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APC Anti-Human CD279/PD-1 Antibody [EH12.2H7] (AGEL2724)

Datasheet MSDS
SKU AGEL2724
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG1, κ
Clone EH12.2H7
Conjugation APC
$169 - $515

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Description

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APC Anti-Human CD279/PD-1 Antibody [EH12.2H7]

The APC Anti-Human CD279 (PD-1) Antibody (EH12.2H7) offered by Assay Genie is a cutting-edge tool for researchers studying immune checkpoint proteins, particularly PD-1, which plays a key role in regulating immune responses. This monoclonal antibody specifically targets the CD279 (PD-1) protein on human cells and is suitable for a variety of applications, including flow cytometry and immunohistochemistry.PD-1, also known as programmed cell death protein 1, is a crucial component of the immune system that helps prevent T cells from attacking other cells in the body. Dysregulation of PD-1 signaling has been implicated in various diseases, including cancer and autoimmune disorders.

By using the APC Anti-Human CD279 (PD-1) Antibody (EH12.2H7), researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop targeted therapies.This antibody has been rigorously validated for its specificity and sensitivity, ensuring reliable and reproducible results in experimental settings. Its versatility and precision make it an indispensable tool for advancing research in immunology, oncology, and other related fields. Unleash the power of precision with the APC Anti-Human CD279 (PD-1) Antibody (EH12.2H7) from Assay Genie.

Product Title:APC Anti-Human CD279/PD-1 Antibody [EH12.2H7]
SKU:AGEL2724
Size:20 Tests, 100 Tests, 200 Tests
Clone No:EH12.2H7
Synonyms:PDCD1;PD1;Protein PD-1;hPD-1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q15116
Gene ID:5133
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
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