Fbx32 Rabbit Monoclonal Antibody (CAB3699)

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CAB3699
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Description

Technical Manual

Fbx32 Rabbit Monoclonal Antibody

Product Name:Fbx32 Rabbit Monoclonal Antibody
Product SKU:CAB3699
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Immunogen:A synthesized peptide derived from human Fbx32
Sequence:

Email for sequence

Gene ID:114907
Swiss Prot:Q969P5
Synonyms:Fbx32; MAFbx
Calculated MW:42kDa
Observed MW:42KDa
Reactivity:Mouse, Rat
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry 
Positive Samples:Mouse skeletal muscle, Rat skeletal muscle
Cellular Location:

Product Images

Fbx32 Rabbit Monoclonal Antibody (CAB3699)

Western blot - Fbx32 Rabbit mAb (CAB3699)

Uniprot Information

UniProt Protein Function:FBXO32: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: nucleolus; Z disc

Molecular Function:protein binding

Biological Process: protein ubiquitination; response to denervation involved in regulation of muscle adaptation

NCBI Summary:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
UniProt Code:Q969P5
NCBI GenInfo Identifier:20177894
NCBI Gene ID:114907
NCBI Accession:Q969P5.1
UniProt Secondary Accession:Q969P5,A4KYM0,
UniProt Related Accession:Q969P5
Molecular Weight:355
NCBI Full Name:F-box only protein 32
NCBI Synonym Full Names:F-box protein 32
NCBI Official Symbol:FBXO32 
NCBI Official Synonym Symbols:Fbx32; MAFbx 
NCBI Protein Information:F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
UniProt Protein Name:F-box only protein 32
UniProt Synonym Protein Names:Atrogin-1; Muscle atrophy F-box protein; MAFbx
UniProt Gene Name:FBXO32 
UniProt Entry Name:FBX32_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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