2772 results for 'IFN-α'

Interferons are key cytokines in the immune system, crucial for combating viral and bacterial infections, with significant roles in both innate and adaptive immunity responses. Key Takeaways ...

Quick Facts About EmapalumabWhat is Emapalumab?Emapalumab is a fully human monoclonal antibody that neutralizes interferon-gamma (IFN-γ). It is the first FDA-approved therapy for primar ...

As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis related d ...

Quick Facts About LitifilimabWhat is Litifilimab?Litifilimab is a monoclonal antibody developed by Biogen targeting BDCA2, a receptor on plasmacytoid dendritic cells (pDCs), to regulate ...

RIG-I: Antiviral Properties in COVID-19 (SARS-CoV-2) Infection Key Points RIG-I is a cytosolic RNA ...

CXCL16 CXCL16, a unique member of the CXC chemokine family, stands at the crossroads of immune modulation and vascular biology. Initially discovered as a che ...

Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

Introduction to TNFRSF9 and Its Role in Immune ActivationTNFRSF9, also known as 4-1BB or CD137, is a co-stimulatory receptor expressed on the surface of T cells, natural killer (NK) cell ...

The Spanish flu pandemic of 1918-1919 was the deadliest in history. It is estimated that up to 100 million people died from the virus, which is more than three times the number who ...

CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...

Complete T Helper Cell Guide: Th1, Th2, Th17 & Functions - Your Ultimate Resource from Assay GenieIn this guide, we will explore the differences between TH1 and TH2 cells, their cruc ...

window.SHOGUN_IMAGE_V2_ELEMENTS = window.SHOGUN_IMAGE_V2_ELEMENTS || new Array(); window.SHOGUN_IMAGE_V2_ELEMENTS.push({ uuid: 's-19118a5d-7dea-4fc9-8267-6237960845ca' }) The T ...

Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill canc ...

What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to investigating the intricate and bidirectional interactions between the ...

Introduction to TLR4 and Cancer Toll-like receptor 4 (TLR4) is a key component of the innate immune system, primarily responsible for detecting infections and initiating inflammator ...

T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to e ...

Quick Facts About AdalimumabWhat is Adalimumab?Adalimumab is a fully human monoclonal antibody designed to neutralize tumor necrosis factor-alpha (TNF-α), a key cytokine involved in inf ...

In the realm of immunology, CXCL chemokines emerge as fascinating conductors. These small proteins, marked by their CXC motif, wield considerable influence over our immune responses and a r ...

Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly i ...

Major Histocompatibility Complex (MHC) molecules are essential for immune recognition and response. They are specialized glycoproteins that present antigens to T cells, allowing the immu ...

Key Facts About EtigilimabWhat is Etigilimab?Etigilimab is an anti-TIGIT monoclonal antibody being studied for its potential role in cancer immunotherapy.What role does Etigilimab play ...

What Are GPCRs? GPCRs, or G protein-coupled receptors, are a large family of membrane proteins that play a crucial role in cell signaling. They are involved in tran ...

Introduction to SLAMF7 in Cancer Immunotherapy SLAMF7, also known as Signaling Lymphocytic Activation Molecule F7, is a surface receptor found on natural killer (NK) cells, T cells, ...

V-domain Ig suppressor of T cell activation (VISTA) is an emerging immune checkpoint receptor that plays a key role in suppressing T cell activity within the tumor microenvironment (TME) ...

Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...

What You Need to Know About IscalimabWhat is Iscalimab?Iscalimab (CFZ533) is a monoclonal antibody targeting CD40, a key protein involved in immune system regulation.What is the mechani ...

Immune evasion is one of the hallmarks of cancer, where tumor cells employ various strategies to suppress immune responses and prevent destruction by the body’s defense systems. CD200, a ...

In the intricate tapestry of the immune system, macrophages play a pivotal role, orchestrating a wide range of biological responses that protect the body against pathogens, remove cellular debris ...

The CD28 molecule plays a crucial role in amplifying T cell activation, which is critical for mounting effective immune responses against tumors. By engaging with co-stimulatory molecule ...

Introduction to IL-10R and Immune Suppression in CancerThe interleukin-10 receptor (IL-10R) is a key player in regulating immune responses, particularly in suppressing inflammation and m ...

CD8+ T cells, also known as cytotoxic T lymphocytes (CTLs), are a critical component of the immune system. They play a vital role in defending the body against viral infections, intracel ...

Interleukin 12 in COVID-19 Prophylactics Interleukin 12 is a cytokine with wide-reaching effects in the innate and adaptive immune system. O ...

What is Hepatocyte Growth Factor? Hepatocyte growth factor (HGF) is a cytokine that is mainly produced by the liver. HGF is a pleiotrophic cytokine that regulates cell growth, motili ...

1. What is a Biosimilar? A biosimilar is a biologic medical product that is highly similar to an already-approved reference biologic. While minor differences in clinically inactive ...

The complex interplay between chemokines and cytokines is fundamental to the immune system's function, orchestrating the body's response to infection, inflammation, and injury. This detailed anal ...

What You Need to Know About DupilumabWhat is Dupilumab?Dupilumab is a fully human monoclonal antibody designed to treat various chronic inflammatory diseases by inhibiting key cytokines ...

Glucocorticoid-induced tumor necrosis factor receptor (GITR) is an immune checkpoint molecule that plays a crucial role in regulating T cell activation and survival. In recent years, GIT ...

Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target f ...

The prevalence of obesity and its associated metabolic disorders has risen dramatically in recent decades, presenting a significant global health challenge. Adipose tissue, once considered mer ...

By Eoin Mac Réamoinn Toll-like receptors (TLRs) are renowned for their fundamental roles in innate sensing and initiating inflammatory responses. TLR ...

Discover the intricacies of cellular respiration, a critical process for energy production in cells, encompassing aerobic and anaerobic pathways and their molecular mechanisms Key Takeaway ...

Exploring the multifaceted role of dendritic cells in immune function and disease. Key Takeaways DCs are professional antigen-presenting cells that capture, process, and pres ...

In the intricate landscape of the brain, cells constantly communicate, sending and receiving messages that govern our thoughts, memories, and movements. For decades, scientists believed this communic ...

Introduction to FoxP3 and Regulatory T Cells in CancerFoxP3 (forkhead box P3) is a transcription factor critical for the development and function of regulatory T cells (Tregs), a special ...

Cancer immunotherapy has revolutionized treatment options, offering strategies to harness the immune system to target and destroy tumors. One emerging area of interest is the use of OX40 ...

The immune system is the body’s main defence against infection. In order to function properly, the immune system must be able to detect and protect against infinite agents s ...

Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic re ...

What are Stem Cells? Stem cells are primitive, undifferentiated, and unspecialised cells that are found in multicellular organism ...

IntroductionCancer cells have developed sophisticated mechanisms to evade the immune system, particularly through the inhibition of T-cell responses. One such mechanism involves the prog ...

Quick Facts About PlonmarlimabWhat is Plonmarlimab?Plonmarlimab is a monoclonal antibody targeting GM-CSF, a cytokine involved in inflammation and immune responses.How does Plonmarlimab ...

Introduction to PD-1, PD-L1, and PD-L2 in Cancer ImmunotherapyThe PD-1/PD-L1 immune checkpoint pathway has been instrumental in cancer immunotherapy, with PD-1 (programmed death-1) inhib ...

Introduction to BTLA in Immune Regulation B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that plays a critical role in regulating immune responses by suppress ...

Explore the intricate world of Insulin Signaling and Receptor Tyrosine Kinases (RTKs), pivotal in regulating metabolism and influencing diseases like cancer and atherosclerosis. Key Take ...

Fenofibrate, also known as FEN, is a drug that is used to lower cholesterol levels. It works by blocking the absorption of dietary cholesterol in the small intestine and therefore, re ...

What are Natural Killer Cells? Natural Killer (NK) cells are a vital subset of lymphocytes, belonging to the same family as B cells and T cells, collectively known a ...

Imagine engineering a patient's own immune cells into precision-guided missiles against cancer—cells that can seek out and destroy tumors with remarkable specificity. This is the promise of CAR-T cel ...

Ovarian cancer is a set of malignancies that start in the ovaries, as well as adjacent portions of the fallopian tubes and peritoneum. Women have two ovaries, one on each side of the ...

Interleukin signaling is involved in a number of biological processes, including cell growth and differentiation, inflammation and immunity. Interleukins are glycoproteins which act on hem ...

Toll-Like Receptors The innate immune response has come under the spotlight in recent years due to its central role in propagating the pathoge ...

T Cell Types, Activation, Polarization & Function A comprehensive guide to T cells! window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); wi ...

Adhesion Molecules Direct cell-cell interactions are maintained and regulated by cell adhesion molecules. The expression of adhesion molecule ...

Immune Regulation in COVID-19: Immunomodulatory Mechanisms against SARS-CoV-2 Infection What is COVID-19? ...

Introduction Cellular senescence is a fascinating phenomenon that plays a crucial role in the aging process and various age-related diseases. It is essential to explore the cellular ...

Explore the complexities of Interleukin-10 (IL-10) signaling and regulation, a crucial aspect in immune response modulation and its dual roles in cancer development and therapy. Key Takeaways ...

SARS-CoV-2 Background COVID-19 is characterised by a series of biological markers. In some instances, these biomarkers can be used as potent ...

Bone Morphogenetic Proteins (BMP) were first discovered in the 1960s by Dr.Marshall Urist, an orthopaedic surgeon at UCLA (Urist 1965). BMPs are classically associated with their roles in limb ...

Innate Lymphoid Cells (ILCs) represent a fascinating component of the immune system, playing a crucial role in maintaining tissue homeostasis and mounting rapid responses against pathogens. Th ...

Th17 cells, a subset of T helper cells characterized by their production of interleukin-17 (IL-17), play a significant role in the immune system's response to pathogens and in the pathology of a ...

Immunoglobulin antibodies stand at the forefront of the immune defense system, offering a sophisticated mechanism for recognizing and neutralizing a vast array of pathogens, including bacteria, ...

Leukemia Inhibitory Factor (LIF) is a cytokine that plays a crucial role in various physiological processes within the human body. It has gained significant attention in the field o ...

Ahmad Gazali PhD candidate, University of Eastern Finland Type 1 diabetes (T1D) is an autoimmune disease where the pancreatic β cells that produce insulin, a key hormone involve ...

By Charlotte O'Donnell PhD A role for IL-33 in Barrier Function and Epithelial Wound Healing ...

Discover the critical role of cytokines as signaling molecules in immune responses, their functions, and the impact of their dysregulation, including cytokine storms. Key Takeaways: C ...

Ionotropic glutamate receptors (iGluRs) are pivotal in the fast excitatory synaptic transmission in the mammalian central nervous system (CNS). These receptors are not only crucial for normal bra ...

Antigen's are foreign molecules recognised by the immune system. Antigens can be protein, carbohydrate, lipid or nucleic acid molecules. Examples include viruses and bacteria as well as f ...

The flu is a highly contagious virus that affects the respiratory system. It can cause fever, muscle aches, and coughing. In some cases, it can lead to more serious health complicat ...

Growth factors play a vital role in the complex web of biological processes, serving as key regulators in various essential events. They exert significant influence over cruc ...

Quick Facts About AnifrolumabWhat is Anifrolumab?Anifrolumab is a monoclonal antibody that targets the type I interferon receptor, playing a crucial role in treating systemic lupus eryt ...

Exploring the Role of TIM-3/Gal-9 in Antiparasitic ImmunityIntroductionThe immune system is a complex network of cells and molecules that work together to defend the body against pathogens, including ...

Hydroxychloroquine: Potential Treatment for COVID-19 What is Hydroxychloroquine? Hydroxychloroquine (HC ...

Parkinson's disease (PD) is a progressive neurological disorder that primarily affects the motor system, leading to a wide array of symptoms ranging from tremors and stiffness to bradykinesia (sl ...

BRIEF HISTORY OF THE “GREEN” EVOLUTION OF OXYGEN AND CARBON DIOXIDE WITHIN OUR ATMOSPHERE Million years ago carbon dioxide (CO2) levels used to be consid ...

What is VEGF? Vascular Endothelial Growth Factors (VEGFs) are a group of homodimeric polypeptides, and are master regulators of vascular development, maintenance and ...

PD-L1 in Cancer Immunotherapy: Insights from Recent ResearchRecent advancements in cancer immunotherapy have underscored the critical role of programmed death-ligand 1 (PD-L1) in mediating immune eva ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-d7cc806f-05 ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-90226c4c-bea6-4a56-aae4-cf0d333ef9cf' }) A ...

ELISpot 400x more sensitive than ELISA! Detection & Visualisation at the Single-Cell Level Explore ELISpot ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-08000e48-13 ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-2dc821cd-c5c ...

Create your own custom multiplex assay with over 400 analytes to choose from! At Assay Genie we can develop custom assays to meet your research needs within 10 days! To find out more infor ...

Animal DIY ELISA Kits Maximise your research budget! Animal DIY (Do-It-Yourself) ELISA kits are sets of reagents to develop your very own san ...

Multiplex Assays "It’s like doing 24 different ELISA in every well!" GeniePlex Multiplex Assays allow researchers to quantify up to 24 analytes in as little as 15μL of sample ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-15cace94-25b ...

High Sensitivity Cytokine ELISA Cytokine ELISA Kits & Multiplex ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push( ...

ELISA Sampler Packs Based on thousands of citations and years of scientific endeavour, Assay Genie has developed ELISA Sampler Packs. An ELISA Sampler Pack is a ...

{ "@context" : "http://schema.org", "@type" : "Article", "name" : "PharmaGenie ELISA キット", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "dat ...

{ "@context" : "http://schema.org", "@type" : "Article", "name" : "IL-6 개요", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublished" : ...

window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-6747133c-26 ...