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Ras signaling pathway(Post)
A wide variety of cell surface receptors activate Ras GTPase, including the tyrosine receptor linked to the epidermal growth factor receptor (EGFR) (Wells 1999). Upon receptor stimulation, son o
Adipokines and Insulin Signaling Pathways: An In-Depth Exploration(Post)The prevalence of obesity and its associated metabolic disorders has risen dramatically in recent decades, presenting a significant global health challenge. Adipose tissue, once considered mere
Understanding CD16: A Comprehensive Overview(Post)CD16, also known as FcγRIII (Fc gamma receptor III), plays a crucial role in the immune system, serving as a receptor for the Fc region of immunoglobulin G (IgG). This receptor is a key player in
BTLA: A Key Player in Immune Regulation and Cancer Therapy(Post)Introduction to BTLA in Immune Regulation B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that plays a critical role in regulating immune responses by suppressing T
Understanding CD16: A Comprehensive Overview(Post)CD16, also known as FcγRIII (Fc gamma receptor III), plays a crucial role in the immune system, serving as a receptor for the Fc region of immunoglobulin G (IgG). This receptor is a key player in
Understanding Antibody Staining for Antigen Detection in Flow Cytometry(Post)Flow cytometry stands as a pivotal technique in the realms of molecular biology and immunology, enabling the analysis of physical and chemical characteristics of cells or particles as they flow in
Th17 and IL-23: Why Blocking IL-17 Sometimes Backfires(Post)Two drugs aimed at the same axis can give opposite results in the same disease. Blocking IL-23p19 is highly effective in psoriasis and works in Crohn’s disease. Blocking IL-17A directly is highly eff
A Comprehensive Overview of Cell Death(Post)Cell death is an essential aspect of cellular biology that plays a crucial role in development, homeostasis, and disease. In this blog, we try to focus on mechanisms and various type
Metabolic Bloodhounds: Engineering Immune Cells to Track Cancer's Chemical Trail(Post)Imagine a specialized squad of immune cells, meticulously trained and equipped, not just to fight cancer, but to sniff it out by its unique metabolic scent. This isn't science fiction; it's the groun
The common characteristics of cancer | Assay Genie(Post)By Shane Houston, PhD Candidate Queen’s University Belfast Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health t
CRISPR-Powered Light Sensors: A New Frontier in Ultra-Sensitive Cancer Detection(Post)Cancer detection often relies on advanced imaging or invasive procedures, frequently catching the disease at later, more challenging stages. Imagine a future where a simple, non-invasive test could s
JAK-STAT Signalling: Cytokine Receptors, JAKs, STATs and Assays(Post)Dozens of cytokines converge on four kinases and seven transcription factors. That compression is the problem JAK–STAT has to solve, and it is why this map is drawn as receptor, kinase and STAT colum
Liposomal nanosilver encapsulation for cytotoxic assays(Post)Nanosilver is the most commercialised nanoparticle routinely used for its antibacterial purposes in food preservation, cosmetic and health products such as medical devices and wound treatmen
Leukemia Inhibitory Factor: An Overview (Post)Leukemia Inhibitory Factor and JAK-STAT Signalling Pathway Leukemia inhibitory factor (LIF) is a cytokine that belongs to the interleukin-6 (IL-6) family of cytokines. Other members of
Decoding Parkinson's Disease: Insights into a Complex Neurological Disorder(Post)Parkinson's disease (PD) is a progressive neurological disorder that primarily affects the motor system, leading to a wide array of symptoms ranging from tremors and stiffness to bradykinesia (slo
Mitochondrial Transfer: A Novel Immune Evasion Mechanism in Cancer(Post)In the intricate dance between the immune system and cancer, tumors often deploy cunning strategies to evade destruction. A groundbreaking 2025 study in Nature has unveiled a startling new tactic: can
Investigating orthohantavirus infections with proteomics(Post)Sarah Brun Bar-Yaacov PhD Candidate, University of Liverpool Orthohantaviruses are a group of segmented negative-sense RNA viruses maintained as asympto
Th17 Cell Differentiation: Insights into Immunological Dynamics(Post)Th17 cells, a subset of T helper cells characterized by their production of interleukin-17 (IL-17), play a significant role in the immune system's response to pathogens and in the pathology of au
Mitophagy: The Cell's Cleanup Crew for Healthy Living(Post)Mitophagy, a term derived from the fusion of "mitochondria" and "autophagy," represents a vital cellular process responsible for the targeted degradation and recycling of dysfunctional mitochon
3D Organoid Cell Viability Assay: Performance Assessment in Human Colon Organoids(Post)The 3D Organoid Cell Viability Assay (AKES081) demonstrated high sensitivity and low cytotoxicity, making it ideal for long incubation studies (24-48 hours) and high-throughput applicati