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One Ligand, Two Receptors, Opposite Jobs: TNFR1 vs TNFR2(Post)
Blocking TNF cures rheumatoid arthritis in some patients and triggers demyelination in others. That is not a dosing problem, and it is not a patient-selection problem. It is the direct consequence of
Binding Is the Easy Part(Post)An antibody–drug conjugate is not a targeted drug. It is a delivery problem with an antibody bolted to the front of it. Binding is the easy part, and it is almost never the part that fails. What deci
Trained Immunity: How Your Innate Immune System Learns and Remembers(Post)For decades, immunologists believed that only adaptive immunity—the sophisticated system of T cells and B cells—could form lasting memories of past infections. The innate immune system, our body's fir
IHC Troubleshooting Guide - Mandarin(Page)免疫组织化学(IHC)故障排除指南(中文) | Assay Genie
Monocytes: An Overview (Post)Monocytes, as part of the innate immune system, act as the first line of defense against foreign invaders. One of their primary functions is phagocytosis, a crucial process in which they engulf
Bone Resorption: Process, Markers & Clinical Significance(Post)Unravel the complexities of bone resorption, a crucial biological process essential for skeletal health and calcium regulation, through the intricate roles of osteoclasts and osteoblasts. Ke
AID, Hypermutation and B-Cell Lymphoma(Page) Immunophenotyping by Flow Cytometry and Cell Type Markers(Post)Immunophenotyping by Flow Cytometry Immunophenotyping is a technique used in the field of immunology and cell biology to identify and classify cells based on the specific proteins o
Understanding CD16: A Comprehensive Overview(Post)CD16, also known as FcγRIII (Fc gamma receptor III), plays a crucial role in the immune system, serving as a receptor for the Fc region of immunoglobulin G (IgG). This receptor is a key player in
Navigating the Intricacies of Intracellular Flow Cytometry: Key Considerations(Post)In the evolving landscape of cellular biology, intracellular flow cytometry (ICFC) stands out as a powerful technique for analyzing the complexities within cells. This advanced method extends the
Melanoma: Understanding, Diagnosing, and Treating Skin Cancer(Post)Melanoma is an aggressive type of skin cancer that originates in melanocytes, the cells responsible for producing melanin, which gives skin its color. Although it is less common than othe
2025 Nobel Prize in Medicine: Regulatory T Cells and Peripheral Immune Tolerance(Post)The 2025 Nobel Prize in Physiology or Medicine has been awarded to a trio of scientists for their groundbreaking work on peripheral immune tolerance, a mechanism that prevents our immune system from a
Innate Immune System Explained: Step-by-Step Process & Key Concepts(Post)Immunology · Cell BiologyCells of the Innate Immune System: Types, Functions and MarkersThe innate immune system responds within minutes, without prior exposure, using cells that recognise conserved m
From Stem Cells To Neurons: A Cnidarian Approach(Post)By Eleni Chrysostomou, PhD Candidate, NUIG Why do we need to know how the Nervous System develops and regenerates? The structure and function of the n
Unlocking Cellular Adaptation: The HIF Enhancer Pathway and Its Implications in Hypoxia Response(Post)Hypoxia, or low oxygen levels, poses a significant challenge to cells, necessitating rapid and efficient adaptation mechanisms. The Hypoxia-Inducible Factor (HIF) pathway is a well-known regula
Horseshoe Crab Blood and Endotoxin Testing: A Comprehensive Guide(Post)Horseshoe crabs, often referred to as "living fossils," are invaluable to modern medicine due to their unique blue blood. This blood is the source of Limulus Amebocyte Lysate (LAL), a sub
CB6 Biosimilar: Targeting SARS-CoV-2 with Cost-Effective Monoclonal Antibody Therapy(Post)CB6, also known as Etesevimab, is a monoclonal antibody that targets the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. It neutralizes the virus by preventing it from bind
Research Universities in Ireland(Post)Since I am from Ireland I thought I would give as comprehensive view as possible for Research Universities in Ireland. By now you are probably considering looking for a PhD or PostDoc positi
A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer(Post)Mechanical forces are common in biological systems and dominate numerous perturbations that are relevant to human physiology and disease. Mechanobiology is a new field that evaluates the eff
Investigating orthohantavirus infections with proteomics(Post)Sarah Brun Bar-Yaacov PhD Candidate, University of Liverpool Orthohantaviruses are a group of segmented negative-sense RNA viruses maintained as asympto