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Streptococcus pneumoniae: Pathogenesis, Diagnosis, and Treatment(Post)
Microbiology · Bacterial PathogensStreptococcus pneumoniae: Pathogenesis, Diagnosis & TreatmentStreptococcus pneumoniae (the pneumococcus) is a Gram-positive, encapsulated bacterium that colonises the
Phosphatases and PTP1B – Mini review(Post)IntroductionThe human kinome is estimated to contain 518 genes, in comparison to the estimated 180 genes that comprise the phosphatome (Arena et al., 2005). These kinase genes represent a signif
Varlilumab: Unlocking CD27’s Potential in Cancer Research(Post)What You Need to Know About VarlilumabWhat is Varlilumab?Varlilumab is a monoclonal antibody targeting CD27, a receptor on T-cells that plays a critical role in immune modulation.What is
Bcell germinal centre pathway(Page) The Exciting Field of Stem Cell Research(Post)What are Stem Cells? Stem cells are primitive, undifferentiated, and unspecialised cells that are found in multicellular organisms
T cell Immunophenotyping - A Guide(Post)Immunology · Flow CytometryT Cell Immunophenotyping: Markers, Subsets and Panel DesignImmunophenotyping identifies cell populations by the proteins on their surface. For T cells that means resolving n
Glucose Assay Saliva Troubleshooting: Fixing Low Readings(Post)Quick answer A researcher measuring glucose in human saliva on the fluorometric procedure of a glucose assay kit had a textbook standard curve, yet every sample read far below the expe
Promising COVID-19 Therapeutics(Post)SARS-CoV-2, the causative viral agent of the novel coronavirus disease COVID-19, has sparked a global effort for creating prophylactic and therapeutic interventions. The following
B-Cell Receptor Signalling and the Germinal Centre Reaction(Post)The germinal centre is where antibody quality is made. A naive B cell that binds antigen does not become a source of protective, high-affinity IgG by accident. It passes through a tightly choreograph
Kreuzreaktivität ELISA: Praxisleitfaden für Forschende(Post)Kreuzreaktivität ELISA: Praxisleitfaden für Forschende Kreuzreaktivität im ELISA bedeutet, dass ein Antikörper an ein strukturell ähnliches Nicht-Ziel bindet und dadurch falsch-positive oder verfälsc
COVID-19 Vaccine Candidates(Post)What is COVID-19 COVID-19, the disease caused by the coronavirus named SARS-CoV-2, first identified in Wuhan, China in December 2019 has spre
LAG-3: Revitalizing T Cells in Exhaustion for Combination Therapies(Post)Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target fo
Ubiquitin and Its Role in Cellular Regulation: A Comprehensive Overview of Modifiers and Pathways(Post)Ubiquitin is a small, highly conserved protein found in eukaryotic cells that plays a crucial role in regulating various cellular processes. The process of ubiquitination involves the covalent att
Agarose vs Polyacrylamide: A Comparative Analysis(Post)Techniques · Gel ElectrophoresisAgarose vs Polyacrylamide: A Comparative AnalysisAgarose and polyacrylamide are the two workhorse gel matrices of electrophoresis. Agarose gels resolve larger DNA and R
PVR: Balancing Immune Activation and Suppression in Cancer(Post)PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a r
Anifrolumab: Transforming Lupus Treatment with Targeted Immunotherapy(Post)Quick Facts About AnifrolumabWhat is Anifrolumab?Anifrolumab is a monoclonal antibody that targets the type I interferon receptor, playing a crucial role in treating systemic lupus eryth
Understanding T Cell Fatigue: Implications for Immune Function and Therapeutic Interventions(Post)T cells are central players in adaptive immunity, responsible for recognizing and eliminating infected or aberrant cells. Upon encountering antigens, T cells undergo clonal expansion and differ
In Vivo Functional Grade Antibodies(Page) Bone Resorption Explained: Process, Markers, and Clinical Insights(Post)Bone Biology · BiomarkersBone Resorption: Process, Markers & Clinical SignificanceBone resorption is the process by which osteoclasts break down bone tissue and release its stored minerals into the bl
Allorecognition, Transplant Rejection & GvHD(Page)