Description
DNA Damage Response Antibody Sampler Pack (ABSP008)
The DNA Damage Response Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies covering the key nodes of this pathway in a convenient 20µL trial format. It is designed to let researchers interrogate an entire signalling axis in a single, cost-effective pack, then scale up to full-size formats for the targets that matter most to their work.
| Pack Name: | DNA Damage Response Antibody Sampler Pack |
| SKU: | ABSP008 |
| Research Area: | Cancer |
| Targets Included: | 8 |
| Format: | 8 × 20µL |
| Targets: | ATM, Phospho-ATM, ATR, Chk1, Chk2, gamma-H2AX, BRCA1, 53BP1 |
| Target | Antibody | SKU | Host | Reactivity | Applications | Size |
|---|---|---|---|---|---|---|
| ATM | Anti-ATM [ARC0129] Monoclonal Antibody | CAB19650-20 | Rabbit | Human, Mouse | WB IHC-P ELISA | 20µL |
| Phospho-ATM | Anti-Phospho-ATM-S1981 [ARC1575] Monoclonal Antibody | CABP1030-20 | Rabbit | Human | WB ELISA | 20µL |
| ATR | Anti-ATR [ARC51749] Monoclonal Antibody | CAB21253-20 | Rabbit | Human, Mouse | WB ELISA | 20µL |
| Chk1 | Anti-Chk1 Monoclonal Antibody | CAB22055-20 | Rabbit | Human | WB ELISA | 20µL |
| Chk2 | Anti-Chk2 Monoclonal Antibody | CAB19543-20 | Rabbit | Human, Mouse | WB IHC-P ELISA | 20µL |
| gamma-H2AX | Anti-Phospho-Histone H2AX-S139 [ARC0110] Monoclonal Antibody | CABP0687-20 | Rabbit | Human, Mouse, Rat | WB IHC-P IF/ICC ELISA | 20µL |
| BRCA1 | Anti-BRCA1 Antibody | CAB0212-20 | Rabbit | Human, Mouse | WB ELISA | 20µL |
| 53BP1 | Anti-53BP1 Monoclonal Antibody | CAB3859-20 | Rabbit | Human, Mouse | IHC-P IF/ICC ELISA | 20µL |
The DNA damage response is coordinated by the apical kinases ATM and ATR, which phosphorylate CHK1/CHK2 and histone H2AX (gamma-H2AX) to halt the cell cycle and recruit repair machinery including BRCA1 and 53BP1. Defects in this network underlie genomic instability and sensitivity to genotoxic therapy.
| Pack Format: | 8 antibodies, 20µL each (trial size) |
| Storage: | Store at -20°C |
| Shelf Life: | 12 months |
| Shipping: | Gel pack |
Every antibody in this sampler pack is also available individually in full 100µL size for follow-on experiments and assay scale-up.
