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Antigen Processing and Presentation: MHC-I, MHC-II, Cross-Priming(Post)
Every T-cell response begins with a protein being taken apart. Before a CD8 or CD4 T cell can see anything, an antigen has to be degraded into peptides of the right length, delivered to the right com
Sirexatamab: Advancing CD47-Targeted Cancer Therapy and Research(Post)Quick Facts About SirexatamabWhat is Sirexatamab?Sirexatamab is an investigational monoclonal antibody designed to target CD47, a key immune checkpoint involved in cancer evasion.How Doe
Apamistamab: Advancing Leukemia Treatment through Targeted Radioimmunotherapy(Post)Quick Facts About ApamistamabWhat is Apamistamab?Apamistamab is a monoclonal antibody that targets the CD45 antigen on hematopoietic cells.How does Apamistamab work?When labeled with the
Troubleshooting high ELISA concentrations(Post)QUICK ANSWER If your ELISA returns sample concentrations that are orders of magnitude too high, the assay itself is usually fine — the error is almost always in data analysis. The most
Citrullination, NETs and Rheumatoid Arthritis(Page) What are the stages of Parkinson's disease?(Post)What is Parkinson’s disease? Parkinson's disease can be seen as a neurodegenerative disease because it is associated with the loss of nerve cel
What is CAR T-cell therapy?(Post)CAR T-cell therapy CAR (Chimeric Antigen Receptor) T-cell Therapy is a type of cancer treatment. CAR T-cells are made in the laboratory and they have an artificially created receptor on the
CXC Chemokine Family(Post)In the realm of immunology, CXCL chemokines emerge as fascinating conductors. These small proteins, marked by their CXC motif, wield considerable influence over our immune responses and a ra
Apoptosis Pathway: Death Receptor, Mitochondrial and Granzyme Routes(Post)Apoptosis is not one pathway but three routes into the same execution machinery. A death ligand at the surface, a mitochondrion that loses outer-membrane integrity, and a granzyme delivered by a cyto
PD-1 & PD-L1 Inhibitors(Post)PD-1 & PD-L1 interaction between T-cells and tumour cells. What are PD-1 and PD-L1? PD-1, also known as programmed cell death 1, is a receptor expressed on t
The double-edged sword in prostate cancer therapy(Post)By Zoe Angel, PhD Student, Ulster University Prostate cancer is now the commonest cancer in men and it is the fifth leading cause of death (1). Researchers h
M2 Supplement for Organoid Cell Culture: Enhancing Growth and Differentiation(Post)The use of M2 Supplement in organoid culture has revolutionized the way researchers cultivate and maintain these three-dimensional (3D) cellular models. Organoids—self-organizing cell clu
Enhancing Cancer Research: Syngeneic Mouse Models and Immune Checkpoint Inhibitors(Post)Enhancing Cancer Research: Syngeneic Mouse Models and Immune Checkpoint Inhibitors A quick guide to Syngeneic Mouse Models Syngeneic Mouse Models Cancer research has seen rema
Brodalumab: A Breakthrough in IL-17 Receptor Blockade for Psoriasis and Beyond(Post)Quick Facts About BrodalumabWhat is Brodalumab?Brodalumab is a monoclonal antibody that targets the IL-17 receptor to treat immune-mediated conditions like moderate-to-severe plaque psor
Spike-Recovery-ELISA: Protokoll, Berechnung und Akzeptanzgrenzen(Post)Spike-Recovery-ELISA: Protokoll, Berechnung und Akzeptanzgrenzen Spike-Recovery prüft, ob Ihre Probenmatrix die ELISA-Messung verfälscht. Sie versetzen eine bekannte Menge Antigen in Ihre Probe und p
NK Cell Licensing and Missing-Self(Page) How does Acute Myeloid Leukaemia start?(Post)I have been in the situation that I’m sure many of us have. I work on genes, which if you name to any right-minded individual, sound like a random string of nonsensical gibberish. So, maybe
Lorvotuzumab: Targeting CD56 in Cancer Research and Therapeutic Development(Post)Quick Facts About LorvotuzumabWhat is Lorvotuzumab?Lorvotuzumab is an antibody-drug conjugate (ADC) designed to target CD56, a surface antigen commonly overexpressed in neuroendocrine tu
Understanding activating PIK3CA mutations in human disease(Post)Ralitsa R. Madsen – University of Cambridge Metabolic Research Laboratories Each one of us is the result of an extraordinary developmental proces
CD31: A Comprehensive Look at an Essential Biomarker(Post)What is CD31? CD31, also known as PECAM-1, was originally described as a cell surface antigen present on platelets and megakaryocytes. CD31 is