10305 results for 'TNF- alpha'

Quick Facts About EldelumabWhat is Eldelumab?Eldelumab is a monoclonal antibody targeting TNFSF14 (LIGHT), a key regulator in immune system signaling, with potential applications in infl

Immunology · HyperinflammationCytokine Storm and Cytokine Release Syndrome: Mechanisms, Triggers and MarkersA cytokine storm is a self-amplifying inflammatory response in which cytokine release drives

The Th1 Pathway In this guide, we will explore the differences between TH1 and TH2 cells, their crucial roles in the immune system, and the contributions of cytokines and transcription f

This article breaks down the glycoprotein Granulocyte-macrophage colony-stimulating factor (GM-CSF) detailing its structure, function and therapeutic uses. It also describes its role in imm

What is Gut Inflammation? The gut, or gastrointestinal (GI) tract is a long tube that starts from the mouth and extends to the anus. It includes various organs such

Cell Biology · PathologyNecrosis: Types, Causes, Mechanisms and How It Is MeasuredNecrosis is cell death accompanied by membrane rupture and release of intracellular contents — which is what makes it

What is Parkinson’s disease? Parkinson's disease can be seen as a neurodegenerative disease because it is associated with the loss of nerve cel

What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to investigating the intricate and bidirectional interactions between the c

Fenofibrate, also known as FEN, is a drug that is used to lower cholesterol levels. It works by blocking the absorption of dietary cholesterol in the small intestine and therefore, red

Mouse Multiplex ELISA & Cytokine Assay Panels | Assay Genie

Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly in

Quick Facts About SecukinumabWhat is SecukinumabSecukinumab is a monoclonal antibody that targets interleukin-17A (IL-17A), a key cytokine involved in inflammatory and autoimmune respons

Almost any inflammatory phenotype in a mouse can be assigned to a cytokine by taking that cytokine away. Neutralisation is the most direct causal test immunology has: inject a functional-grade antibo

Toll-like receptors are the reason a milligram of endotoxin can kill a mouse. They are the fastest, least discriminating layer of immunity: germline-encoded sensors that read conserved microbial chem

NF-κB is not one pathway, it is two clocks running at different speeds. The canonical arm fires within minutes of TNF-α, IL-1β or LPS reaching the surface, peaks, and is switched off by feedback it e