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Anti-GOT1 Antibody (CAB11363)

SKU:
CAB11363
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-GOT1 Antibody
Antibody SKU:CAB11363
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GOT1
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549, U-87MG, Mouse liver, Mouse brain, Mouse heart, Rat liver, Rat brain, Rat kidney
Immunogen:A synthesized peptide derived from human GOT1
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2805
Uniprot:P17174
Cellular Location:Cytoplasm
Calculated MW:46kDa
Observed MW:41KDa
Anti-GOT1 AntibodyWestern blot - GOT1 Rabbit mAb (CAB11363)
Synonyms:AST1, ASTQTL1, GIG18, cAspAT, cCAT
Background:Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
UniProt Protein Function:GOT1: Plays a key role in amino acid metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - arginine and proline; Transferase; EC 2.6.1.1; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; EC 2.6.1.3; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - alanine, aspartate and glutamate

Chromosomal Location of Human Ortholog: 10q24.1-q25.1

Cellular Component: lysosome; cytoplasm; nerve terminal; cytosol; nucleus

Molecular Function:cysteine transaminase activity; carboxylic acid binding; phosphatidylserine decarboxylase activity; aspartate transaminase activity; pyridoxal phosphate binding

Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; response to glucocorticoid stimulus; aspartate biosynthetic process; glucose metabolic process; pathogenesis; 2-oxoglutarate metabolic process; gluconeogenesis; methionine salvage; cellular response to insulin stimulus; sulfur amino acid metabolic process; glycerol biosynthetic process; fatty acid homeostasis; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; amino acid biosynthetic process; glutamate catabolic process to 2-oxoglutarate; polyamine metabolic process

Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1

NCBI Summary:Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
UniProt Code:P17174
NCBI GenInfo Identifier:5902703
NCBI Gene ID:2805
NCBI Accession:P17174.3
UniProt Secondary Accession:P17174,Q5VW80, B2R6R7, B7Z7E9,
UniProt Related Accession:P17174
Molecular Weight:Calculated MW: 44kDa/46kDaObserved MW: 46kDa
NCBI Full Name:Aspartate aminotransferase, cytoplasmic
NCBI Synonym Full Names:glutamic-oxaloacetic transaminase 1, soluble
NCBI Official Symbol:GOT1  
NCBI Official Synonym Symbols:cCAT; GIG18; cAspAT; ASTQTL1  
NCBI Protein Information:aspartate aminotransferase, cytoplasmic; transaminase A; aspartate transaminase 1; aspartate aminotransferase 1; growth-inhibiting protein 18; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; cysteine aminotransferase, cytoplasmic
UniProt Protein Name:Aspartate aminotransferase, cytoplasmic
UniProt Synonym Protein Names:Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A
Protein Family:Protein transport protein
UniProt Gene Name:GOT1  
UniProt Entry Name:AATC_HUMAN

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