Description
c-Jun (Phospho-Ser243)Transcription Factor Activity Assay
The c-Jun Phospho-Ser243 Transcription Factor Activity Assay is a powerful tool for researchers studying the activity of the c-Jun transcription factor in cellular signaling pathways. This assay allows for the quantification of c-Jun phosphorylation at serine 243, providing valuable insights into the regulation of gene expression and cell survival.The c-Jun transcription factor is a key player in cell growth, differentiation, and apoptosis, making it a critical target for drug discovery and biomarker development. By accurately measuring c-Jun activity in cell lysates or tissue samples, researchers can better understand the molecular mechanisms underlying various diseases, including cancer, inflammation, and neurological disorders.
With its high sensitivity and specificity, the c-Jun Phospho-Ser243 Transcription Factor Activity Assay offers reliable and reproducible results, making it an essential tool for studying the role of c-Jun in cellular processes and disease progression. Whether you are investigating signaling pathways, drug efficacy, or biomarker discovery, this assay provides valuable data for advancing your research efforts.
| Product Name: | c-Jun (Phospho-Ser243)Transcription Factor Activity Assay |
| Product Code: | TFAB00006 |
| Target: | c-Jun (Phospho-Ser243) |
| Synonyms: | Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie c-Jun (Phospho-Ser243) transcription factor activity assay allows for the detection and qualitative analysis of c-Jun (Phospho-Ser243) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
| NCBI Summary: | This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05412 |
| NCBI GenInfo Identifier: | 135298 |
| NCBI Gene ID: | 3725 |
| NCBI Accession: | P05412.2 |
| UniProt Secondary Accession: | P05412,Q6FHM7, Q96G93, |
| UniProt Related Accession: | P05412 |
| Molecular Weight: | |
| NCBI Full Name: | Transcription factor AP-1 |
| NCBI Synonym Full Names: | jun proto-oncogene |
| NCBI Official Symbol: | JUN |
| NCBI Official Synonym Symbols: | AP1; AP-1; c-Jun |
| NCBI Protein Information: | transcription factor AP-1 |
| UniProt Protein Name: | Transcription factor AP-1 |
| UniProt Synonym Protein Names: | Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 |
| Protein Family: | C-Jun-amino-terminal kinase-interacting protein |
| UniProt Gene Name: | JUN |
| UniProt Entry Name: | JUN_HUMAN |
