Fine-Tuning T Cell Responses in Immunotherapy(Post)Introduction to CD122 in Immunotherapy CD122, also known as the interleukin-2 receptor beta chain (IL-2Rβ), is a critical component of the immune system's response to pathogens and ...
Tocilizumab (Actemra®) in COVID-19 Treatment(Post)Tocilizumab (Actemra®) in COVID-19 Treatment What is Tocilizumab? Tocilizumab, also called atlizumab, is an immunosuppres ...
ILC2: The Immune Cell That Fights Allergies and Infections(Post)ILC2 - Function, Cytokines, and Role in Health and Disease A quick guide to IL2C ...
CXCL16 – Review(Post)CXCL16 CXCL16, a unique member of the CXC chemokine family, stands at the crossroads of immune modulation and vascular biology. Initially discovered as a che ...
Sensing Danger: The Biology of TLR-Mediated Inflammation(Post)By Eoin Mac Réamoinn Toll-like receptors (TLRs) are renowned for their fundamental roles in innate sensing and initiating inflammatory responses. TLR ...
ICOS: Stimulating the Immune System for Superior Cancer Therapy(Post)Immunotherapy has transformed the landscape of cancer treatment by leveraging the body’s immune system to target and destroy cancer cells. A key player in this process is Inducible T-cel ...
COVID-19 Biomarkers(Post)SARS-CoV-2 Background COVID-19 is characterised by a series of biological markers. In some instances, these biomarkers can be used as potent ...
Guide to Understanding Th1 and Th2 Cells(Post)window.SHOGUN_IMAGE_V2_ELEMENTS = window.SHOGUN_IMAGE_V2_ELEMENTS || new Array(); window.SHOGUN_IMAGE_V2_ELEMENTS.push({ uuid: 's-19118a5d-7dea-4fc9-8267-6237960845ca' }) The T ...
Targeting VISTA: Unleashing the Power of T Cells in Cancer Therapy(Post)V-domain Ig suppressor of T cell activation (VISTA) is an emerging immune checkpoint receptor that plays a key role in suppressing T cell activity within the tumor microenvironment (TME) ...
Nod-Like Receptor Signaling Pathway: A Keystone in Innate Immunity(Post)The innate immune system, a primary line of defense against pathogens, comprises various cellular and molecular mechanisms. Among these, the Nod-like Receptor (NLR) signaling pathways play a crit ...
Immunometabolism – A therapeutic perspective(Post)What is Immunometabolism? Immunometabolism is an exponentially growing, multi-disc ...
C reactive protein(Post)Delve into the world of C-reactive protein (CRP), a critical player in the body's response to inflammation, and understand its role in health and disease. Key Takeaways C-reacti ...
Kit di Estrazione DNA RNA Virus (Post)Kit di Estrazione DNA/RNA Virus Il Kit di Estrazione dell'Acido Nucleico Virale II è stato progettato specificamente per la purificazione efficiente del DNA virale e dell'RNA vir ...
Macrophage Activation: A Keystone in Immune Response and Therapeutic Potential(Post)In the intricate tapestry of the immune system, macrophages play a pivotal role, orchestrating a wide range of biological responses that protect the body against pathogens, remove cellular debris ...
Neuroimmunology: The Immune System of the CNS(Post)What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to ...
TLR4: Unraveling the Role of Inflammation in Cancer Progression(Post)Introduction to TLR4 and Cancer Toll-like receptor 4 (TLR4) is a key component of the innate immune system, primarily responsible for detecting infections and initiating inflammator ...
Freezing Stimulated T Cells: A Detailed Guide(Post)Cryopreservation of stimulated T cells is a common technique in immunology research, allowing for long-term storage while maintaining their functional viability. Stimulated T cells—espec ...
OX40 Agonists: Revitalizing the Immune Response in Cancer(Post)Cancer immunotherapy has revolutionized treatment options, offering strategies to harness the immune system to target and destroy tumors. One emerging area of interest is the use of OX40 ...
Adhesion molecules in atherosclerosis – ICAM1(Post)Adhesion Molecules Direct cell-cell interactions are maintained and regulated by cell adhesion molecules. The expression of adhesion molecule ...
Understanding T Cell Fatigue: Implications for Immune Function and Therapeutic Interventions(Post)T cells are central players in adaptive immunity, responsible for recognizing and eliminating infected or aberrant cells. Upon encountering antigens, T cells undergo clonal expansion and diffe ...
SOCS proteins: Manipulating the immune response(Post)Katherine Edwards, PhD Student, Queen’s University Belfast Cytokines play a vital role in immune responses enabling cross-talk between different cell types ...
IL-10 신호 및 규제(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "IL-10 신호 및 규제", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublish ...
IL-1 Family Proteins(Page)The interleukin 1 (IL-1) family is a group that consists of 11 cytokines that plays an essential role in the regulation of immune and inflammatory response to infectio ...
IL-6 개요(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "IL-6 개요", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublished" : ...
IL-10 Family Proteins(Page)IL-10 (Interleukin-10) is a family of interleukins including IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28 and IL-29. The IL-10 family proteins are all members of the class II cytokine r ...
IL-6 Family Proteins(Page)The IL-6 family consists of nine cytokines, IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM), leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNF), cardio ...
Multiplex Premixed Panels(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-08a0a ...
Human Multiplex Inflammation ELISA Panels(Page)The ELISA Genie, Human Inflammation multiplex assays utilizes multiple bead populations differentiated by size and different levels of fluorescence intensity. With multiple sizes of bea ...
Mouse Multiplex ELISA Panels(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-6747133c-26 ...
Human Multiplex ELISA Panels(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-5c77c8b5-9a ...
Customer Validated Multiplex Panels(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', ...
PharmaGenie ELISA Kits(Page)PharmaGenie ELISA Validated According to ISO Quality Systems ...
ELISpot Assay Kits(Page)ELISpot 400x more sensitive than ELISA! Detection & Visualisation at the Single-Cell Leve ...
ELISA Sampler Packs(Page)ELISA Sampler Packs Based on thousands of citations and years of scientific endeavour, Assay Genie h ...
ELISA Kits(Page)Key Interleukin, Chemokine and Cytokine targetsCytokine ELISA KitsFIND OUT MOREMultiplex up to 24 targetsMultiplex AssaysFIND OUT MOREImmuno-oncology and Immuno drug monitoringTherapeut ...
Non-Human Primate Multiplex ELISA Panels(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-2dc821cd-c5c ...
High Sensitivity Cytokine ELISA Kits & Multiplex Panels(Page)High Sensitivity Cytokine ELISA Cytokine ELISA Kits & Multiplex ...
Rat Multiplex ELISA Panels(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-08000e48-13 ...
Adipocytokines(Page)Adipocytokines or adipokines are bioactive molecules that are produced by adipose tissue. They comprise cytokines, chemokines coagulation factors and factors involved ...
COVID-19 Cytokine Storm Multiplex Assays(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-d7cc806f-05 ...
Canine Multiplex ELISA Panels(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-15cace94-25b ...
코비드-19 사이토카인 방출 증후군(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "코비드-19 사이토카인 방출 증후군", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "dateP ...
Biosimilar Antibodies(Page)Biosimilar AntibodiesFunctional-grade biosimilars for in vitro and in vivo experiments, validated to support innovation in drug discovery, molecular biology, and cell-based assays!Searc ...
Inflammatory Cytokines Function & Release(Page)Cytokines are essential communicators in the immune system, orchestrating cell interactions and responses to maintain balance and combat diseases. Key Takeaways Cytokines are small prote ...
In Vivo Functional Grade Antibodies(Page)Functional Grade In Vivo Antibodies Our low endotoxin mAbs for translational and preclinical animal studies are more efficacious and cost effective than competitors! Explore ...
Mouse Multiplex Inflammation ELISA Panels(Page)The ELISA Genie, Mouse inflammation multiplex assays utilizes multiple bead populations differentiated by size and different levels of fluorescence intensity. With multiple sizes of bea ...
Pre-clinical & Large Animal Antibodies(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-90226c4c-be ...
인터루킨 8 시그널링(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "인터루킨 8 시그널링", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublished ...
PharmaGenie ELISA キット(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "PharmaGenie ELISA キット", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "dat ...
Chemokines(Page)Chemokines Key Research Areas C Chemokine Ligands XCL1/Lymphot ...
Animal DIY ELISA Kits(Page)Animal DIY ELISA Kits Maximise your research budget! Animal DIY (Do-It-Yourself) ELISA kits a ...
Test rapido combinato per gli antigeni di COVID-19 e influenza di tipo A/B (tampone nasofaringeo)(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "Test rapido combinato per gli antigeni di COVID-19 e influenza di tipo A/B (tampone nasofaringeo)", "aut ...
ELISA 분석법, 원리, 프로토콜, 방법 및 키트(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "ELISA 분석법, 원리, 프로토콜, 방법 및 키트 | Elisa Genie", "author" : { "@type" : "Person", "name" : "Seán M ...
Adipokines(Page)Adipokines/Adipocytokines Adipokines are cytokines thata have been released from adipose tissue to regulate inflammatin and homeostasis.
Sistema di Trasporto Virale con MTM – Tampone Faringeo Generico(Page)Skip to main content Edit a Web Page To create a web page (such as an "About Us" page or a contact form), start by choosing the type of page you want and then fill in the other details. Page Type Thi ...
샌드위치 엘리사(Page){ "@context" : "http://schema.org", "@type" : "Article", "name" : "샌드위치 엘리사", "author" : { "@type" : "Person", "name" : "Seán Mac Fhearraigh PhD" }, "dateP ...
Top 10 Therapeutics(Page)window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-6ebebd0d- ...