Description
STAT2 Transcription Factor Activity Assay
The STAT2 Transcription Factor Activity Assay Kit is a powerful tool for measuring the activity of STAT2, a key transcription factor involved in immune response and cellular signaling pathways. This kit offers exceptional sensitivity and precision, allowing for accurate quantification of STAT2 activity in cell lysates and tissue samples.STAT2 is a critical regulator of gene expression, playing a vital role in the immune system's response to viral infections and other external stimuli. Dysregulation of STAT2 activity has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By monitoring STAT2 activity, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and identify potential therapeutic targets.The STAT2 Transcription Factor Activity Assay Kit provides researchers with a reliable and convenient solution for studying STAT2 activity in a variety of experimental settings. With its user-friendly protocol and robust performance, this kit is an essential tool for advancing our understanding of signaling pathways and developing new treatments for STAT2-related disorders.
| Product Name: | STAT2 Transcription Factor Activity Assay |
| Product Code: | TFAB00184 |
| Target: | STAT2 |
| Synonyms: | p113 |
| Reactivity: | Human, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie STAT2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:DNA binding; identical protein binding; protein binding; signal transducer activity; transcription factor activity Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; JAK-STAT cascade; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction |
| NCBI Summary: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P52630 |
| NCBI GenInfo Identifier: | 1711552 |
| NCBI Gene ID: | 6773 |
| NCBI Accession: | P52630.1 |
| UniProt Secondary Accession: | P52630,Q16430, Q16431, Q9UDL4, B4DLC7, G3V2M6, |
| UniProt Related Accession: | P52630 |
| Molecular Weight: | 97,457 Da |
| NCBI Full Name: | Signal transducer and activator of transcription 2 |
| NCBI Synonym Full Names: | signal transducer and activator of transcription 2 |
| NCBI Official Symbol: | STAT2 |
| NCBI Official Synonym Symbols: | P113; IMD44; ISGF-3; STAT113 |
| NCBI Protein Information: | signal transducer and activator of transcription 2 |
| UniProt Protein Name: | Signal transducer and activator of transcription 2 |
| UniProt Synonym Protein Names: | p113 |
| Protein Family: | Signal transducer and activator of transcription |
| UniProt Gene Name: | STAT2 |
| UniProt Entry Name: | STAT2_HUMAN |
