9496 results for 'Apolipoprotein A-I/ApoA1'

When PhDs and Post-Docs start in new lab they have the best intentions to keep their lab books up to date with notes, new research methods, data, and protocol information. These best efforts u ...

Mononuclear phagocytes, essential in immunity and homeostasis, perform diverse roles from phagocytosis to tissue repair, influencing health and disease. Key Takeaways: Mononuclear ...

Esophageal cancer is a type of cancer that affects the esophagus, which is the tube that carries food and liquids from your mouth to your stomach. Esophageal cancer can cause many d ...

Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early unders ...

By Charlotte O’Donnell PhD Cancer Carcinogenesis is a multi-step process that develops through epigenetic changes an ...

Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...

One of the greatest challenges in cancer therapy is how tumors evade immune detection. Among the mechanisms cancer cells exploit, the CD47 pathway has emerged as a major player in helpin ...

Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer, representing about 85% of all lung cancer cases. NSCLC includes several subtypes, with distinct biological c ...

Immune evasion is one of the hallmarks of cancer, where tumor cells employ various strategies to suppress immune responses and prevent destruction by the body’s defense systems. CD200, a ...

What is Gut Inflammation? The gut, or gastrointestinal (GI) tract is a long tube that starts from the mouth and extends to the anus. It includes various organs suc ...

Cell Culture · ProtocolsPassaging Hybridoma Cells: A Detailed GuideHybridomas are productive but temperamental. They grow in suspension, are sensitive to shear and to overgrowth, and — the problem th ...

Explore the complexities of Interleukin-10 (IL-10) signaling and regulation, a crucial aspect in immune response modulation and its dual roles in cancer development and therapy. Key Takeaways ...

Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis (IPF) is a chronic, irreversible and ultimately fatal disease characterized by pro ...

Key Facts About SacituzumabWhat is Sacituzumab?Sacituzumab is an antibody-drug conjugate (ADC) that targets the tumor-associated antigen Trop-2, used to treat various cancers, including ...

Harnessing the immune system to fight cancer has become a pivotal strategy in modern oncology. A key component in this fight is CD27, a receptor that plays a crucial role in T-cell activ ...

PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a ...

Quick Facts About LirilumabWhat is Lirilumab?Lirilumab is an anti-KIR monoclonal antibody designed to enhance natural killer (NK) cell activity by blocking killer-cell immunoglobulin-li ...

Cancer immunotherapy has revolutionized treatment options, offering strategies to harness the immune system to target and destroy tumors. One emerging area of interest is the use of OX40 ...

In the intricate landscape of cellular communication, lies a sophisticated ...

Immunology · Flow CytometryT Cell Immunophenotyping: Markers, Subsets and Panel DesignImmunophenotyping identifies cell populations by the proteins on their surface. For T cells that means resolving ...

Quick Facts About Patritumab DeruxtecanWhat is Patritumab Deruxtecan?Patritumab Deruxtecan (HER3-DXd) is an investigational antibody-drug conjugate (ADC) targeting HER3, a receptor impl ...

A neuron is a cell that processes and transmits information through electrical and chemical signals. There are trillions of them in the human brain, which is able to carry out so many comple ...

ELISA Genie is delighted to announce the date of our next Cancer Research Club which will be taking place on the 31st of March at TTMI, Trinity College Dublin. This event will foc ...

#ag-case-post a:hover{color:#0b6ea3 !important;} #ag-case-post .ag-pill:hover{background:#1f9ed6 !important;color:#ffffff !important;} #ag-case-post .ag-prod:hover{box-shadow:0 8px 22px rgba(2 ...

TIGIT (T cell immunoreceptor with Ig and ITIM domains) has emerged as a promising target in cancer immunotherapy and the treatment of autoimmune diseases. As a checkpoint receptor, TIGIT ...

IntroductionCancer cells have developed sophisticated mechanisms to evade the immune system, particularly through the inhibition of T-cell responses. One such mechanism involves the prog ...

The IgA test, also known as immunoglobulin A test, is a diagnostic tool used to measure the levels of IgA antibodies in the blood. Immunoglobulin A (IgA) is a type of antibody that plays a cru ...

Cancer cells are adept at avoiding destruction by the immune system, often exploiting specific pathways to escape detection and elimination. One of these key mechanisms involves the SIRP ...

What is the Coronavirus Spike Protein? COVID-19, the newest coronavirus to gain international attention, is caused by severe acute respirato ...

Embryonic induced pluripotent stem cells (iPSCs) hold immense potential in the field of regenerative medicine due to their ability to differentiate into various cell types. Understanding the diff ...

Structure, Function, and Detection Assays for COVID-2019 Background The global spread of the novel co ...

Autophagy, a fundamental cellular process, is crucial for maintaining cellular homeostasis and responding to various stressors. This self-eating mechanism involves the degradation and recycling o ...

The CD28 molecule plays a crucial role in amplifying T cell activation, which is critical for mounting effective immune responses against tumors. By engaging with co-stimulatory molecule ...

T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to e ...

Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target f ...

window.SHOGUN_IMAGE_V2_ELEMENTS = window.SHOGUN_IMAGE_V2_ELEMENTS || new Array(); window.SHOGUN_IMAGE_V2_ELEMENTS.push({ uuid: 's-19118a5d-7dea-4fc9-8267-6237960845ca' }) The T ...

Katherine Edwards, PhD Student, Queen’s University Belfast Cytokines play a vital role in immune responses enabling cross-talk between different cell types ...

Introduction to TLR4 and Cancer Toll-like receptor 4 (TLR4) is a key component of the innate immune system, primarily responsible for detecting infections and initiating inflammator ...

Schwann cells are cells that play a vital role in nerve function. They are responsible for myelinating axons and helping to ensure the transmission of electrical signals between neurons. Schwann ...

Laura Menke PhD candidate, Queen Mary University of London Inflammation vs. Resolution Atherothrombosis is the leading cause of death worldwide ...

Toll-Like Receptors The innate immune response has come under the spotlight in recent years due to its central role in propagating the pathoge ...

Enzyme-Linked Immunosorbent Assay (ELISA) is a powerful analytical biochemistry assay that utilizes antibodies and color change to identify a substance. It is widely used in the field of immunolo ...

In Vivo Methods · ProtocolsMouse Injection Guide: Intraperitoneal, Subcutaneous, Intramuscular & Intravenous RoutesRoute choice and injection technique determine how much of a dose actually reach ...

Complete T Helper Cell Guide: Th1, Th2, Th17 & Functions - Your Ultimate Resource from Assay GenieIn this guide, we will explore the differences between TH1 and TH2 cells, their cruc ...

کیت غربالگری مهار کننده آنزیم آنژیوتانسین II (ACE2) آنزیم تبدیل آنژیوتانسین II(ACE2, EC 3.4.17.23)، کربوکسی پپتیداز بخشی از س ...

Announcement · Powered by Assay GenieIntroducing BioSymposia: The Gathering Place for ScienceWe’re excited to announce the launch of BioSymposia, our new sister platform and a free home for sc ...

Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surroundin ...

Glutamate receptors are pivotal in mediating excitatory neurotransmission in the central nervous system (CNS), playing crucial roles in synaptic transmission, plasticity, learning, and memory. Th ...

As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis related d ...

Nuclear Factor Erythroid 2–Related Factor 2 (NRF2) orchestrates a principal defense mechanism against oxidative stress and plays a pivotal role in inflammation and disease pathogenesis. This arti ...

Biochemistry · Cell SignallingPhosphorylation: Types, ATP Synthesis and Cell SignallingAdding a phosphate group is how cells both store energy and switch proteins on and off. The same chemistry under ...

What is a Macrophage? Macrophages are indeed a type of phagocyte, responsible for engulfing and destroying foreign particles and cellular debris. They are larger cells with more cytoplasm a ...

Ubiquitin is a small, highly conserved protein found in eukaryotic cells that plays a crucial role in regulating various cellular processes. The process of ubiquitination involves the covalent at ...

Small molecule inhibitors represent a significant advancement in the field of therapeutic interventions, offering a versatile approach to treating a myriad of diseases, including cancer, viral in ...

In the realm of immunology, CXCL chemokines emerge as fascinating conductors. These small proteins, marked by their CXC motif, wield considerable influence over our immune responses and a r ...

What is preeclampsia? According to the World Health Organization (WHO), one in ten pregnant women is affected by hypertensive disorders, and preeclampsia ...

BRIEF HISTORY OF THE “GREEN” EVOLUTION OF OXYGEN AND CARBON DIOXIDE WITHIN OUR ATMOSPHERE Million years ago carbon dioxide (CO2) levels used to be consid ...

In the realm of immunology, the terms "immunoglobulin" and "antibody" often find themselves used interchangeably, sparking confusion among those keen on understanding the immune system's fine det ...

In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germ ...

Gastroenterology · Barrier BiologyZonulin and Intestinal PermeabilityZonulin is the best-characterised endogenous regulator of intestinal tight junctions — the protein that opens the gut barrier on d ...

Unravel the complexities of bone resorption, a crucial biological process essential for skeletal health and calcium regulation, through the intricate roles of osteoclasts and osteoblasts. K ...

Time-Resolved Fluorescence (TRF) technology is a cutting-edge analytical technique that has revolutionized the fields of biochemistry, immunology, and molecular biology. By offering a refined app ...

The complex interplay between chemokines and cytokines is fundamental to the immune system's function, orchestrating the body's response to infection, inflammation, and injury. This detailed anal ...

The intricate process of stem cell differentiation and self-renewal is a cornerstone of developmental biology and regenerative medicine. At the heart of this complex regulatory mechanism are tran ...

Molecular Biology · ProtocolsTypical Workflow of CRISPR-Cas9 Genome EditingA CRISPR experiment is only as good as the steps around the cut. This guide walks the full workflow — designing and scoring ...

Melanoma is an aggressive type of skin cancer that originates in melanocytes, the cells responsible for producing melanin, which gives skin its color. Although it is less common than oth ...

Vascular Endothelial Growth Factor A (VEGFA) is a pivotal signaling protein involved in both vasculogenesis and angiogenesis, processes essential for the formation of blood vessels during embryon ...

SARS-CoV-2 Background COVID-19 is characterised by a series of biological markers. In some instances, these biomarkers can be used as potent ...

@import url('https://fonts.googleapis.com/css2?family=Poppins:wght@400;600;700;800&display=swap'); .agp{--blue:#0072bc;--blue-d:#00528c;--accent:#2ba9e0;--ink:#1f2a37;--muted:#5b6b7b;--line:#e3eaee; ...

Cell culture techniques are fundamental to biomedical research, providing crucial insights into cellular functions, drug discovery, and disease mechanisms. A critical step in cell culture is the ...

By Eleni Chrysostomou, PhD Candidate, NUIG Why do we need to know how the Nervous System develops and regenerates? The structure and function of ...

@import url('https://fonts.googleapis.com/css2?family=Poppins:wght@400;600;700;800&display=swap'); .agp{--blue:#0072bc;--blue-d:#00528c;--accent:#2ba9e0;--ink:#1f2a37;--muted:#5b6b7b;--line:#e3eaee; ...

Transforming Growth Factor-Beta (TGF-β) signaling pathway plays a pivotal role in orchestrating various cellular processes, ranging from embryonic development to tissue homeostasis and immun ...

What is a Plasma Membrane? The plasma membrane, also known as the cell membrane, is a vital component of all cells. It is a thin, semi-permeable barrier that separat ...

By Rachel Bleach, PhD Student, RCSI By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reporte ...

Pyroptosis is an immunogenic form of cell death, meaning that it triggers an immune response. This makes pyroptosis a potentially promising target for immunotherapies that aim to bo ...

The eukaryotic cell is a complex and dynamic system with distinct membrane-bound compartments known as organelles, each performing specialized functions essential for cellular survival. To better ...

At Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis! Key Takeaways: Apoptosis is a programmed cell death process, vital for tissu ...

by Ryan Wallis, PhD student, QMUL, Blizard Institute The microscopic world of cell biology was first explored by Robert Hooke in the 17th century and published in his work, Microgr ...

In the relentless fight against cancer, immunotherapy has emerged as a beacon of hope, harnessing the body's own defenses to combat malignant cells. Yet, predicting which patients will respond to th ...

@import url('https://fonts.googleapis.com/css2?family=Poppins:wght@400;600;700;800&display=swap'); .agp{--blue:#0072bc;--blue-d:#00528c;--accent:#2ba9e0;--ink:#1f2a37;--muted:#5b6b7b;--line:#e3eaee; ...

Adipocytokines or adipokines are bioactive molecules that are produced by adipose tissue. They comprise cytokines, chemokines coagulation factors and factors involved ...

:root { --ink: #0f1419; --ink-soft: #3a4350; --ink-mute: #6b7785; --line: #e4e7ec; --line-soft: #f0f2f5; --bg: #fafaf7; --paper: #ffffff; --accent: #002FE1; /* Assay Genie bra ...

:root { --ink: #0f1419; --ink-soft: #3a4350; --ink-mute: #6b7785; --line: #e4e7ec; --line-soft: #f0f2f5; --bg: #fafaf7; --paper: #ffffff; --accent: #002FE1; /* Assay Genie bra ...

Cell Viability, Cytotoxicity & Proliferation Assay Kits | Assay Genie /* Hide BigCommerce's default page title + breadcrumb wrapped around this content */ .page-heading,.page ...

Lipid Metabolism Assay Kits | Cholesterol, Fatty Acids & Bile Acids | Assay Genie /* Hide BigCommerce's default page title + breadcrumb wrapped around this content */ .page-h ...

Custom In Vivo Antibody Service | Assay Genie .page-content-body{border:none!important;} .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none !impor ...

Custom Protein & Peptide Service | Assay Genie .page-content-body{border:none!important;} .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none ! ...

Co-stimulatory and Co-inhibitory Molecules in Adaptive Immunity The adaptive immune system is in part regulated by a vast array of co-stim ...

Custom Protein & Peptide Service | Assay Genie .page-content-body{border:none!important;} .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none ! ...

Custom Protein & Peptide Service | Assay Genie .page-content-body{border:none!important;} .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none !impo ...

Custom ELISA Kit Development Service | Assay Genie .page-content-body{border:none!important;} .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none ! ...

Animal & Veterinary ELISA Kits | Mouse, Rat, Porcine & More | Assay Genie .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none !important; ...

Custom Antibody Production Service | Assay Genie .page-content-body{border:none!important;} .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none !im ...

TCA/Krebs Cycle Assays At Assay Genie we've developed a range of TCA assays for researchers to analyse key steps in the Krebs/TCA/Citric Acid cycle pathway. Different Products ...

Protocols & Assay Guides | ELISA, Multiplex, Western Blot | Assay Genie { "@context": "https://schema.org", "@graph": [ { "@type": "CollectionPage", "name": "Protocols & Assay ...

Molecular Biology Tools, PCR & Cloning Kits | Assay Genie .page-content-body{border:none!important;} .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { disp ...

IHC Antibodies | Validated Antibodies for Accurate IHC Staining | Assay Genie .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none !important; } ...

Flow Cytometry Antibodies | 16,900+ Conjugates & Panel Builder | Assay Genie .page-heading, .page-title, .breadcrumbs, .breadcrumb-list, nav.breadcrumbs { display: none !important; } .page-s ...

Ferroptosis Assay Kits | Lipid Peroxidation, Iron & Glutathione | Assay Genie /* Hide BigCommerce's default page title + breadcrumb wrapped around this content */ .page ...