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Anti-UQCRC2 Antibody (CAB4181)

SKU:
CAB4181
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 9 Anti-UQCRC2 Antibody CAB4181
  • Cell Biology Antibodies 9 Anti-UQCRC2 Antibody CAB4181
  • Cell Biology Antibodies 9 Anti-UQCRC2 Antibody CAB4181
  • Cell Biology Antibodies 9 Anti-UQCRC2 Antibody CAB4181
€139 - €419
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Description

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Antibody Name:Anti-UQCRC2 Antibody
Antibody SKU:CAB4181
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 224-453 of human UQCRC2 (NP_003357.2).
Application:WB IHC IP
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, MCF7, HepG2, H460, Mouse kidney, Mouse brain, Mouse liver, Rat spinal cord, Rat testis, NCI-H460
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 224-453 of human UQCRC2 (NP_003357.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GVSH PVLK QVAE QFLN MRGG LGLS GAKA NYRG GEIR EQNG DSLV HAAF VAES AVAG SAEA NAFS VLQH VLGA GPHV KRGS NTTS HLHQ AVAK ATQQ PFDV SAFN ASYS DSGL FGIY TISQ ATAA GDVI KAAY NQVK TIAQ GNLS NTDV QAAK NKLK AGYL MSVE SSEC FLEE VGSQ ALVA GSYM PPST VLQQ IDSV ANAD IINA AKKF VSGQ KSMA ASGN LGHT PFVD EL
Gene ID:7385
Uniprot:P22695
Cellular Location:Matrix side, Mitochondrion inner membrane, Peripheral membrane protein
Calculated MW:48kDa
Observed MW:48kDa
Synonyms:UQCRC2, MC3DN5, QCR2, UQCR2
Background:The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5.
UniProt Protein Function:UQCRC2: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
UniProt Protein Details:

Protein type:EC 1.10.2.2; Mitochondrial; Oxidoreductase; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 16p12

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial respiratory chain complex III

Molecular Function:protein binding; metal ion binding; metalloendopeptidase activity; protein complex binding

Biological Process: cellular metabolic process; aerobic respiration; proteolysis; oxidative phosphorylation

Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 5

NCBI Summary:The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
UniProt Code:P22695
NCBI GenInfo Identifier:21903482
NCBI Gene ID:7385
NCBI Accession:P22695.3
UniProt Secondary Accession:P22695,Q9DB77, P32551,
UniProt Related Accession:P22695
Molecular Weight:48kDa
NCBI Full Name:Cytochrome b-c1 complex subunit 2, mitochondrial
NCBI Synonym Full Names:ubiquinol-cytochrome c reductase core protein 2
NCBI Official Symbol:UQCRC2  
NCBI Official Synonym Symbols:QCR2; UQCR2; MC3DN5  
NCBI Protein Information:cytochrome b-c1 complex subunit 2, mitochondrial
UniProt Protein Name:Cytochrome b-c1 complex subunit 2, mitochondrial
UniProt Synonym Protein Names:Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2
UniProt Gene Name:UQCRC2  
UniProt Entry Name:QCR2_HUMAN
Anti-UQCRC2 Antibody (CAB4181)Western blot analysis of extracts of various cell lines, using UQCRC2 antibody (CAB4181) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-UQCRC2 Antibody (CAB4181)Immunohistochemistry of paraffin-embedded human colon using UQCRC2 Rabbit pAb (CAB4181) at dilution of 1:100 (40x lens).
Anti-UQCRC2 Antibody (CAB4181)Immunohistochemistry of paraffin-embedded rat kidney using UQCRC2 Rabbit pAb (CAB4181) at dilution of 1:100 (40x lens).
Anti-UQCRC2 Antibody (CAB4181)Immunoprecipitation analysis of 200ug extracts of HepG2 cells using 1ug UQCRC2 antibody (CAB4181). Western blot was performed from the immunoprecipitate using UQCRC2 antibody (CAB4181) at a dilition of 1:1000.

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