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Anti-STX1A Antibody (CAB19243)

SKU:
CAB19243
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
STX1A
HPC-1
P35-1
STX1
SYN1A
syntaxin-1A
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:STX1A Rabbit mAb
Product Code:CAB19243
Size:20uL, 50uL, 100uL
Synonyms:STX1A, HPC-1, P35-1, STX1, SYN1A, syntaxin-1A
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human STX1A.
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:C6, U-87MG, Rat brain
Immunogen:Recombinant protein of human STX1A.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6804
Uniprot:Q16623
Cellular Location:Cell junction, Cell membrane, Cytoplasmic vesicle, Secreted, Single-pass type IV membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome
Calculated MW:33kDa
Observed MW:33KDa
UniProt Protein Function:STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Cellular Component: actomyosin; cell junction; cytoplasmic vesicle; endomembrane system; integral to membrane; intracellular organelle; membrane; neuron projection; plasma membrane; protein complex; secretory granule; SNARE complex; synapse; synaptic vesicle; synaptic vesicle membrane; voltage-gated potassium channel complex

Molecular Function:ATP-dependent protein binding; calcium channel inhibitor activity; calcium-dependent protein binding; chloride channel inhibitor activity; glycoprotein binding; kinase binding; myosin binding; myosin head/neck binding; protein binding; protein binding, bridging; protein domain specific binding; protein heterodimerization activity; protein N-terminus binding; SNAP receptor activity; SNARE binding

Biological Process: calcium ion-dependent exocytosis; exocytosis; intracellular protein transport; neurotransmitter transport; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; positive regulation of exocytosis; positive regulation of neurotransmitter secretion; regulation of exocytosis; response to gravity; secretion by cell; synaptic vesicle fusion to presynaptic membrane; transport; vesicle docking; vesicle-mediated transport

NCBI Summary:This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:Q16623
NCBI GenInfo Identifier:2501084
NCBI Gene ID:6804
NCBI Accession:Q16623.1
UniProt Secondary Accession:Q16623,O35526, P32851,
UniProt Related Accession:Q16623
Molecular Weight:33,054 Da
NCBI Full Name:Syntaxin-1A
NCBI Synonym Full Names:syntaxin 1A
NCBI Official Symbol:STX1A  
NCBI Official Synonym Symbols:STX1; HPC-1; P35-1; SYN1A  
NCBI Protein Information:syntaxin-1A
UniProt Protein Name:Syntaxin-1A
UniProt Synonym Protein Names:Neuron-specific antigen HPC-1
Protein Family:Syntaxin
UniProt Gene Name:Stx1a  
UniProt Entry Name:STX1A_MOUSE

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