STAT2 Transcription Factor Activity Assay
- SKU:
- TFAB00184
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- STAT2
- Reactivity:
- Human
- Rat
Description
| Product Name: | STAT2 Transcription Factor Activity Assay |
| Product Code: | TFAB00184 |
| Target: | STAT2 |
| Synonyms: | p113 |
| Reactivity: | Human, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie STAT2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:DNA binding; identical protein binding; protein binding; signal transducer activity; transcription factor activity Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; JAK-STAT cascade; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction |
| NCBI Summary: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P52630 |
| NCBI GenInfo Identifier: | 1711552 |
| NCBI Gene ID: | 6773 |
| NCBI Accession: | P52630.1 |
| UniProt Secondary Accession: | P52630,Q16430, Q16431, Q9UDL4, B4DLC7, G3V2M6, |
| UniProt Related Accession: | P52630 |
| Molecular Weight: | 97,457 Da |
| NCBI Full Name: | Signal transducer and activator of transcription 2 |
| NCBI Synonym Full Names: | signal transducer and activator of transcription 2 |
| NCBI Official Symbol: | STAT2Â Â |
| NCBI Official Synonym Symbols: | P113; IMD44; ISGF-3; STAT113Â Â |
| NCBI Protein Information: | signal transducer and activator of transcription 2 |
| UniProt Protein Name: | Signal transducer and activator of transcription 2 |
| UniProt Synonym Protein Names: | p113 |
| Protein Family: | Signal transducer and activator of transcription |
| UniProt Gene Name: | STAT2Â Â |
| UniProt Entry Name: | STAT2_HUMAN |
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