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Oct-4 Stem Cells(Post)
Oct-4 stem cells, also known as Octamer-binding transcription factor 4 stem cells, are a fascinating area of study in the field of stem cell research. These stem cells hold great promise due to th
An insight into the topology of the Enteric Nervous System(Post)The Enteric Nervous system (ENS) is one of the largest subdivisions of the Peripheral Nervous System. This remarkable system is embedded between sheets of smooth muscle cells of the intestinal
Tips for writer’s block(Post)Writer’s block can be a big stumbling block when trying to write your PhD thesis, grant or a paper you are trying to get publish. During the early stages of writing my PhD thesis I suffered
How does Acute Myeloid Leukaemia start?(Post)I have been in the situation that I’m sure many of us have. I work on genes, which if you name to any right-minded individual, sound like a random string of nonsensical gibberish. So, maybe
Targeting CD200: Unlocking Immune Suppression in Tumors(Post)Immune evasion is one of the hallmarks of cancer, where tumor cells employ various strategies to suppress immune responses and prevent destruction by the body’s defense systems. CD200, a
Unveiling Prezalumab: Targeting the Role of Anti-CD47 in Cancer Immunotherapy(Post)What You Need to Know About PrezalumabWhat is Prezalumab?Prezalumab is a monoclonal antibody designed to target CD47, a protein often overexpressed in cancer cells to evade immune detect
3D Respiratory Organoids Cell Viability in a High-throughput 384-well Plate Assay(Post)The Assay Genie 3D Organoid Cell Viability Assay (AKES081) provided superior results compared to ThermoScientific PrestoBlue, maintaining over 100% viability at all time points in untrea
TGF-Beta SMAD Signalling Pathway: Function, Readouts and Assays(Post)Almost all of the TGF-β in a tissue is already there, and almost none of it is active. That single fact reorganises how the pathway should be studied. Unlike most cytokines, TGF-β is deposited into t
microbiota & immune system signaling | Assay Genie(Post)You are only part human. In some ways, you are as much bacteria as you are mammal, and in some ways bacteria make up far more of you than your own familiar cells and genes! It is becoming
The Importance of Immunohistochemistry Training in Modern Scientific Research(Post)Immunohistochemistry (IHC) stands as a critical tool in the realm of biomedical research and diagnostic practices, offering a bridge between molecular insights and the intricate visualization of t
Trained Immunity: How Your Innate Immune System Learns and Remembers(Post)For decades, immunologists believed that only adaptive immunity—the sophisticated system of T cells and B cells—could form lasting memories of past infections. The innate immune system, our body's fir
Erk Signal Transduction Explained: Step-by-Step Process & Key Concepts(Post)The ERK signal transduction pathway stands as a fundamental mechanism in cellular biology, orchestrating a wide array of physiological processes, including cell division, differentiation, and surv
PD-1 Blockade in B-Cell Lymphomas: A Comprehensive Overview(Post)Understanding PD-1 Blockade in B-Cell Lymphomas Understanding PD-1 Blockade in B-Cell Lymphomas Introduction The programmed cell death prote
HMGB1 in inflammation and cancer(Post)HMGB1 Functional Overview High mobility group box 1 ( HMGB1), a member of the high-mobility group (HMG) family, was first identified in the thymus in 1973 an
The Intricacies of IL-21 Signaling: Impact on Diverse Immune Cell Types(Post)Interleukin-21 (IL-21) stands out as a pivotal cytokine in the complex network of immune system communication. Its role in regulating various immune cell types has drawn considerable attention
Deciphering B Cell Cancers With a Rituximab Biosimilar(Post)The fight against B cell cancers, a challenging spectrum of hematologic malignancies, has entered a new era with the introduction of rituximab biosimilars. These biosimilars promise to extend the
Gemtuzumab: Advancing CD33-Targeted Therapies in AML Research(Post)Key Facts About GemtuzumabWhat is Gemtuzumab?Gemtuzumab is an antibody-drug conjugate (ADC) targeting CD33, a protein expressed on the surface of myeloid cells. It is widely recognized f
Siltuximab: Exploring IL-6 Inhibition in Castleman’s Disease and Research(Post)Quick Facts About SiltuximabWhat is Siltuximab?Siltuximab is a monoclonal antibody targeting interleukin-6 (IL-6), a cytokine involved in inflammation and immune regulation.What is the m
Preeclampsia & immune cell regulation | Assay Genie(Post)What is preeclampsia? According to the World Health Organization (WHO), one in ten pregnant women is affected by hypertensive disorders, and preeclampsia a
Chronic myelogenous leukaemia (CML) – Review(Post)Chronic myelogenous leukaemia (CML) is a myeloproliferative haematopoietic malignancy, characterised by a karyotypic abnormality present in more than 95% of cases known as the Philadelph