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FITC Anti-Human CD279/PD-1 Antibody [EH12.2H7] (AGEL3070)

Datasheet MSDS
SKU AGEL3070
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG1, κ
Clone EH12.2H7
Conjugation FITC
$110 - $436

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Description

system_update_altDatasheetsystem_update_altMSDS

FITC Anti-Human CD279/PD-1 Antibody [EH12.2H7]

The FITC Anti-Human CD279 (PD-1) Antibody (EH12.2H7) offered by AssayGenie is a cutting-edge research tool designed for investigating the PD-1 protein, a key immune checkpoint receptor involved in regulating T-cell responses. This monoclonal antibody, conjugated with FITC for fluorescence detection, is specifically tailored for use in flow cytometry applications targeting human samples.PD-1, also known as programmed cell death protein 1, plays a pivotal role in maintaining immune tolerance by inhibiting T-cell activation and preventing excessive immune responses that can lead to autoimmunity. Dysregulation of the PD-1 pathway is implicated in various diseases, including cancer, chronic infections, and autoimmune disorders, making it a prime target for therapeutic interventions and immunotherapy strategies.

By utilizing the FITC Anti-Human CD279 (PD-1) Antibody, researchers can accurately detect and analyze PD-1 expression on immune cells, providing valuable insights into immune dysfunction and potential therapeutic targets. This antibody is a valuable asset for studies in immunology, oncology, and autoimmune diseases, enabling in-depth exploration of the PD-1 pathway and its impact on immune regulation and disease progression.

Product Title:FITC Anti-Human CD279/PD-1 Antibody [EH12.2H7]
SKU:AGEL3070
Size:20 Tests, 100 Tests, 200 Tests
Clone No:EH12.2H7
Synonyms:PDCD1;PD1;Protein PD-1;hPD-1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:FITC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q15116
Gene ID:5133
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
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