10693 results for 'Orexin B/Hypocretin-2'

Understanding PD-1 Blockade in B-Cell Lymphomas Understanding PD-1 Blockade in B-Cell Lymphomas Introduction The programmed cell death prot ...

Understanding the Bcl-2 Pathway: Implications for Cancer Therapy The Bcl-2 family of proteins plays a pivotal role in regulating apoptosis, a crucial process for maintaining cellula ...

Exploring the realm of B cells, this piece delves into the intricacies of these white blood cells, pivotal in humoral immunity. Through the lens of CD markers and immunophenotyping, we unravel ...

The fight against B cell cancers, a challenging spectrum of hematologic malignancies, has entered a new era with the introduction of rituximab biosimilars. These biosimilars promise to extend th ...

In the relentless fight against cancer, immunotherapy has emerged as a beacon of hope, harnessing the body's own defenses to combat malignant cells. Yet, predicting which patients will respond to th ...

What You Need to Know About PolatuzumabWhat is Polatuzumab??Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b, a component of the B-cell receptor, used primarily in B-ce ...

B Cell Types, Antigen Recognition & Activation A comprehensive guide to B cells! Introduction B cells, a vital component of the immune system, ...

Breakthrough Discovery: Epstein-Barr Virus Identified as Primary Trigger for Lupus A groundbreaking study published in November 2025 has provided the most definitive evidence to date that the common ...

Structure, Function, and Detection Assays for COVID-2019 Background The global spread of the novel co ...

Rapid Antibody & Antigen tests available from Assay Genie ...

LATS kinases belong to a family of proteins that, in mammals, are comprised of two isoforms, LATS1 and LATS2. Originally identified in Drosophila melanogaster as Warts kinase, LATS1 and LATS2 s ...

What is the Coronavirus Spike Protein? COVID-19, the newest coronavirus to gain international attention, is caused by severe acute respirato ...

PCR Detection of COVID-19 (SARS-CoV-2) Contents Background Assay Information Sample Types   & ...

SARS-CoV-2 qPCR assay from Assay Genie Assay Genie have just launched a qPCR assay for the detection of SARS-CoV-2. The SARS-CoV-2 One-Step RT-qPCR Kit for Cor ...

The orchestration of angiogenesis, the process by which new blood vessels form from pre-existing ones, is a complex symphony regulated by various molecular players. At the forefront of this in ...

Transmission of SARS-CoV-2 (COVID-19) via Droplets and Aerosols What is COVID-19? COVID-19, the dise ...

Quick Facts About NarsoplimabWhat is Narsoplimab?Narsoplimab is a human monoclonal antibody that targets MASP-2, a key enzyme in the lectin pathway of the complement system.What is the ...

CB6, also known as Etesevimab, is a monoclonal antibody that targets the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. It neutralizes the virus by preventing it from bin ...

주요 포인트: COVID-19,SARS-COV-2에의한 유행성 코로나 바이러스 질환은 예비 데이터에 따르면, 전형적인 혈청 전환 및 면역 글로불린 클래스 (이소형) 전환 시간 과정을 따르는 것으로 나타났다. 증상 발병 2 주 후 임상 중증도와 ...

SARS-CoV-2 검사 키트-코로나 바이러스 검사를위한 원스텝 RT-qPCR 키트 (2019-nCoV 종) 강력하고 재현 가능한 원스텝 코로나 바이러스 검사 (2019-nCoV종) ...

  کیت تشخیص SARS-CoV-2 - کیت RT-qPCR یک مرحله ای برای تشخیص Coronavirus (Strain 2019-nCoV) ...

COVID-19（SARS-CoV-2）トリプレックスRT-qPCR検出キット COVID-19アッセイの概要： この製品は、新規コロナウイルスSARS-CoV-2によって引 ...

What You Need to Know About InebilizumabWhat is Inebilizumab?Inebilizumab is a humanized monoclonal antibody that targets CD19, a protein expressed on B cells, to treat autoimmune disea ...

Quick Facts About PinatuzumabWhat is Pinatuzumab?Pinatuzumab is an antibody-drug conjugate (ADC) designed to target CD22, a protein highly expressed on B-cell malignancies, including no ...

SARS-CoV-2 Background COVID-19 is characterised by a series of biological markers. In some instances, these biomarkers can be used as potent ...

Quick Facts About RituximabWhat is Rituximab?Rituximab is a monoclonal antibody targeting CD20, a protein found on the surface of B cells. It plays a crucial role in treating autoimmune ...

Interleukin-9 (IL-9) plays a critical role in the immune system, influencing a variety of biological functions across different immune cell types. This article provides an in-depth look at the si ...

A wide variety of cell surface receptors activate Ras GTPase, including the tyrosine receptor linked to the epidermal growth factor receptor (EGFR) (Wells 1999). Upon receptor stimulation, son ...

Immunoglobulins (Igs), also known as antibodies, are glycoproteins produced by B cells and plasma cells. They play a central role in the immune system by identifying and neutralizing pat ...

What is Wnt Signalling? The Wnt signalling pathway is an evolutionarily conserved pathway that plays critical roles in the regulation of determining cell ...

Immune Regulation in COVID-19: Immunomodulatory Mechanisms against SARS-CoV-2 Infection What is COVID-19? ...

Explore the complexities of Interleukin-10 (IL-10) signaling and regulation, a crucial aspect in immune response modulation and its dual roles in cancer development and therapy. Key Takeaways ...

血管紧张素转换酶II（ACE2）活性测定试剂盒（荧光） 血管紧张素转换酶II（ACE2）活性测定试剂盒（荧光） 血管紧张素转化酶II（ACE2，EC 3.4.17.23）是一种基 ...

Quick Facts About IanalumabWhat is Ianalumab?Ianalumab is a monoclonal antibody currently being investigated for its potential in treating autoimmune diseases, particularly lupus and im ...

Quick Facts About ObinutuzumabWhat is Obinutuzumab?Obinutuzumab is a monoclonal antibody targeting CD20, primarily used in treating B-cell malignancies such as chronic lymphocytic leuke ...

What is a vaccine? A vaccine is a pharmacological product that gives the recieving patient's immune system a chance to learn how to fight infection with decreased risk of illness. Vacc ...

What are Natural Killer Cells? Natural Killer (NK) cells are a vital subset of lymphocytes, belonging to the same family as B cells and T cells, collectively known a ...

Quick Facts About BelimumabWhat is Belimumab?Belimumab is a monoclonal antibody used to treat systemic lupus erythematosus (SLE), an autoimmune disease. It is marketed under the brand n ...

CD Markers Cluster of Differentiation (CD) markers play an important role in the differentiation of B cells, T cells and NK (natural killer) c ...

Cyclins and CDKs are central to cell cycle control, with specific cyclin-CDK pairs regulating different phases, ensuring orderly progression and genomic integrity in cell division. Key Takeaw ...

Quick Facts About NaratuximabWhat is Naratuximab?Naratuximab is an anti-CD37 monoclonal antibody-drug conjugate (ADC) designed to target B-cell malignancies, particularly non-Hodgkin ly ...

What are MHC Class I molecules? The MHC class I is a glycoprotein that is expressed on all nucleated cells of the human body. MHC class I are important in disease defense against viruses, b ...

Incidence rate of Acute Lymphoblastic Leukaemia Acute lymphoblastic leukaemia (ALL) is one of the most common malignant diseases diagnosed in children. It ...

Acetylation, a chemical process characterized by the addition of an acetyl functional group to a molecule, stands as a cornerstone in both biochemical and biological landscapes. Its significan ...

Immunoglobulin antibodies stand at the forefront of the immune defense system, offering a sophisticated mechanism for recognizing and neutralizing a vast array of pathogens, including bacteria, ...

Antibodies, or immunoglobulins, stand as critical components of the immune system, orchestrating the identification and neutralization of pathogens like viruses and bacteria. This extensive arti ...

Apoptosis Unveiled: Your Complete Guide to Intrinsic & Extrinsic PathwaysAt Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis!K ...

What is Cystic Fibrosis? Cystic fibrosis (CF) is a genetic disorder that impairs the body's ability to produce sweat and thick mucus. CF causes mucus to build up in ...

Introduction to MAPK Signaling in Cellular Processes Mitogen-Activated Protein Kinase (MAPK) signaling pathways are crucial in transmitting signals from the cell surface to the DNA in the c ...

By Juan Quintana, PhD student, University of Edinbrugh What are Neglected Tropical Diseases (NTDs)? The World Health Orga ...

What is pharmacogenomics Pharmacogenomics is how DNA variation and drugs interact and how this can optimise patient health; this involves studying pharmacokinetics and pharmacodynamics ...

Seroconversion Implications in SARS-CoV-2 Diagnostic Testing Key Points: COVID-19, the pandemi ...

CD40, a member of the tumor necrosis factor receptor (TNFR) superfamily, plays a pivotal role in regulating immune responses, particularly in activating antigen-presenting cells (APCs) a ...

T Cell Types, Activation, Polarization & Function A comprehensive guide to T cells! window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); wi ...

COVID-19 Antibody Testing Antibody Production in COVID-19 COVID-19, the novel coronavirus disease ...

The Complement System Function Gone are the days when the complement system was considered solely a companion of its impressive adaptive immune system count ...

By Pietro Maria Bertelli, PhD Candidate, Queens University Belfast Introduction Eye complications are very frequent in patients with diabetes, a ...

SARS-CoV-2用検出キット-コロナウイルス検出用RT-qPCRワンステップキット（2019-nCoV系統） 堅牢かつ再現性の高いワンステップコロナウイルス検出（2019-nCoV系統）製品の概要： ...

Hepatocellular carcinoma (HCC) is one of the most frequently occurring cancers and there are 630,000 new cases diagnosed every year worldwide (De Minicis et al. 2013). HCC develops frequently f ...

Exploring the multifaceted role of dendritic cells in immune function and disease. Key Takeaways DCs are professional antigen-presenting cells that capture, process, and pres ...

Hybridoma technology, a revolutionary method in immunology pioneered by Georges Köhler and César Milstein in the 1970s, has transformed the landscape of antibody production. This groundbreaking t ...

T cells are central players in adaptive immunity, responsible for recognizing and eliminating infected or aberrant cells. Upon encountering antigens, T cells undergo clonal expansion and diffe ...

Immunophenotyping by Flow Cytometry Immunophenotyping is a technique used in the field of immunology and cell biology to identify and classify cells based on the specific proteins ...

SARS-CoV-2检测试剂盒──用于冠状病毒检测（2019-nCoV株）的一步式RT-qPCR试剂盒 用于可靠且可再生的一步式冠状病毒检测（2019-nCo ...

BDNF Overview Brain-derived neurotrophic factor (BDNF) is a central mediator of neuroplasticity, a term used to describe the ability of neuron ...

Delving into the intricate world of Mitotic Catastrophe, this blog unveils its critical role in cell division and cancer therapy, offering insights into its mechanisms and potential treatments ...

Major Histocompatibility Complex (MHC) molecules are essential for immune recognition and response. They are specialized glycoproteins that present antigens to T cells, allowing the immu ...

Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

Toll-Like Receptors The innate immune response has come under the spotlight in recent years due to its central role in propagating the pathoge ...

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Nod-like receptors Nod like receptors (NLRs) are a versatile family of relatively recently discovered intracellular receptors which have a b ...

Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...

What You Need to Know About OzuriftamabWhat is Ozuriftamab?Ozuriftamab is an investigational monoclonal antibody targeting CD47, designed to enhance immune-mediated clearance of cancer ...

Platelet adhesion is a critical process in the maintenance of hemostasis, the body's response to bleeding. This intricate process involves a series of interactions between platelets, the cellular ...

At Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis! Key Takeaways: Apoptosis is a programmed cell death process, vital for tissu ...

The innate immune system, a primary line of defense against pathogens, comprises various cellular and molecular mechanisms. Among these, the Nod-like Receptor (NLR) signaling pathways play a crit ...

The human body is a complex and intricate system where various components work together to maintain health and combat potential threats. Among these essential players are the TNF cy ...

Mononuclear phagocytes, essential in immunity and homeostasis, perform diverse roles from phagocytosis to tissue repair, influencing health and disease. Key Takeaways: Mononuclear ...

By Shane Houston, PhD Candidate Queen’s University Belfast Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health ...

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COVID-19 COVID-19, the newest coronavirus to gain international attention, is caused by severe acute respiratory syndrome coronavirus 2. The most common abbrev ...

PharmaGenie ELISA Validated According to ISO Quality Systems Highly validated ELISA designed to exceed the needs of biopharma R&D s ...

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COVID-19 Throat Swab Test Throat/Oropharyngeal Swabs for Viral Sample Collection The development of diagnostic tests for COVID- ...

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ELISpot 400x more sensitive than ELISA! Detection & Visualisation at the Single-Cell Level Explore ELISpot ...

Co-stimulatory and Co-inhibitory Molecules in Adaptive Immunity The adaptive immune system is in part regulated by a vast array of co-stim ...

COVID-19 Nasal Swab Test Nasal/Nasopharyngeal Swabs for Viral Sample Collection The developme ...

Create your own custom multiplex assay with over 400 analytes to choose from! At Assay Genie we can develop custom assays to meet your research needs within 10 days! To find out more infor ...

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Cell-Based ELISA Kits No More Western Blots! Over 1,600 Cell-Based ELISA kits to measure the relative levels of intracellular and phosphorylat ...

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Adipocytokines or adipokines are bioactive molecules that are produced by adipose tissue. They comprise cytokines, chemokines coagulation factors and factors involved ...

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