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Anti-PD-1 Antibody (CAB11973)

SKU:
CAB11973
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-PD-1 Antibody CAB11973
  • Immunology Antibodies 1 Anti-PD-1 Antibody CAB11973
  • Immunology Antibodies 1 Anti-PD-1 Antibody CAB11973
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-PD-1 Antibody
Antibody SKU:CAB11973
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PD-1 (NP_005009.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, Mouse spleen, Mouse thymus, Rat thymus
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PD-1 (NP_005009.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQIP QAPW PVVW AVLQ LGWR PGWF LDSP DRPW NPPT FSPA LLVV TEGD NATF TCSF SNTS ESFV LNWY RMSP SNQT DKLA AFPE DRSQ PGQD CRFR VTQL
Gene ID:5133
Uniprot:Q15116
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:31kDa
Observed MW:40-70kDa
Synonyms:PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Background:This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
UniProt Protein Function:Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.
NCBI Summary:This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
UniProt Code:Q15116
NCBI GenInfo Identifier:145559515
NCBI Gene ID:5133
NCBI Accession:Q15116.3
UniProt Secondary Accession:Q15116,Q02242,
UniProt Related Accession:Q15116
Molecular Weight:
NCBI Full Name:Programmed cell death protein 1
NCBI Synonym Full Names:programmed cell death 1
NCBI Official Symbol:PDCD1  
NCBI Official Synonym Symbols:PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1  
NCBI Protein Information:programmed cell death protein 1
UniProt Protein Name:Programmed cell death protein 1
UniProt Synonym Protein Names:CD_antigen: CD279
UniProt Gene Name:PDCD1  
Anti-PD-1 Antibody (CAB11973)Western blot analysis of extracts of various cell lines, using PD-1 antibody (CAB11973) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min.
Anti-PD-1 Antibody (CAB11973)Immunohistochemistry of paraffin-embedded human spleen using PD-1 Rabbit pAb (CAB11973) at dilution of 1:100 (40x lens).
Anti-PD-1 Antibody (CAB11973)Immunofluorescence analysis of U2OS cells using PD-1 antibody (CAB11973) at dilution of 1:100. Blue: DAPI for nuclear staining.

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