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NK Cells: Unlocking the Potential of Natural Killer Cells in Cancer Therapy(Post)
Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill cance
Immunoglobulin vs Antibody: Unveiling the Intricacies(Post)In the realm of immunology, the terms "immunoglobulin" and "antibody" often find themselves used interchangeably, sparking confusion among those keen on understanding the immune system's fine deta
Cytokine Neutralisation In Vivo: Targets, Signals and Antibodies(Post)Almost any inflammatory phenotype in a mouse can be assigned to a cytokine by taking that cytokine away. Neutralisation is the most direct causal test immunology has: inject a functional-grade antibo
Fluorescence spectroscopy: An early detection tool for cancer.(Post)Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early underst
Unraveling the Complexity of the Notch Signaling Pathway: A Key Player in Development and Disease(Post)The Notch signaling pathway is a highly conserved cellular communication system that plays a crucial role in various biological processes, including embryonic development, tissue homeostasis, a
Understanding CD16: A Comprehensive Overview(Post)CD16, also known as FcγRIII (Fc gamma receptor III), plays a crucial role in the immune system, serving as a receptor for the Fc region of immunoglobulin G (IgG). This receptor is a key player in
One Integrin Chain, Two Partners, Brain or Gut(Post)A chemokine gradient does not move a leukocyte anywhere. It only tells one that has already stopped which way to go. That sentence is the whole map. Trafficking is a four-step cascade and the steps a
Androgenic steroid action in breast cancer(Post)By Rachel Bleach, PhD Student, RCSI By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reported
Plasma Membrane Markers(Post)What is a Plasma Membrane? The plasma membrane, also known as the cell membrane, is a vital component of all cells. It is a thin, semi-permeable barrier that separate
Key Players in T Cell Regulation: Lag-3, Tim-3, and TIGIT(Post)Understanding Lag-3, Tim-3, and TIGIT: Key Players in T Cell RegulationThe immune system's ability to regulate T cell responses is crucial for maintaining homeostasis and combating diseases such as ca
Innate Lymphoid Cells: ILC1, ILC2 & ILC3(Page) The Intestinal Barrier: Junctions, Mucus and Permeability(Page) Ras signaling pathway(Post)A wide variety of cell surface receptors activate Ras GTPase, including the tyrosine receptor linked to the epidermal growth factor receptor (EGFR) (Wells 1999). Upon receptor stimulation, son o
TIGIT, DNAM-1 and the CD155 Axis: Pathway, Function and Assays(Post)CD155 is read by four different receptors, and only one of them turns the killing programme on. The nectin and nectin-like ligands induced on stressed and transformed cells are simultaneously an acti
Understanding CD16: A Comprehensive Overview(Post)CD16, also known as FcγRIII (Fc gamma receptor III), plays a crucial role in the immune system, serving as a receptor for the Fc region of immunoglobulin G (IgG). This receptor is a key player in
Regulatory T Cells and the IL-2 Paradox(Page) The Role of Claudins in Cancer (Post)Introduction Claudins are a family of proteins that play a critical role in the formation of t
Biofilms: The Bacteria Invaders You Can't Ignore(Post)If you've ever had a urinary tract infection, you know all about bacteria. These tiny organisms can invade your body and cause all sorts of problems. But what you may not know is tha
IL-1 Family Signaling: Unraveling the Molecular Orchestra of Immune Regulation(Post)The Interleukin-1 (IL-1) family represents a crucial group of signaling molecules that play a pivotal role in regulating the immune system and inflammatory responses. Comprising 11 members, inc
CD155: Breaking Immune Suppression in Tumor Environments(Post)Introduction to CD155 in Cancer ImmunotherapyCD155, also known as Poliovirus Receptor (PVR), is a transmembrane protein that plays a pivotal role in tumor immune evasion. While CD155 is n