The PE-Cyanine5 Anti-Mouse Ly6A/E (Sca-1) Antibody (D7) (AGEL2348) is a powerful tool for researchers studying stem cell biology and immunology. This antibody is specially designed to target Ly6A/E, also known as Sca-1, a cell surface marker associated with stem cells and immune cell populations in mice.Derived from monoclonal sources, this antibody exhibits high specificity and sensitivity in binding to Ly6A/E, enabling precise detection and analysis of target cells in various research applications such as flow cytometry, immunofluorescence, and immunohistochemistry. Its conjugation with PE-Cyanine5 allows for robust signal detection with minimal background noise, ensuring reliable and reproducible results.Ly6A/E (Sca-1) is a key marker for identifying and characterizing stem cells, particularly in the hematopoietic system, where its expression is associated with progenitor cells and multipotent stem cells.
By facilitating the identification and isolation of these cell populations, the PE-Cyanine5 Anti-Mouse Ly6A/E (Sca-1) Antibody (D7) (AGEL2348) is invaluable for investigating stem cell dynamics, immune responses, and developmental processes in experimental models.Enhance your research capabilities with this high-quality antibody designed to accelerate your discoveries in stem cell biology, immunology, and related fields. Uncover the complex mechanisms governing stem cell regulation and immune function with the precision and reliability offered by the PE-Cyanine5 Anti-Mouse Ly6A/E (Sca-1) Antibody (D7) (AGEL2348).
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P05533
Gene ID:
110454
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
Ly-6A/E, also known as Sca-1, is an 18 kD member of the Ly-6 multigene family. Ly6A/E is a glycosylphosphatidylinositol (GPI)-linked protein expressed on hematopoietic stem cells. In mice expressing the Ly-6.2 haplotype (e.g., AKR, C57BL, C57BR, DBA/2, SJL, SWR, and 129), Ly-6A/E is also expressed on peripheral B lymphocytes and thymic and peripheral T lymphocytes. Strains expressing the Ly-6.1 haplotype (e.g., BALB/c, CBA, C3H/He, DBA/1, and NZB) have low Ly-6A/E expression on resting peripheral lymphocytes. The expression of Ly-6A/E on lymphocytes is upregulated upon activation from both Ly6.1 and Ly6.2 haplotype mice. Ly-6A/E is thought to be involved in the regulation of both T and B cell responses.
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