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By Eleni Chrysostomou, PhD Candidate, NUIG Why do we need to know how the Nervous System develops and regenerates? The structure and function of the n

IQGAP1: IQ-motif containing GTPase-activating-like protein-1 reviewIQ motif-containing GTPase-activating-like protein-1 (IQGAP1) is a 190 KDa protein that belongs to a conserved family of sc

Techniques · Apoptosis DetectionTUNEL Staining: The Method of Choice for Measuring Cell DeathTUNEL staining is a gold-standard technique for detecting apoptosis in situ. By labelling the fragmented DN

QUICK ANSWER A researcher ran a competitive 2,3-bisphosphoglycerate (2,3-BPG) ELISA on red blood cell (RBC) lysate. The standard curve was textbook, yet every lysate sample read at the

What are Stem Cells? Stem cells are primitive, undifferentiated, and unspecialised cells that are found in multicellular organisms

Cell counting is an important part of many different scientific experiments, enabling researchers to gather crucial data about cell populations and their characteristics. In this step-by-st

Introduction to TNFRSF9 and Its Role in Immune ActivationTNFRSF9, also known as 4-1BB or CD137, is a co-stimulatory receptor expressed on the surface of T cells, natural killer (NK) cells

Mitophagy, a term derived from the fusion of "mitochondria" and "autophagy," represents a vital cellular process responsible for the targeted degradation and recycling of dysfunctional mitochon

What is preeclampsia? According to the World Health Organization (WHO), one in ten pregnant women is affected by hypertensive disorders, and preeclampsia a

You are only part human. In some ways, you are as much bacteria as you are mammal, and in some ways bacteria make up far more of you than your own familiar cells and genes! It is becoming

Delving into the intricate world of Mitotic Catastrophe, this blog unveils its critical role in cell division and cancer therapy, offering insights into its mechanisms and potential treatments.

Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic res

Mesenchymal stem cells (MSCs) have emerged as pivotal players in the realm of regenerative medicine due to their unique properties and versatile potential. Originally discovered in the bone marrow

The germinal centre is where antibody quality is made. A naive B cell that binds antigen does not become a source of protective, high-affinity IgG by accident. It passes through a tightly choreograph

The inception of induced pluripotent stem cells (iPSCs) has heralded a new dawn in the realm of biomedical research and regenerative medicine, setting the stage for groundbreaking advancements in

Cell Culture · ProtocolsPassaging Hybridoma Cells: A Detailed GuideHybridomas are productive but temperamental. They grow in suspension, are sensitive to shear and to overgrowth, and — the problem tha

PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a r

You can remove almost every B cell from an animal and barely move its antibody titre. That is not a failed experiment — it is the expected result, and it follows from one fact: CD20 is switched off a