Anti-FHL2 Antibody (CAB3670)
- SKU:
- CAB3670
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AAG11
- DRAL
- FHL-2
- SLIM-3
- SLIM3
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | FHL2 Rabbit mAb |
| Product Code: | CAB3670 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AAG11, DRAL, FHL-2, SLIM-3, SLIM3 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human FHL2 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart, Rat heart, SKOV3, RD |
| Immunogen: | A synthesized peptide derived from human FHL2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2274 |
| Uniprot: | Q14192 |
| Calculated MW: | 32kDa |
| Observed MW: | 32kDa |
| UniProt Protein Function: | FHL2: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 2q12.2 Cellular Component: nucleoplasm; focal adhesion; M band; nucleus; Z disc; actin cytoskeleton Molecular Function:identical protein binding; protein binding; androgen receptor binding; zinc ion binding; transcription coactivator activity; transcription factor binding Biological Process: osteoblast differentiation; atrial cardiac muscle cell development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; ventricular cardiac muscle cell development; androgen receptor signaling pathway; response to hormone stimulus; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q14192 |
| NCBI GenInfo Identifier: | 116241364 |
| NCBI Gene ID: | 2274 |
| NCBI Accession: | Q14192.3 |
| UniProt Related Accession: | Q14192 |
| Molecular Weight: | ~ 32kDa |
| NCBI Full Name: | Four and a half LIM domains protein 2 |
| NCBI Synonym Full Names: | four and a half LIM domains 2 |
| NCBI Official Symbol: | FHL2Â Â |
| NCBI Official Synonym Symbols: | DRAL; AAG11; FHL-2; SLIM3; SLIM-3Â Â |
| NCBI Protein Information: | four and a half LIM domains protein 2 |
| UniProt Protein Name: | Four and a half LIM domains protein 2 |
| UniProt Synonym Protein Names: | LIM domain protein DRAL; Skeletal muscle LIM-protein 3; SLIM-3 |
| Protein Family: | Four and a half LIM domains protein |
| UniProt Gene Name: | FHL2Â Â |
| UniProt Entry Name: | FHL2_HUMAN |
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