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    Serum vs Plasma: Key Differences & When to Use Each [Guide](Post)

    Sample Preparation · ImmunoassaySerum vs Plasma: Key Differences and When to Use EachSerum and plasma come from the same blood draw but are not interchangeable. One is collected after clotting, the o ...

    What are the stages of Parkinson's disease?(Post)

    What is Parkinson’s disease? Parkinson's disease can be seen as a neurodegenerative disease because it is associated with the loss of nerve ce ...

    IgA Test – Normal Ranges, Results & What They Mean(Post)

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    Mononuclear Phagocytes in Health and Disease(Post)

    Mononuclear phagocytes, essential in immunity and homeostasis, perform diverse roles from phagocytosis to tissue repair, influencing health and disease. Key Takeaways: Mononuclear ...

    MAPK Signaling: Unraveling the Pathway of Mitogen Stimulation(Post)

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    What is CAR T-cell therapy?(Post)

    CAR T-cell therapy CAR (Chimeric Antigen Receptor) T-cell Therapy is a type of cancer treatment. CAR T-cells are made in the laboratory and they have an artificially created receptor on th ...

    Immuno-Biomaterial Development | Assay Genie(Post)

    Background I am a 3rd year PhD student in Trinity College Dublin and my project is very much an interdisciplinary one. I’m very lucky to get to work between two great labs, Dr. Aisling Dun ...

    Leukocytes : Basics to Diseases(Post)

    Only 1% of our blood is made up of white blood cells, but they have a significant impact. Alternatively referred to as leukocytes, white blood cells. We are shielded from disease an ...

    Protease vs Peptidase: Understanding Enzymatic Digestion(Post)

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    Gut Inflammation and Inflammatory Diseases (Post)

    What is Gut Inflammation? The gut, or gastrointestinal (GI) tract is a long tube that starts from the mouth and extends to the anus. It includes various organs suc ...

    mRNA-1010 and Beyond: How Moderna's mRNA Platform is Revolutionizing Hantavirus Vaccine Development(Post)

    Hantavirus, a silent threat lurking in rodent populations, has long posed a significant public health challenge with its severe and often fatal outcomes. For decades, the quest for effective vaccine ...

    Cortisol and the Immune Response(Post)

    Endocrinology · ImmunologyCortisol and the Immune ResponseCortisol is the body’s primary stress hormone — a glucocorticoid released by the adrenal gland that powerfully shapes the immune system. Acti ...

    ​TNF alpha & Inflammation(Post)

    Immunology · Cytokine SignallingTNF-alpha and Inflammation: Structure, Signalling & TherapyTumour necrosis factor alpha (TNF-α) is one of the most important pro-inflammatory cytokines in the body ...

    microbiota & immune system signaling | Assay Genie(Post)

    You are only part human. In some ways, you are as much bacteria as you are mammal, and in some ways bacteria make up far more of you than your own familiar cells and genes! It is becoming ...

    Leukemia Inhibitory Factor (LIF)(Post)

    Leukemia Inhibitory Factor (LIF) is a cytokine that plays a crucial role in various physiological processes within the human body. It has gained significant attention in the field o ...

    Alternative Complement Pathway: Activation, Regulation, and Significance(Post)

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    Personalized Vaccines in Cancer Treatment: The Future of Immunotherapy(Post)

    What Are Personalized Cancer Vaccines? Personalized cancer vaccines are a cutting-edge approach in cancer treatment that are designed to activate a patient's immune s ...

    How we can target the underlying immune processes in pathological inflammation in obesity, cancer and liver disease.(Post)

    Dr. Melissa Conroy, TTMI I am an immunologist and senior research fellow in the Cancer Immunology and Immunotherapy Group, Department of Surgery at Trinit ...

    Understanding Platelet Activation: A Comprehensive Overview(Post)

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    Pyruvate dehydrogenase (PDH)(Post)

    Pyruvate dehydrogenase is a complex enzyme involved in the conversion of pyruvate, a product of glycolysis, into acetyl-CoA, a crucial molecule in energy production and intermediary ...

    Blood Coagulation Signaling Pathways: A Critical Overview(Post)

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    5 Types of Immunoglobulins: IgG, IgA, IgM, IgD & IgE(Post)

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    What is RNAi? All You Need to Know(Post)

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    Schwann Cells: Specialized Cells that Support Nerve Function(Post)

    Schwann cells are cells that play a vital role in nerve function. They are responsible for myelinating axons and helping to ensure the transmission of electrical signals between neurons. Schwann ...

    A Quick Guide to Myelin(Post)

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    Autophagy in Focus: Molecular Mechanisms and Functional Insights(Post)

    Autophagy, a fundamental cellular process, plays an indispensable role in maintaining cellular homeostasis and ensuring the efficient recycling of cellular components. Through this ...

    Coeliac Disease Signaling – Review | Assay Genie(Post)

    By Ciara Coleman PhD General Introduction Coeliac Disease (CD) is defined as a common, chronic inflammatory di ...

    Bone Resorption: Process, Markers & Clinical Significance(Post)

    Unravel the complexities of bone resorption, a crucial biological process essential for skeletal health and calcium regulation, through the intricate roles of osteoclasts and osteoblasts. K ...

    Sepsis and Immune Dysregulation(Post)

    Exploring sepsis: a critical imbalance in the immune response to infection. Key Takeaways: Sepsis is a severe, immune-driven response to infection causing systemic inflammation and poten ...

    Transmission of SARS-CoV-2 (COVID-19) via Droplets and Aerosols (Post)

    Transmission of SARS-CoV-2 (COVID-19) via Droplets and Aerosols What is COVID-19? COVID-19, the dise ...

    Monocytes: An Overview (Post)

    Monocytes, as part of the innate immune system, act as the first line of defense against foreign invaders. One of their primary functions is phagocytosis, a crucial process in which they engul ...

    Myeloid Lineage: Pioneers of Immune Cell Production(Post)

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    The Role of Tumor Suppressor Genes in Cancer: Knudson Hypothesis & Oncogenes(Post)

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    The Battle of Antibiotics: Penicillin vs. Streptomycin(Post)

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    The Gut Microbiome and Autoimmune Diseases: How Gut Bacteria Influence Immune Response(Post)

    What are Autoimmune Diseases? Autoimmune diseases are a diverse group of disorders where the immune system mistakenly attacks the body's own cells, tissues, and organ ...

    Hepatocyte growth factor (HGF) (Post)

    What is Hepatocyte Growth Factor? Hepatocyte growth factor (HGF) is a cytokine that is mainly produced by the liver. HGF is a pleiotrophic cytokine that regulates cell growth, motili ...

    Data Science for Immunologists | Assay Genie(Post)

    By Dr. Niclas Thomas “Data science” is a recent addition to the vocabulary of analytics, and can mean many different things to different people. As f ...

    VEGF: Inflammation and Tumourigenesis(Post)

    What is VEGF? Vascular Endothelial Growth Factors (VEGFs) are a group of homodimeric polypeptides, and are master regulators of vascular development, maintenance and ...

    Colorectal Cancer Review (CRC) - Assay Genie(Post)

    By Charlotte O’Donnell PhD Cancer Carcinogenesis is a multi-step process that develops through epigenetic changes an ...

    Multiple Sclerosis and Stem Cells(Post)

    By Sonika Singh PhD candidate, University of Nottingham A Devastating Disease Multiple Sclerosis (MS) is a chronic and inflammatory disease ba ...

    Preeclampsia & immune cell regulation | Assay Genie(Post)

    What is preeclampsia? According to the World Health Organization (WHO), one in ten pregnant women is affected by hypertensive disorders, and preeclampsia ...

    PCR Detection of COVID-19 (SARS-CoV-2)(Post)

    PCR Detection of COVID-19 (SARS-CoV-2) Contents Background Assay Information Sample Types   & ...

    CD Markers Expression on B Cells(Post)

    Exploring the realm of B cells, this piece delves into the intricacies of these white blood cells, pivotal in humoral immunity. Through the lens of CD markers and immunophenotyping, we unravel ...

    p53 Protein: Mutations, Cancer Signalling & Tumour Suppression(Post)

    p53, encoded by the TP53 gene on chromosome 17, is a fundamental protein safeguarding against tumor formation. It orchestrates cellular responses to DNA damage and stress, crucially managing cell ...

    Gram-Negative Bacteria: Examples, Infections & Resistance(Post)

    What is Gram-Negative bacteria? Gram-negative bacteria are a diverse group of microorganisms characterized by their unique cell wall structure. They stain pink or red when subject ...

    The Environmental Shift: How Climate Change and Biodiversity Loss are Driving the 2026 Hantavirus Surge(Post)

    The year 2026 has brought an unsettling spotlight onto an old adversary: Hantavirus. What began as isolated cases has rapidly escalated into a multi-country surge, leaving scientists and public heal ...

    PD-1 & PD-L1 Inhibitors(Post)

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    Innate Viral Immunity & RIG-I in COVID-19(Post)

    RIG-I: Antiviral Properties in COVID-19 (SARS-CoV-2) Infection Key Points RIG-I is a cytosolic RNA ...

    GPCRs (G Protein Coupled Receptors): A Guide(Post)

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    Cystic Fibrosis: Causes, Inheritance, Treatment and Diagnosis(Post)

    What is Cystic Fibrosis? Cystic fibrosis (CF) is a genetic disorder that impairs the body's ability to produce sweat and thick mucus. CF causes mucus to build up in ...

    CD11b: Macrophages and Microglia Marker(Post)

    The immune system plays a critical role in defending the body against pathogens and maintaining tissue homeostasis. Within the intricate network of immune cells, CD11b, also known as inte ...

    Exhibition at the University of Oxford's BioEscalator(Post)

    Showcasing Innovation Assay Genie recently took part in an engaging event at Oxford’s BioEscalator, a leading innovation hub supporting scientific progress and entrepreneurship. Th ...

    Assay Genie New Asian Distributor May 2024(Post)

    Dublin, Ireland — May 20th 2024 — Assay Genie, a leading supplier of ELISA Kits, Antibodies, Cellular Assays, and In Vivo Monoclonal Antibodies, is pleased to announce partnerships wi ...

    Neuroimmunology: The Immune System of the CNS(Post)

    What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to investigating the intricate and bidirectional interactions between the ...

    von Willebrand Factor and Cancer(Post)

    What is von Willebrand Factor? Von Willebrand Factor (VWF) is a crucial glycoprotein that plays a fundamental role in blood clotting and hemostasis. Produced by endo ...

    Oct-4 Stem Cells(Post)

    Oct-4 stem cells, also known as Octamer-binding transcription factor 4 stem cells, are a fascinating area of study in the field of stem cell research. These stem cells hold great promise due to t ...

    The Role of Zonulin In Intestinal Permeability (Post)

    Gastroenterology · Barrier BiologyZonulin and Intestinal PermeabilityZonulin is the best-characterised endogenous regulator of intestinal tight junctions — the protein that opens the gut barrier on d ...

    p38 MAPK Signaling Review(Post)

    The p38 MAPK signaling pathway is an intracellular signaling pathway that plays a crucial role in cellular responses to various stressors and inflammatory stimuli. It is a part of the larger MAPK ...

    Filarial Infections - Tropical Diseases | Assay Genie(Post)

    By Juan Quintana, PhD student, University of Edinbrugh What are Neglected Tropical Diseases (NTDs)? The World Health Orga ...

    In Vitro vs In Vivo: Complete Comparison + Selection Guide | Research Methods(Post)

    Discover the distinct roles of 'In Vivo' and 'In Vitro' in biological research, where one offers a natural context and the other precise control, both vital for scientific advancement.

    What is the difference between PBS and dPBS?(Post)

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    Everything You Need to Know About Preeclampsia: A Guide(Post)

    Preeclampsia is a serious condition that can develop during pregnancy. It is marked by high blood pressure and the presence of protein in the urine and can cause serious problems for ...

    Xeroderma pigmentosum: Causes, Inheritance, Treatment and Diagnosis(Post)

    What is Xeroderma Pigmentosum? Xeroderma pigmentosum (XP) also known De Sanctis-Cacchione syndrome is a rare genetic disorder that affects the skin, eyes and central nervous system. It is c ...

    Inflammation and the aging process(Post)

    by Ryan Wallis, PhD Aging and Disease Imagine a world where everything you do is missing just a little piece and as time goes on you start to lose sense entirely. This is the dev ...

    COVID-19 (SARS-CoV-2) Assay Tests(Post)

    Rapid Antibody & Antigen tests available from Assay Genie ...

    Blood Coagulation Pathway: Factors, Cascade & Disorders [Guide](Post)

    Blood Coagulation Pathways Blood clotting, also known as hemostasis, is a fascinating and intricate process that ensures our bodies can effectively respond to injuries and prevent excessive ...

    A Guide To Tau Proteins & Tauopathies(Post)

    Neuroscience · BiomarkersA Guide to Tau Proteins & TauopathiesTau keeps the neuronal cytoskeleton standing up. When its phosphorylation goes wrong, the same protein becomes the aggregate that def ...

    Macrophage, M1 & M2, Polarization and Function(Post)

    What is a Macrophage? Macrophages are indeed a type of phagocyte, responsible for engulfing and destroying foreign particles and cellular debris. They are larger cells with more cytoplasm a ...

    Cancer Metabolism: Tumorigenesis, Metabolic Therapy & The Warburg Effect(Post)

    Cancer Metabolism is the mechanism by which cancer cells make energy in order for them to grow and spread. Even in the presence of oxygen, cancer cells increase glucose uptake and produce lactate ...

    Granulocytes Guide(Post)

    Explore the diverse roles and functionalities of granulocytes - neutrophils, eosinophils, basophils, and mast cells - as they form a critical line of defense in the immune system, res ...

    JAK-STAT Signalling and Cytokines: The What, How, and Why(Post)

    In the intricate landscape of cellular communication, lies a sophisticated ...

    Cleaved Caspase-3 and Apoptosis(Post)

    Delve into the role of Cleaved Caspase-3 in programmed cell death and its implications in disease pathologies, unraveling its regulatory mechanisms and potential as a therapeutic target.

    Physiological and Pathological functions of IL-36(Post)

    By Charlotte O'Donnell PhD Similar to IL-33, IL-36R ligands are involved in maintaining intestinal homeostasis. Analogous to IL-33, d is local ...

    Mouse Injection Guide: Intraperitoneal, Subcutaneous, Intramuscular & Intravenous Routes(Post)

    In Vivo Methods · ProtocolsMouse Injection Guide: Intraperitoneal, Subcutaneous, Intramuscular & Intravenous RoutesRoute choice and injection technique determine how much of a dose actually reach ...

    Oligodendrocytes: Complete Guide + Functions & Development(Post)

    Oligodendrocytes are pivotal CNS cells, integral for myelin formation and nerve function, with implications in various neurological disorders. Key Takeaways Oligodendrocytes are speci ...

    Streptococcus pneumoniae: Pathogenesis, Diagnosis, and Treatment(Post)

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    IL-10 signalling and regulation(Post)

    Explore the complexities of Interleukin-10 (IL-10) signaling and regulation, a crucial aspect in immune response modulation and its dual roles in cancer development and therapy. Key Takeaways ...

    C reactive protein(Post)

    Delve into the world of C-reactive protein (CRP), a critical player in the body's response to inflammation, and understand its role in health and disease. Key Takeaways C-reacti ...

    Cyclins and Cyclin Dependent Kinase – Review(Post)

    Cyclins and CDKs are central to cell cycle control, with specific cyclin-CDK pairs regulating different phases, ensuring orderly progression and genomic integrity in cell division. Key Takeaw ...

    NK cell activation & innate cytotoxicity(Page)

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    In Vivo depletion atlas(Page)

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    Myeloid reprogramming in the tumour microenvironment(Page)

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    The NLRP3 inflammasome & pyroptosis(Page)

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    Protocols(Page)

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    CD4+ T-helper cell differentiation(Page)

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    Regulatory T-cell (Treg) suppression & the IL-2 axis(Page)

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    T-Cell Co-Stimulation & Agonist Checkpoint Pathway(Page)

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    B-cell activation and the germinal centre reaction(Page)

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    Cytokine neutralisation network(Page)

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    cGAS-STING cytosolic DNA sensing(Page)

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    Cytokine JAK/STAT signalling(Page)

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    T-cell receptor (TCR) signalling(Page)

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    TGF-β/SMAD signalling(Page)

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    CAR-T cell signalling(Page)

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    Resources(Page)

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    PD-1 PD-L1 Pathway Diagram(Page)

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    Biosimilar Antibodies(Page)

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    Mycoplasma Troubleshooting Tips & FAQ(Page)

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