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Anti-UBE2B Antibody (CAB0503)

SKU:
CAB0503
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
UBE2B
E2-17kDa
HHR6B
HR6B
RAD6B
UBC2
ubiquitin-conjugating enzyme E2 B
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

Product Name:UBE2B Rabbit mAb
Product Code:CAB0503
Size:20uL, 50uL, 100uL
Synonyms:UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin-conjugating enzyme E2 B
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human UBE2B.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, NIH/3T3, K-562, Mouse testis, Mouse heart, Rat testis
Immunogen:A synthesized peptide derived from human UBE2B.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7320
Uniprot:P63146
Cellular Location:Cell membrane, Nucleus
Calculated MW:17kDa
Observed MW:17KDa
UniProt Protein Function:UBE2B: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.
UniProt Protein Details:

Protein type:Ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: XY body; nuclear chromatin; cytoplasm; plasma membrane; replication fork; chromatin; nucleus

Molecular Function:protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: response to drug; protein monoubiquitination; ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; protein stabilization; in utero embryonic development; postreplication repair; protein ubiquitination; Wnt receptor signaling pathway through beta-catenin; DNA repair; negative regulation of histone phosphorylation; cellular response to insulin stimulus; maintenance of chromatin silencing; response to hypoxia; sperm axoneme assembly; spermatogenesis; chiasma formation; response to DNA damage stimulus; histone H2A ubiquitination; response to UV; negative regulation of apoptosis

NCBI Summary:The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
UniProt Code:P63146
NCBI GenInfo Identifier:52783814
NCBI Gene ID:7320
NCBI Accession:P63146.1
UniProt Related Accession:P63146
Molecular Weight:
NCBI Full Name:Ubiquitin-conjugating enzyme E2 B
NCBI Synonym Full Names:ubiquitin conjugating enzyme E2 B
NCBI Official Symbol:UBE2B  
NCBI Official Synonym Symbols:HR6B; UBC2; HHR6B; RAD6B; E2-17kDa  
NCBI Protein Information:ubiquitin-conjugating enzyme E2 B
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 B
UniProt Synonym Protein Names:RAD6 homolog B; HR6B; hHR6B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2B  
UniProt Entry Name:UBE2B_HUMAN

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