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Innate Viral Immunity & RIG-I in COVID-19(Post)
RIG-I: Antiviral Properties in COVID-19 (SARS-CoV-2) Infection Key Points RIG-I is a cytosolic RNA h
Targeting USP22 to Boost Anticancer Immunity(Post)Targeting USP22: A New Approach to Enhance Anticancer Immunity Introduction In the ever-evolving landscape of cancer research, the intricate relationship between immune e
CD47: Overcoming Tumor Evasion Through Macrophage Activation(Post)One of the greatest challenges in cancer therapy is how tumors evade immune detection. Among the mechanisms cancer cells exploit, the CD47 pathway has emerged as a major player in helping
Top 10 Universities in the UK(Post)Before I even started my PhD I was already thinking about carrying out PostDoc in a foreign country and had my sights set on going to the US. I had previously carried out a degree in Genetics
CAR-T Cell Signalling Pathway: Costimulation, Output and Assays(Post)A chimeric antigen receptor is a synthetic protein wired into a real signalling pathway. The extracellular half is an antibody fragment; everything below the membrane is borrowed from the T-cell rece
Polatuzumab: Redefining Targeted Therapies in B-Cell Lymphoma(Post)What You Need to Know About PolatuzumabWhat is Polatuzumab??Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b, a component of the B-cell receptor, used primarily in B-cel
Waardenburg Syndrome and Klein-Waardenburg Syndrome(Post)Waardenburg Syndrome: A Rare Genetic Disorder Affecting Pigmentation, Hearing, and More Waardenburg Syndrome (WS) is a fascinating and rare genetic disorder that impacts various aspe
Uliledlimab: Unveiling the Role of Anti-CD47 in Cancer Research(Post)Quick Facts About UliledlimabWhat is Uliledlimab?Uliledlimab is a monoclonal antibody targeting CD47, a checkpoint protein that helps tumors evade immune system detection. By blocking CD
Cellular Respiration: Stages, ATP Production & Pathway Guide(Post)Metabolism · Biochemistry Guide Cellular Respiration: Stages, ATP Production & Pathway Guide How cells convert glucose and oxygen into ATP acr
Excluding Doublets in FACS Analysis: A Comprehensive Guide(Post)Flow Cytometry · GatingExcluding Doublets in Flow Cytometry: Pulse Geometry and Gating StrategyTwo cells passing the laser together are recorded as one event, with roughly double the signal. In DNA co
Protein Glycosylation for Labs: Mechanisms, Workflows, and Reagent Tips(Post)Protein Glycosylation for Labs: Mechanisms, Workflows, and Reagent Tips Protein glycosylation is the enzymatic covalent attachment of sugar chains (glycans) to specific amino acid side chains, most co
Trastuzumab: Revolutionizing HER2-Positive Cancer Treatment & Research(Post)Quick Facts About TrastuzumabWhat is Trastuzumab?Trastuzumab is a monoclonal antibody used to treat HER2-positive breast and gastric cancers. It specifically targets the HER2 protein, re
Unlocking the Next Wave of Cancer Treatment: The Rise of CAR-T Cell Therapy(Post)A New Era in Oncology Chimeric Antigen Receptor (CAR)-T cell therapy represents a paradigm shift in the fight against cancer, offering a personalized and powerful immunotherapy that trains a patient
T-Cell Receptor Signalling: The Complete Pathway, Branch by Branch(Post)The T-cell receptor is the most finely calibrated detector in immunology. It must discriminate an agonist peptide present at a few dozen copies from a self peptide present at tens of thousands, and i
Biological Role of GLP-1(Post)Glucagon-like peptide-1 (GLP-1) is a critical hormone in the regulation of glucose metabolism and has garnered significant attention due to its therapeutic potential in managing diabetes
Bermekimab: Unveiling the Role of Anti-CD47 in Hidradenitis Suppurativa and Atopic Dermatitis(Post)What You Need to Know About BermekimabWhat is Bermekimab?Bermekimab is a monoclonal antibody targeting the CD47 receptor, developed to modulate the immune system and improve conditions l
ELISA High Background Troubleshooting: FBS Matrix Interference(Post)Quick answer A researcher running a Rat Eotaxin/CCL11 (Eotaxin) sandwich ELISA saw sample readings sit above the top standard and wells turn colour the instant TMB was added — even aft
Deciphering the Intricacies of TGF-Beta Signaling Pathway(Post)Transforming Growth Factor-Beta (TGF-β) signaling pathway plays a pivotal role in orchestrating various cellular processes, ranging from embryonic development to tissue homeostasis and immune resp
Comparison of Assay Genie Dual Luciferase Reporter Assay (MORV0010) vs Promega (E1910): Performance Evaluation of Quenching Efficiency and Auto-luminescence(Post)Both Assay Genie MORV0010 and Promega E1910 effectively quenched Firefly luciferase before Renilla detection, minimizing signal overlap. E1910 achieved 99.95% quenching efficiency, while
Delete Every Microglial Cell, Then Ask What Changed(Post)Block one receptor and more than 90% of the microglia in a mouse brain are dead within a week. Not impaired — gone. Stop the block and they come back, repopulating from the survivors within another w