10738 results for 'IL-29/IL-28B (IFN-lambda 1/3)'

What You Need to Know About VopratelimabWhat is Vopratelimab?Vopratelimab is an experimental monoclonal antibody that targets the Inducible T-cell CO-Stimulator (ICOS) protein, playing ...

What You Need to Know About CabiralizumabWhat is Cabiralizumab?Cabiralizumab is a monoclonal antibody targeting the colony-stimulating factor-1 receptor (CSF1R), developed for treating ...

Harnessing the immune system to fight cancer has become a pivotal strategy in modern oncology. A key component in this fight is CD27, a receptor that plays a crucial role in T-cell activ ...

Introduction to TNFRSF9 and Its Role in Immune ActivationTNFRSF9, also known as 4-1BB or CD137, is a co-stimulatory receptor expressed on the surface of T cells, natural killer (NK) cell ...

Laura Menke PhD candidate, Queen Mary University of London Inflammation vs. Resolution Atherothrombosis is the leading cause of death worldwide ...

Antibodies, or immunoglobulins, stand as critical components of the immune system, orchestrating the identification and neutralization of pathogens like viruses and bacteria. This extensive arti ...

Immunoglobulins (Igs), also known as antibodies, are glycoproteins produced by B cells and plasma cells. They play a central role in the immune system by identifying and neutralizing pat ...

This article breaks down the glycoprotein Granulocyte-macrophage colony-stimulating factor (GM-CSF) detailing its structure, function and therapeutic uses. It also describes its role in im ...

Flow cytometry stands as a pivotal technique in the realms of molecular biology and immunology, enabling the analysis of physical and chemical characteristics of cells or particles as they flow i ...

Quick Facts About FletikumabWhat is Fletikumab?Fletikumab is an investigational monoclonal antibody targeting CD47, a key immune checkpoint that enables cancer cells to evade immune des ...

By Pietro Maria Bertelli, PhD Candidate, Queens University Belfast Introduction Eye complications are very frequent in patients with diabetes, a ...

Apoptosis Unveiled: Your Complete Guide to Intrinsic & Extrinsic PathwaysAt Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis!K ...

What is Cortisol? Cortisol is a steroid hormone, classified as a member of the glucocorticoid family of hormones. Cortisol is involved in a plethora of physiological processes in order ...

The Spanish flu pandemic of 1918-1919 was the deadliest in history. It is estimated that up to 100 million people died from the virus, which is more than three times the number who ...

by Ryan Wallis, PhD Aging and Disease Imagine a world where everything you do is missing just a little piece and as time goes on you start to lose sense entirely. This is the dev ...

At Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis! Key Takeaways: Apoptosis is a programmed cell death process, vital for tissu ...

Introduction to KIR Blockade in Cancer ImmunotherapyNatural killer (NK) cells are crucial components of the innate immune system, responsible for recognizing and destroying virally infe ...

Introduction Transformation of bacteria with plasmids is not only of note for bacterial studies but also can be used for gene expression studies in mammalian cells. Most plasmids are of bac ...

Introduction to CD86 and Its Role in Immune Activation CD86 is a crucial co-stimulatory molecule that plays an essential role in T cell activation, driving the immune system’s abili ...

Quick Facts About UlviprubartWhat is Ulviprubart?Ulviprubart is an experimental complement inhibitor designed to modulate immune responses in autoimmune diseases.What is the mechan ...

Quick Facts About AvizakimabWhat is Avizakimab?Avizakimab is a monoclonal antibody designed to target the CD47 protein, a key checkpoint in immune regulation, particularly in cancer the ...

Test COVID-19 rapide POC Description Le kit Assay Genie à utilisation seulement p ...

What are Autoimmune Diseases? Autoimmune diseases are a diverse group of disorders where the immune system mistakenly attacks the body's own cells, tissues, and organ ...

The Role of CTLA-4 in Breast Cancer: Implications for ImmunotherapyBreast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, with significant morbidity and mortalit ...

Understanding the differentiation pathways of neural stem cells (NSCs) and the identification of lineage-specific markers is a cornerstone in the field of neurobiology and regenerative medicine.

Imagine a living drug, engineered from a patient's own immune system, that can hunt down and destroy cancer cells with remarkable precision. This isn't science fiction; it's the reality of Chimeric A ...

What You Need to Know About BermekimabWhat is Bermekimab?Bermekimab is a monoclonal antibody targeting the CD47 receptor, developed to modulate the immune system and improve conditions ...

Key Facts About EtigilimabWhat is Etigilimab?Etigilimab is an anti-TIGIT monoclonal antibody being studied for its potential role in cancer immunotherapy.What role does Etigilimab play ...

For decades, we viewed cancer as a rogue army of cells, a biological glitch driven solely by genetic mutations and metabolic greed. We imagined tumors as isolated fortresses, growing in a vacuum of ...

Myrna Hurtado, PhD Student, University of North Texas Health Science Center Advancements in modern medicine have resulted in significantly prolonging and ...

Introduction to CD80 and Its Role in Immune Activation CD80 is a critical immune checkpoint molecule that plays an essential role in T cell activation through co-stimulatory pathway ...

PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a ...

For years, the success of CAR-T cell therapy has been a beacon of hope in the fight against blood cancers, offering remarkable remissions where other treatments have failed. Yet, solid tumors—the for ...

Delve into the pivotal role of Neurofilament Light chain (NEFL) in neuron structure and its emerging importance as a biomarker for various neurodegenerative diseases, offering insights into di ...

Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis (IPF) is a chronic, irreversible and ultimately fatal disease characterized by pro ...

Introduction Cellular senescence is a fascinating phenomenon that plays a crucial role in the aging process and various age-related diseases. It is essential to explore the cellular ...

The Role of CD25+FOXP3+CD45RA- Treg Cells in Cancer PrognosisIntroductionRegulatory T-cells (Treg cells) are a specialized subset of T-cells that play a pivotal role in maintaining immune homeostasis ...

PD-L1 in Cancer Immunotherapy: Insights from Recent ResearchRecent advancements in cancer immunotherapy have underscored the critical role of programmed death-ligand 1 (PD-L1) in mediating immune eva ...

CD8+ T cells, also known as cytotoxic T lymphocytes (CTLs), are a critical component of the immune system. They play a vital role in defending the body against viral infections, intracel ...

Quick Facts About AnifrolumabWhat is Anifrolumab?Anifrolumab is a monoclonal antibody that targets the type I interferon receptor, playing a crucial role in treating systemic lupus eryt ...

Objectives & Key Results Objectives & Key Results (OKRs) is a framework for setting and tracking goals. At Assay Genie, we've tailored this approach to sui ...

Protein kinase B or AKT (PKB) is a serine/threonine kinase. In mammals it is comprised of 3 highly homologous isoforms PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) (Manning and Cantley 2007). AKT ...

Introduction to CD155 in Cancer ImmunotherapyCD155, also known as Poliovirus Receptor (PVR), is a transmembrane protein that plays a pivotal role in tumor immune evasion. While CD155 is ...

Introduction to BTLA in Immune Regulation B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that plays a critical role in regulating immune responses by suppress ...

Understanding Myeloid Cell Networks in Cancer ImmunotherapyImmunotherapy has revolutionized cancer treatment, yet its effectiveness in re-establishing original immune responses post-therapy remains l ...

For decades, the fight against cancer has been a grueling battle of attrition, with treatments often as harsh as the disease itself. But a revolutionary approach, chimeric antigen receptor (CAR)-T ce ...

Hypoxia, or low oxygen levels, poses a significant challenge to cells, necessitating rapid and efficient adaptation mechanisms. The Hypoxia-Inducible Factor (HIF) pathway is a well-known regul ...

Discover the distinct roles of 'In Vivo' and 'In Vitro' in biological research, where one offers a natural context and the other precise control, both vital for scientific advancement.

Writing a Thesis Statement Writing a thesis statement can be a frustrating task, whether you're working on your undergraduate, master's, or PhD degree. Unfortunatel ...

B Cell Types, Antigen Recognition & Activation A comprehensive guide to B cells! Introduction B cells, a vital component of the immune system, ...

Immune evasion is one of the hallmarks of cancer, where tumor cells employ various strategies to suppress immune responses and prevent destruction by the body’s defense systems. CD200, a ...

By Rachel Bleach, PhD Student, RCSI By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reporte ...

In Vitro vs In Vivo: Complete Comparison + Selection Guide | Research MethodsDiscover the distinct roles of 'In Vivo' and 'In Vitro' in biological research, where one offers a natural co ...

By Anusha Senevirante, Post-Doctoral researcher, Imperial College London With non-communicable diseases (or NCDs, which include heart disease, diabetes, c ...

What is Cell Synchronisation? Cell synchronisation is a process by which cells at different stages of the cell cycle in a culture are brought to the same phase. Cell synchronisation is ...

Imagine engineering a patient's own immune cells into precision-guided missiles against cancer—cells that can seek out and destroy tumors with remarkable specificity. This is the promise of CAR-T cel ...

By Sinead Kinsella PhD The Ubiquitin Proteasome System (UPS) The Ubiquitin Proteasome System (UPS) is a regulatory machinery for protein turnover in ...

Exploring sepsis: a critical imbalance in the immune response to infection. Key Takeaways: Sepsis is a severe, immune-driven response to infection causing systemic inflammation and poten ...

Hybridoma cells are essential tools for producing monoclonal antibodies and are derived by fusing B lymphocytes (antibody-producing cells) with myeloma cells (cancer cells) to achieve bo ...

The MycoGenie Rapid Mycoplasma Detection Kit enables the detection of 28 Mycoplasma species in under 1 hour using a simple visual determination method, eliminating the need for expensiv ...

Waardenburg Syndrome: A Rare Genetic Disorder Affecting Pigmentation, Hearing, and More Waardenburg Syndrome (WS) is a fascinating and rare genetic disorder that impacts various asp ...

Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early unders ...

Enhancing Cancer Research: Syngeneic Mouse Models and Immune Checkpoint Inhibitors A quick guide to Syngeneic Mouse Models Syngeneic Mouse Models Cancer research has seen rem ...

Key Points Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a method of gene editing that uses ...

Quick Facts About IcrucumabWhat is Icrucumab?Icrucumab is a monoclonal antibody that targets vascular endothelial growth factor receptor-1 (VEGFR-1) to inhibit tumor angiogenesis.How Do ...

By Francisco Algaba Chueco In this post we discuss a topic that everyone will have heard of. Let’s talk about migraines, a disorder that hides a huge p ...

Immunotherapy has revolutionized cancer treatment by harnessing the body's immune system to fight malignancies. Among the notable advancements in this field is the development of immune ...

The Assay Genie 3D Organoid Cell Viability Assay (AKES081) provided superior results compared to ThermoScientific PrestoBlue, maintaining over 100% viability at all time points in untre ...

In recent years, the field of oncology has witnessed a paradigm shift with the advent of immunotherapy, a treatment modality that harnesses the body's immune system to combat cancer. Among the mo ...

Shelly Pathak PhD candidate, University of Leeds SAIDs Systemic Auto-inflammatory diseases (SAIDs) have been defined as a group of mainly inherited disorde ...

Quick Facts About Ladiratuzumab VedotinWhat is Ladiratuzumab Vedotin?Ladiratuzumab Vedotin is an antibody-drug conjugate (ADC) designed to target LIV-1, a protein commonly expressed in ...

By Shane Houston, PhD Candidate Queen’s University Belfast Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health ...

Key Facts: PembrolizumabIs Pembrolizumab Safe?Pembrolizumab is widely recognized as safe for most patients, with side effects ranging from mild to severe. Commonly reported side effects ...

Both Assay Genie MORV0010 and Promega E1910 effectively quenched Firefly luciferase before Renilla detection, minimizing signal overlap. E1910 achieved 99.95% quenching efficiency, whil ...

The mammalian target of rapamycin (mTOR) signaling pathway is a crucial regulator of cell growth and metabolism, responding to environmental cues and cellular energy status. This pathway's signif ...

Pancreatic cancer survival rates Despite recent advances in our understanding of this disease, pancreatic cancer is one of the world’s most lethal maligna ...

Microglia Astrocytes Oligodendrocytes Glial ...

The angiotensin pathway is a pivotal hormonal system that plays a crucial role in regulating blood pressure and maintaining fluid and electrolyte balance within the body. This complex biochemical ...

TIGIT (T cell immunoreceptor with Ig and ITIM domains) has emerged as a promising target in cancer immunotherapy and the treatment of autoimmune diseases. As a checkpoint receptor, TIGIT ...

Platelets, the tiny cellular fragments found in our blood, play a crucial role in maintaining our overall health and well-being. From their role in blood clotting to their involveme ...

Áreas clave de resolución de problemas de ELISA: Señal alta: Una señal alta puede ocurrir por numerosas razones, incluyendo un lavado insuficiente de la placa, no ...

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Co-stimulatory and Co-inhibitory Molecules in Adaptive Immunity The adaptive immune system is in part regulated by a vast array of co-stim ...

Cell-Based ELISA Kits No More Western Blots! Over 1,600 Cell-Based ELISA kits to measure the relative levels of intracellular and phosphorylat ...

Assay Genie has developed an extensive suite of assays to measure various forms of cell death. We provide highly sensitive & reprod ...

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What is RIPA Buffer? RIPA (Radio Immuno Precipitation Assay) buffer is primarily used when conducting a western blot or immunoprecipatation assay. A RIPA buffer is used in order to l ...

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Co-immunoprecipitation Protocol A detailed guide of how Co-IP works, a step by step Co-IP protocol and some hints & tips for your Co-IP workflow! Introductio ...

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Mycoplasma Testing Mycoplasma Detection & Elimination Kits Visually detect Mycoplasma by eye in 1 hour! View Validation h1.page-heading{ display: ...

COVID-19 Nasal Swab Test Nasal/Nasopharyngeal Swabs for Viral Sample Collection The developme ...

Phosphorylation ELISA Screen cell lysates without Western Blot analysis! Determine phosphorylated protein to verify pathway activation! ...

The Ultimate Western Blot Guide At Assay Ge ...

What is Subcellular Fractionation? Subcellular fractionation is the process of iIsolating nuclear, cytosolic and mitochondrial fractions of high purity from tissues. Subcellular fracti ...

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