SENP1 Rabbit Monoclonal Antibody (CAB4460)

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CAB4460
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Description

Technical Manual

SENP1 Rabbit Monoclonal Antibody

Product Name:SENP1 Rabbit Monoclonal Antibody
Product SKU:CAB4460
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Immunogen:A synthesized peptide derived from human SENP1
Sequence:

Email for sequence

Gene ID:29843
Swiss Prot:Q9P0U3
Synonyms:SuPr-2
Calculated MW:73kDa
Observed MW:73KDa
Reactivity:Human
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:HeLa, PC-3
Cellular Location:

Product Images

SENP1 Rabbit Monoclonal Antibody (CAB4460)

Western blot - SENP1 Rabbit mAb (CAB4460)

Uniprot Information

UniProt Protein Function:SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.22.68; Protease; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus

Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity

Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis

NCBI Summary:This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
UniProt Code:Q9P0U3
NCBI GenInfo Identifier:215273882
NCBI Gene ID:29843
NCBI Accession:Q9P0U3.2
UniProt Secondary Accession:Q9P0U3,Q86XC8, A8K7P5,
UniProt Related Accession:Q9P0U3
Molecular Weight:73,351 Da
NCBI Full Name:Sentrin-specific protease 1
NCBI Synonym Full Names:SUMO1/sentrin specific peptidase 1
NCBI Official Symbol:SENP1 
NCBI Official Synonym Symbols:SuPr-2 
NCBI Protein Information:sentrin-specific protease 1
UniProt Protein Name:Sentrin-specific protease 1
UniProt Synonym Protein Names:Sentrin/SUMO-specific protease SENP1
Protein Family:Sentrin-specific protease
UniProt Gene Name:SENP1 
UniProt Entry Name:SENP1_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
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