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10351 results for 'Apolipoprotein C-II/ApoC2'

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    Diabetic Retinopathy: premature cellular senescence and microvascular dysfunction(Post)

    By Pietro Maria Bertelli, PhD Candidate, Queens University Belfast Introduction Eye complications are very frequent in patients with diabetes, a ...

    Cell Synchronisation Methods(Post)

    What is Cell Synchronisation? Cell synchronisation is a process by which cells at different stages of the cell cycle in a culture are brought to the same phase. Cell synchronisation is ...

    Unraveling the Mysteries of Platelet-Activating GPCR Signaling(Post)

    Platelet activation plays a pivotal role in hemostasis, the process that stops bleeding and initiates wound healing. Central to this process is the activation of G protein-coupled receptors (GPCR ...

    CD4+ T Cells: Unveiling the Role of Helper and Regulatory T Cells(Post)

    CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...

    Types of PCR – 7 Methods, Principles & Applications(Post)

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    Non-Small Cell Lung Carcinoma: Understanding, Diagnosing, and Treating NSCLC(Post)

    Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer, representing about 85% of all lung cancer cases. NSCLC includes several subtypes, with distinct biological c ...

    LILT: A Novel Immune Checkpoint for Cancer Therapy(Post)

    Recent advances in immunotherapy have highlighted the importance of targeting immune checkpoints to enhance the immune system’s ability to combat cancer. A new potential target in this g ...

    Understanding T Cell Fatigue: Implications for Immune Function and Therapeutic Interventions(Post)

    T cells are central players in adaptive immunity, responsible for recognizing and eliminating infected or aberrant cells. Upon encountering antigens, T cells undergo clonal expansion and diffe ...

    Alzheimer's Disease: A Comprehensive Insight(Post)

    Alzheimer's disease stands as a formidable challenge in the realm of neurological disorders, characterized by its progressive nature and profound impact on cognitive functions. This article delv ...

    ST2 and IL33(Post)

    ST2, a member of the IL-1R Subfamily ST2 is a member of the IL-1R subfamily and was identified in 1989 [1]. The ST2 gene is located on chromos ...

    CXC Chemokine Family(Post)

    In the realm of immunology, CXCL chemokines emerge as fascinating conductors. These small proteins, marked by their CXC motif, wield considerable influence over our immune responses and a r ...

    The role of IL-18 in health and disease(Post)

    Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...

    How to Choose a Secondary Antibody(Post)

    The selection of a secondary antibody is a critical step in the experimental design of various immunodetection methods, including Western Blot, ELISA, immunohistochemistry (IHC), and immunofluore ...

    Western Blot Training: A Comprehensive Guide(Post)

    Western blotting, a cornerstone technique in molecular biology, biochemistry, and immunogenetics, is pivotal for detecting specific proteins in a sample. Its applications span various scientific ...

    HMGB1 in inflammation and cancer(Post)

    HMGB1 Functional Overview High mobility group box 1 ( HMGB1), a member of the high-mobility group (HMG) family, was first identified in the thymus in 1973 a ...

    Milatuzumab: Unveiling Its Role in Cancer Immunotherapy and Research(Post)

    What You Need to Know About MilatuzumabWhat is Milatuzumab?Milatuzumab is a humanized monoclonal antibody targeting CD74, a molecule involved in antigen presentation and cell signaling.

    Understanding activating PIK3CA mutations in human disease(Post)

    Ralitsa R. Madsen – University of Cambridge Metabolic Research Laboratories Each one of us is the result of an extraordinary developmental proce ...

    Flow Cytometry Protocol | 10 Hints & Tips(Post)

    Flow Cytometry Protocol The meaning is in the name: Flow = in motion, Cyto = cells, Metry = measure. What is Flow Cytometry? Flow c ...

    Pancreatic Cancer and its Poor Prognosis(Post)

    Myrna Hurtado, PhD Student, University of North Texas Health Science Center Advancements in modern medicine have resulted in significantly prolonging and ...

    p53 Protein: Mutations, Cancer Signalling & Tumour Suppression(Post)

    Cancer Biology · Cell Signallingp53: Structure, Signalling, Regulation and Mutation in Cancerp53 is the most frequently mutated gene in human cancer, and the reason is structural: a single tetrameric ...

    اختبار COVID-19 Rapid POC(Post)

    اختبار COVID-19 POC السريع الوصف إن مجموعة الفحص الجيني تستخدم فقط COVID-19 Rapid POC ( ...

    COVID-19（SARS-CoV-2）トリプレックスRT-qPCR検出キット| Assay Genie(Post)

    COVID-19（SARS-CoV-2）トリプレックスRT-qPCR検出キット COVID-19アッセイの概要： この製品は、新規コロナウイルスSARS-CoV-2によって引 ...

    CRISPR-Powered Light Sensors: A New Frontier in Ultra-Sensitive Cancer Detection(Post)

    Cancer detection often relies on advanced imaging or invasive procedures, frequently catching the disease at later, more challenging stages. Imagine a future where a simple, non-invasive test could ...

    Preeclampsia & immune cell regulation | Assay Genie(Post)

    What is preeclampsia? According to the World Health Organization (WHO), one in ten pregnant women is affected by hypertensive disorders, and preeclampsia ...

    Epigenetic modifiication & Histone methylation(Post)

    Agata Miezaniec PhD Candidate, University of Nottingham, UK Epigenetics and the link to DNA Methylation The term ‘Epigene ...

    Innate Lymphoid Cells Differentiation: Guardians of Immune Homeostasis(Post)

    Innate Lymphoid Cells (ILCs) represent a fascinating component of the immune system, playing a crucial role in maintaining tissue homeostasis and mounting rapid responses against pathogens. Th ...

    IQGAP1 signaling review(Post)

    IQGAP1: IQ-motif containing GTPase-activating-like protein-1 reviewIQ motif-containing GTPase-activating-like protein-1 (IQGAP1) is a 190 KDa protein that belongs to a conserved family of s ...

    Biomarker Testing: Advancements, Applications, and Future Directions(Post)

    Biomarkers, measurable indicators of biological processes or responses to therapeutic interventions, play a pivotal role in modern healthcare. They provide clinicians with valuable information ...

    TLX as a Novel Therapeutic Target(Post)

    Danka Kozareva PhD Candidate, University College Cork The generation of neurons from stem cells The process of generating ...

    Polo-like kinase (Plk1) substrates and mitosis(Post)

    Polo-like kinase (Plk1) Polo-like kinase (Plk1), is a serine/threonine kinase that is active during mitosis (Hamanaka et al., 1995). Its name is derived from its orig ...

    Ferroptosis: A New Frontier in Cancer Therapy(Post)

    For decades, the primary strategy in cancer treatment has been to trigger apoptosis, a form of programmed cell death, in malignant cells. However, many cancers develop resistance to apoptosis-induci ...

    MAPK Signaling: Unraveling the Pathway of Mitogen Stimulation(Post)

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    Decoding Parkinson's Disease: Insights into a Complex Neurological Disorder(Post)

    Parkinson's disease (PD) is a progressive neurological disorder that primarily affects the motor system, leading to a wide array of symptoms ranging from tremors and stiffness to bradykinesia (sl ...

    Tumor-Associated Macrophages: Double Agents in the Cancer Battlefield(Post)

    Tumor-Associated Macrophages: Double Agents in the Cancer Battlefield In the intricate theater of the human body, the immune system acts as a vigilant guardian, dispatching cellular soldiers to seek ...

    Understanding the Autophagy Pathway: A Critical Process in Cellular Maintenance(Post)

    Autophagy, a fundamental cellular process, is crucial for maintaining cellular homeostasis and responding to various stressors. This self-eating mechanism involves the degradation and recycling o ...

    Chronic myelogenous leukaemia (CML) – Review(Post)

    Chronic myelogenous leukaemia (CML) is a myeloproliferative haematopoietic malignancy, characterised by a karyotypic abnormality present in more than 95% of cases known as the Philadelp ...

    p38 MAPK Signaling Review(Post)

    The p38 MAPK signaling pathway is an intracellular signaling pathway that plays a crucial role in cellular responses to various stressors and inflammatory stimuli. It is a part of the larger MAPK ...

    LATS1/2 Kinases Review(Post)

    LATS kinases belong to a family of proteins that, in mammals, are comprised of two isoforms, LATS1 and LATS2. Originally identified in Drosophila melanogaster as Warts kinase, LATS1 and LATS2 s ...

    Apoptosis Caspase Pathways: A Closer Look at Cellular Suicide(Post)

    Apoptosis, or programmed cell death, is a fundamental process that plays a critical role in the development and maintenance of healthy tissues. Central to this process are caspases, a family of c ...

    CD25 Marker(Post)

    CD25, a key molecule in immune regulation, is integral to the function of activated lymphocytes and regulatory T cells. It's central in mediating immune responses, with implications in autoimmune ...

    Cytokinesis review(Post)

    By John Bannon PhD Early Cytokinesis Early cytokinesis; from anaphase to midbody formation cytokinesis is the physical ...

    Mycoplasma in Cell Culture Detection Guide(Post)

    As a PhD student delving deep into the realm of cellular biology, there is one antagonist that consistently challenges my research: mycoplasma. This microscopic bacterium, with its ...

    microbiota & immune system signaling | Assay Genie(Post)

    You are only part human. In some ways, you are as much bacteria as you are mammal, and in some ways bacteria make up far more of you than your own familiar cells and genes! It is becoming ...

    Galectin Therapeutics(Post)

    Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis (IPF) is a chronic, irreversible and ultimately fatal disease characterized by pro ...

    GPCRs (G Protein Coupled Receptors): A Guide(Post)

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    Key Players in T Cell Regulation: Lag-3, Tim-3, and TIGIT(Post)

    Understanding Lag-3, Tim-3, and TIGIT: Key Players in T Cell RegulationThe immune system's ability to regulate T cell responses is crucial for maintaining homeostasis and combating diseases such as c ...

    SOCS proteins: Manipulating the immune response(Post)

    Katherine Edwards, PhD Student, Queen’s University Belfast Cytokines play a vital role in immune responses enabling cross-talk between different cell types ...

    Cyclins and Cyclin Dependent Kinase – Review(Post)

    Cyclins and CDKs are central to cell cycle control, with specific cyclin-CDK pairs regulating different phases, ensuring orderly progression and genomic integrity in cell division. Key Takeaw ...

    Ubiquitin and Its Role in Cellular Regulation: A Comprehensive Overview of Modifiers and Pathways(Post)

    Ubiquitin is a small, highly conserved protein found in eukaryotic cells that plays a crucial role in regulating various cellular processes. The process of ubiquitination involves the covalent at ...

    Cleaved Caspase-3 and Apoptosis(Post)

    Cell Death · BiomarkersCleaved Caspase-3: Activation, Function and Detection in ApoptosisCaspase-3 sits at the point where apoptotic signalling becomes irreversible. It is made as an inactive proenzy ...

    NRF2 Signaling: A Keystone in Inflammation and Disease Management(Post)

    Nuclear Factor Erythroid 2–Related Factor 2 (NRF2) orchestrates a principal defense mechanism against oxidative stress and plays a pivotal role in inflammation and disease pathogenesis. This arti ...

    Inhibiting cell division(Post)

    Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surroundin ...

    Mitotic Catastrophe Review(Post)

    Delving into the intricate world of Mitotic Catastrophe, this blog unveils its critical role in cell division and cancer therapy, offering insights into its mechanisms and potential treatments ...

    IgA Test: Normal Ranges, Results & What They Mean [2026](Post)

    The IgA test, also known as immunoglobulin A test, is a diagnostic tool used to measure the levels of IgA antibodies in the blood. Immunoglobulin A (IgA) is a type of antibody that plays a cru ...

    Sensing Danger: The Biology of TLR-Mediated Inflammation(Post)

    By Eoin Mac Réamoinn Toll-like receptors (TLRs) are renowned for their fundamental roles in innate sensing and initiating inflammatory responses. TLR ...

    JAK-STAT Signaling Pathway: A Comprehensive Exploration(Post)

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    COVID-19 Biomarkers(Post)

    SARS-CoV-2 Background COVID-19 is characterised by a series of biological markers. In some instances, these biomarkers can be used as potent ...

    Chemokines versus Cytokines: A Detailed Comparative Study(Post)

    The complex interplay between chemokines and cytokines is fundamental to the immune system's function, orchestrating the body's response to infection, inflammation, and injury. This detailed anal ...

    Biomarkers & Inflammatory markers of atherosclerosis(Post)

    As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis related d ...

    Unraveling the Complexity of the Notch Signaling Pathway: A Key Player in Development and Disease(Post)

    The Notch signaling pathway is a highly conserved cellular communication system that plays a crucial role in various biological processes, including embryonic development, tissue homeostasis, ...

    BDNF in inflammation and neuropathologies(Post)

    BDNF Overview Brain-derived neurotrophic factor (BDNF) is a central mediator of neuroplasticity, a term used to describe the ability of neuron ...

    Guide to Bacterial Transformation: The Science of Genetic Manipulation(Post)

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    Can infection cause chronic disease?(Post)

    By Anusha Senevirante, Post-Doctoral researcher, Imperial College London With non-communicable diseases (or NCDs, which include heart disease, diabetes, c ...

    Enhancing Cancer Research: Syngeneic Mouse Models and Immune Checkpoint Inhibitors(Post)

    Enhancing Cancer Research: Syngeneic Mouse Models and Immune Checkpoint Inhibitors A quick guide to Syngeneic Mouse Models Syngeneic Mouse Models Cancer research has seen rem ...

    TNF cytokines and their Receptors(Post)

    The human body is a complex and intricate system where various components work together to maintain health and combat potential threats. Among these essential players are the TNF cy ...

    Tau proteins: An Overview (Post)

    The tau protein is a hot topic in the scientific world right now. This little-known protein has been linked to Alzheimer's disease, Parkinson's disease, and other neurodegenerative dise ...

    Physiological Roles for IL-33 | Assay Genie(Post)

    By Charlotte O'Donnell PhD A role for IL-33 in Barrier Function and Epithelial Wound Healing ...

    Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer(Post)

    Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Pancreatic can ...

    Carbon Dioxide sensing in Immune Cells(Post)

    BRIEF HISTORY OF THE “GREEN” EVOLUTION OF OXYGEN AND CARBON DIOXIDE WITHIN OUR ATMOSPHERE Million years ago carbon dioxide (CO2) levels used to be consid ...

    The Double-Edged Sword: How Neutrophil Traps Can Both Help and Hinder Cancer's Spread(Post)

    The Double-Edged Sword: How Neutrophil Traps Can Both Help and Hinder Cancer's Spread In the intricate battlefield of the human body, the immune system’s foot soldiers, neutrophils, have long been r ...

    Spotlight on Mitochondria(Post)

    Throughout my graduate and postgraduate studies I have been really intrigued and fascinated by the mitochondria, the organelle that keeps all of us running everyday! The more I learn about ...

    COVID-19 Rapid POC CE-IVDテスト（25テスト）| Assay Genie(Post)

    COVID-19 Rapid POC CE-IVDテスト（25テスト） 概要説明 Getein COVID-19 Rapid POC(臨床現場即時)キットは新型コロナウィルス ...

    Obinutuzumab: Advancing Targeted Therapy in Hematologic Cancers(Post)

    Quick Facts About ObinutuzumabWhat is Obinutuzumab?Obinutuzumab is a monoclonal antibody targeting CD20, primarily used in treating B-cell malignancies such as chronic lymphocytic leuke ...

    Plasma Membrane Markers(Post)

    What is a Plasma Membrane? The plasma membrane, also known as the cell membrane, is a vital component of all cells. It is a thin, semi-permeable barrier that separat ...

    Cancer & Tumour Suppressors – Mini Review(Post)

    Cancer DevelopmentCancer is a group of diseases that involves abnormal cell growth resulting in malignant tumours/ malignant neoplasms. Cancer is a leading cause of morbidity, with 14 million n ...

    Bone Resorption Explained: Process, Markers, and Clinical Insights(Post)

    Bone Biology · BiomarkersBone Resorption: Process, Markers & Clinical SignificanceBone resorption is the process by which osteoclasts break down bone tissue and release its stored minerals into t ...

    Streptococcus pneumoniae: Pathogenesis, Diagnosis, and Treatment(Post)

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    ELISA Troubleshooting: When Standards Read Below the Blank(Post)

    Quick answer On the GDF-6 (Growth Differentiation Factor 6) ELISA Kit, a researcher saw an elevated blank (OD ≈ 0.41) with the two lowest standards reading at or below ...

    Reprogramming Regulatory T Cells: A Breakthrough in Cancer Immunotherapy(Post)

    A New Dawn in Cancer Treatment: Reprogramming the Immune System's Own Soldiers For decades, the fight against cancer has been a relentless battle of attrition, with treatments like chemotherapy and ...

    Co-Immunoprecipitation (co-IP) Protocol - Mandarin(Page)

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    Non-Human Primate Multiplex ELISA Panels(Page)

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    Western Blot Protocol & Troubleshooting Guide(Page)

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    Validated GeniePlex Panels - Customer Applications(Page)

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    Chemokines(Page)

        Chemokines   Key Research Areas       C Chemokine Ligands XCL1/Lymphot ...

    ELISpot Assay Kits(Page)

    ELISpot 400x more sensitive than ELISA! Detection & Visualisation at the Single-Cell Level Explore ELISpot ...

    TCA Cycle Assays(Page)

    TCA/Krebs Cycle Assays At Assay Genie we've developed a range of TCA assays for researchers to analyse key steps in the Krebs/TCA/Citric Acid cycle pathway. Different Products ...

    Oxidative Stress Assays(Page)

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    TA Cloning(Page)

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    Phosphorylation ELISA Kits(Page)

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    Liver & Kidney Biomarker Assays(Page)

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    샌드위치 엘리사(Page)

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    Diabetes & Obesity Assays (Page)

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    Interactive Pathway Diagrams(Page)

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    Mycoplasma Testing - Detection & Elimination(Page)

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    Transcription Factor Activity Assay Kits(Page)

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    Resources(Page)

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