10768 results for 'PLC-gamma 2'

The intricate process of mesenchymal stem cell (MSC) differentiation is a cornerstone of developmental biology and regenerative medicine. Mesenchymal stem cells, renowned for their self-renewal ca

Quick Facts About EmapalumabWhat is Emapalumab?Emapalumab is a fully human monoclonal antibody that neutralizes interferon-gamma (IFN-γ). It is the first FDA-approved therapy for primary

Cell Signalling · EnzymologyProtein Kinases: Function, Classification, Structure and InhibitorsProtein kinases transfer a phosphate group from ATP onto specific residues of target proteins, switching

Laura Menke PhD candidate, Queen Mary University of London Inflammation vs. Resolution Atherothrombosis is the leading cause of death worldwide

An antibody's variable domains decide what it binds. Its Fc decides what happens next — and that is not a detail of formulation, it is half the mechanism. Which Fcγ receptor the constant region engag

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor epidermal growth factor receptor (EGFR) which triggers ligand-induced d

Interleukin signaling is involved in a number of biological processes, including cell growth and differentiation, inflammation and immunity. Interleukins are glycoproteins which act on hema

What is a Macrophage? Macrophages are indeed a type of phagocyte, responsible for engulfing and destroying foreign particles and cellular debris. They are larger cells with more cytoplasm an

Ahmad Gazali PhD candidate, University of Eastern Finland Type 1 diabetes (T1D) is an autoimmune disease where the pancreatic β cells that produce insulin, a key hormone involved in t

CD25, a key molecule in immune regulation, is integral to the function of activated lymphocytes and regulatory T cells. It's central in mediating immune responses, with implications in autoimmune

Haematology · CoagulationBlood Coagulation Pathway: Factors, Cascade and DisordersThe coagulation cascade is usually taught as two pathways converging on a common one. That framework maps neatly onto

Immunology · Antigen PresentationDendritic Cells: Markers, Activation and SubtypesDendritic cells are the professional antigen-presenting cells that decide whether an immune response happens at all. T

Key Facts About EtigilimabWhat is Etigilimab?Etigilimab is an anti-TIGIT monoclonal antibody being studied for its potential role in cancer immunotherapy.What role does Etigilimab play i

Immunology · Antibody BiologyAntibody Light Chains, Heavy Chains, Constant Regions & Tumour-Associated AntigensAn antibody’s specificity comes from its variable domains and its biological effect comes

What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to investigating the intricate and bidirectional interactions between the c

Key Points Non-alcoholic fatty liver disease (NAFLD) refe

Cell Signalling · Receptor BiologyGPCRs (G Protein-Coupled Receptors): A Complete GuideG protein-coupled receptors are the largest family of cell-surface receptors in the human genome and the ta

A New Dawn in Cancer Treatment: Reprogramming the Immune System's Own Soldiers For decades, the fight against cancer has been a relentless battle of attrition, with treatments like chemotherapy and r

The recent advances in cancer immunotherapy have brought new opportunities to harness the body’s immune system against tumors. Among these advancements is the targeting of immune checkpoi