Description
KLF7 Transcription Factor Activity Assay
The KLF7 Transcription Factor Activity Assay Kit is a cutting-edge tool for measuring the transcriptional activity of KLF7 in cell lysates. KLF7 is a key transcription factor that regulates gene expression and plays a critical role in various biological processes, including cell differentiation, proliferation, and development.This assay kit offers high sensitivity and specificity, allowing for accurate quantification of KLF7 activity in a variety of cell types and experimental conditions. Its user-friendly format and quick assay time make it ideal for high-throughput screening and detailed mechanistic studies.
By using the KLF7 Transcription Factor Activity Assay Kit, researchers can gain valuable insights into the regulatory mechanisms controlled by KLF7 and its impact on cellular functions. This kit is essential for investigating KLF7's role in disease progression, such as cancer, diabetes, and neurological disorders, and for developing novel therapeutic strategies targeting KLF7 activity.
| Product Name: | KLF7 Transcription Factor Activity Assay |
| Product Code: | TFAB00194 |
| Target: | KLF7 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie KLF7 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | KLF7: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence. Belongs to the krueppel C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 2q32 Cellular Component: nucleus Molecular Function:DNA binding; zinc ion binding; transcription coactivator activity; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; axon guidance; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; dendrite morphogenesis |
| NCBI Summary: | The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | O75840 |
| NCBI GenInfo Identifier: | 401709918 |
| NCBI Gene ID: | 8609 |
| NCBI Accession: | NP_001257871.1 |
| UniProt Secondary Accession: | O75840,Q7Z3H8, Q96E51, B2RB03, B7Z4F7, C9JF04, E7EWH1 L0R4P2, |
| UniProt Related Accession: | O75840 |
| Molecular Weight: | 33kd |
| NCBI Full Name: | Krueppel-like factor 7 isoform 2 |
| NCBI Synonym Full Names: | Kruppel-like factor 7 (ubiquitous) |
| NCBI Official Symbol: | KLF7 |
| NCBI Official Synonym Symbols: | UKLF |
| NCBI Protein Information: | Krueppel-like factor 7 |
| UniProt Protein Name: | Krueppel-like factor 7 |
| UniProt Synonym Protein Names: | Ubiquitous krueppel-like factor |
| Protein Family: | Krueppel-like factor |
| UniProt Gene Name: | KLF7 |
| UniProt Entry Name: | KLF7_HUMAN |
