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Anti-WDR4 Antibody (CAB19765)

SKU:
CAB19765
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TRM82
TRMT82
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

Product Name:WDR4 Rabbit mAb
Product Code:CAB19765
Size:20uL, 50uL, 100uL
Synonyms:TRM82, TRMT82
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human WDR4
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, A-549, Mouse lung, Mouse spleen, Mouse kidney, Rat kidney
Immunogen:A synthesized peptide derived from human WDR4
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10785
Uniprot:P57081
Calculated MW:45kDa
Observed MW:73KDa
UniProt Protein Function:WDR4: a WD40 repeat protein. Required for 7-methylguanosine modification of tRNA. Forms a complex with METTL1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:protein binding; tRNA (guanine-N7-)-methyltransferase activity

Biological Process: tRNA modification

NCBI Summary:This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
UniProt Code:P57081
NCBI GenInfo Identifier:20141943
NCBI Gene ID:10785
NCBI Accession:P57081.2
UniProt Secondary Accession:P57081,Q9BVM5, Q9HCR3, A8KA58, B2RCA3, B4DNQ7, D3DSK3
UniProt Related Accession:P57081
Molecular Weight:29,946 Da
NCBI Full Name:tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
NCBI Synonym Full Names:WD repeat domain 4
NCBI Official Symbol:WDR4  
NCBI Official Synonym Symbols:TRM82; TRMT82  
NCBI Protein Information:tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
UniProt Protein Name:tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
UniProt Synonym Protein Names:WD repeat-containing protein 4
Protein Family:tRNA
UniProt Gene Name:WDR4  
UniProt Entry Name:WDR4_HUMAN

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