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PARP1 Rabbit Polyclonal Antibody (CAB0010)

SKU:
CAB0010
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-PARP1 Antibody CAB0010
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-PARP1 Antibody CAB0010
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-PARP1 Antibody CAB0010
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-PARP1 Antibody CAB0010
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-PARP1 Antibody CAB0010
€139 - €419
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Description

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Product Name:PARP1 Rabbit Polyclonal Antibody
SKU:CAB0010
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 662-1014 of PARP1 (NP_001609.2).
Sequence:KSKL PKPV QDLI KMIF DVES MKKA MVEY EIDL QKMP LGKL SKRQ IQAA YSIL SEVQ QAVS QGSS DSQI LDLS NRFY TLIP HDFG MKKP PLLN NADS VQAK VEML DNLL DIEV AYSL LRGG SDDS SKDP IDVN YEKL KTDI KVVD RDSE EAEI IRKY VKNT HATT HNAY DLEV IDIF KIER EGEC QRYK PFKQ LHNR RLLW HGSR TTNF AGIL SQGL RIAP PEAP VTGY MFGK GIYF ADMV SKSA NYCH TSQG DPIG LILL GEVA LGNM YELK HASH ISKL PKGK HSVK GLGK TTPD PSAN ISLD GVDV PLGT GISS GVND TSLL YNEY IVYD IAQV NLKY LLKL KFNF KTSL W
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP; PARP1
Positive Sample:HeLa,293F,Mouse placenta
Conjugate:Unconjugated
Cellular Localization:Nucleus, nucleolus.
Calculated MW:113kDa
Observed MW:116kDa

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Purification Method:Affinity purification
Gene ID:142
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using PARP1 Rabbit pAb (CAB0010) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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