Description
TEAD3 Transcription Factor Activity Assay
The TEAD3 Transcription Factor Activity Assay Kit is a cutting-edge tool for studying the activity of TEAD3, a key transcription factor involved in gene regulation. This assay kit offers high sensitivity and specificity, allowing for precise measurements of TEAD3 activity in cell lysates and tissue samples.TEAD3 is a critical transcription factor that plays a pivotal role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of TEAD3 activity has been implicated in numerous diseases, such as cancer and cardiovascular disorders, highlighting the importance of studying its function.
With the TEAD3 Transcription Factor Activity Assay Kit, researchers can gain valuable insights into the role of TEAD3 in disease pathogenesis and potential therapeutic interventions. Its user-friendly protocol and reliable results make it an essential tool for unlocking the mysteries of TEAD3 biology.
| Product Name: | TEAD3 Transcription Factor Activity Assay |
| Product Code: | TFAB00175 |
| Target: | TEAD3 |
| Synonyms: | DTEF-1, TEA domain family member 3, TEAD-3 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie TEAD3 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21.2 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription factor activity Biological Process: asymmetric neuroblast division; female pregnancy; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99594 |
| NCBI GenInfo Identifier: | 2501157 |
| NCBI Gene ID: | 7005 |
| NCBI Accession: | Q99594.2 |
| UniProt Secondary Accession: | Q99594,O95910, Q5BJG7, Q8N6Y4, |
| UniProt Related Accession: | Q99594 |
| Molecular Weight: | 48,676 Da |
| NCBI Full Name: | Transcriptional enhancer factor TEF-5 |
| NCBI Synonym Full Names: | TEA domain transcription factor 3 |
| NCBI Official Symbol: | TEAD3 |
| NCBI Official Synonym Symbols: | TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3 |
| NCBI Protein Information: | transcriptional enhancer factor TEF-5 |
| UniProt Protein Name: | Transcriptional enhancer factor TEF-5 |
| UniProt Synonym Protein Names: | DTEF-1; TEA domain family member 3; TEAD-3 |
| Protein Family: | Transcriptional enhancer factor |
| UniProt Gene Name: | TEAD3 |
| UniProt Entry Name: | TEAD3_HUMAN |
