Description
c-Jun (Phospho-Thr91)Transcription Factor Activity Assay
The c-Jun Phospho Thr91 Transcription Factor Activity Assay is a highly sensitive and specific kit designed to detect the activity of the c-Jun transcription factor in cellular samples. This assay is ideal for researchers studying cell signaling pathways, gene regulation, and cancer biology.The c-Jun transcription factor plays a critical role in cell growth, differentiation, and apoptosis, making it a key player in various cellular processes. The phosphorylation of c-Jun at Thr91 is known to regulate its activity, and aberrant activation of c-Jun has been linked to diseases such as cancer and inflammatory disorders.
With the c-Jun Phospho Thr91 Transcription Factor Activity Assay, researchers can accurately measure the activity of c-Jun in their samples, allowing for a better understanding of its role in disease development and progression. This kit provides reliable and reproducible results, making it a valuable tool for advancing research in the field of molecular biology and therapeutics.
| Product Name: | c-Jun (Phospho-Thr91)Transcription Factor Activity Assay |
| Product Code: | TFAB00008 |
| Target: | c-Jun (Phospho-Thr91) |
| Synonyms: | Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39 |
| Reactivity: | Human, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie c-Jun (Phospho-Thr91) transcription factor activity assay allows for the detection and qualitative analysis of c-Jun (Phospho-Thr91) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
| NCBI Summary: | This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05412 |
| NCBI GenInfo Identifier: | 135298 |
| NCBI Gene ID: | 3725 |
| NCBI Accession: | P05412.2 |
| UniProt Secondary Accession: | P05412,Q6FHM7, Q96G93, |
| UniProt Related Accession: | P05412 |
| Molecular Weight: | |
| NCBI Full Name: | Transcription factor AP-1 |
| NCBI Synonym Full Names: | jun proto-oncogene |
| NCBI Official Symbol: | JUN |
| NCBI Official Synonym Symbols: | AP1; AP-1; c-Jun |
| NCBI Protein Information: | transcription factor AP-1 |
| UniProt Protein Name: | Transcription factor AP-1 |
| UniProt Synonym Protein Names: | Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 |
| Protein Family: | C-Jun-amino-terminal kinase-interacting protein |
| UniProt Gene Name: | JUN |
| UniProt Entry Name: | JUN_HUMAN |
