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By Rachel Bleach, PhD Student, RCSI By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reported

Quick Facts About NaratuximabWhat is Naratuximab?Naratuximab is an anti-CD37 monoclonal antibody-drug conjugate (ADC) designed to target B-cell malignancies, particularly non-Hodgkin lym

Progression of the JAK STAT Signalling Pathway Cellular communication is a complex network of molecular interactions that govern various physiological processes. Among the many signal

By Charlotte O'Donnell PhD The genes of the IL-36 family members are located in a cluster on chromosome 2 [1]. All three activating ligands, IL-36α, IL-36β a

MST2/Hippo PathwayMammalian Sterile Twenty (MST) pathways have been identified as a homologue of the ste20 kinase from Saccharomyces cerevisiae (Creasy and Chernoff 1995). The MST2/Hippo pathway

Imagine a highly trained soldier, elite and effective, sent to the front lines of a relentless war. Day after day, they fight without rest, their supplies dwindle, and the enemy never stops coming. Ev

Immunology · Myeloid CellsGranulocytes: Neutrophils, Eosinophils and BasophilsGranulocytes are the leukocytes with cytoplasmic granules and lobed nuclei — neutrophils, eosinophils and basophils. They

Lipid Metabolism Assay Kits | Cholesterol, Fatty Acids & Bile Acids | Assay Genie

The MycoGenie Rapid Mycoplasma Detection Kit enables the detection of 28 Mycoplasma species in under 1 hour using a simple visual determination method, eliminating the need for expensive

Cell Signalling · Kinase CascadesMAPK Signaling: The Pathway of Mitogen StimulationThe mitogen-activated protein kinase (MAPK) pathway is one of the most important signalling cascades in biology, conv

Quick Facts About Rovalpituzumab TesirineWhat is Rovalpituzumab Tesirine?Rovalpituzumab Tesirine (Rova-T) is an antibody-drug conjugate (ADC) designed to target DLL3, a protein overexpre

Sarah Brun Bar-Yaacov PhD Candidate, University of Liverpool Orthohantaviruses are a group of segmented negative-sense RNA viruses maintained as asympto

The Complement System Function Gone are the days when the complement system was considered solely a companion of its impressive adaptive immune system counte

Phosphorothioate is a chemical modification commonly used in oligonucleotide-based therapies to enhance the stability and efficacy of therapeutic nucleic acids. In this modification, one

Inflammasomes are complex intracellular structures that play a pivotal role in the immune response by detecting pathogenic microorganisms and sterile stressors. Their activation is a critical step

An agonist antibody does not activate its receptor. It gets held still by something else, and the receptors underneath cluster because they are crowded. That sentence sounds like a technicality and i

ELISA-Platten beschichten: Protokoll, Puffer und Fehlerquellen ELISA-Platten beschichten bedeutet, Antikörper oder Antigene passiv auf Polystyrol-Wells zu immobilisieren, um eine reproduzierbare Bind

Glucocorticoid-induced tumor necrosis factor receptor (GITR) is an immune checkpoint molecule that plays a crucial role in regulating T cell activation and survival. In recent years, GITR