EGF Family

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor epidermal growth factor receptor (EGFR) which triggers ligand-induced dimerization which activates the intrinsic protein-tyrosine kinase activity of EGFR. This in turn initiates a signal transduction cascade that results in various biochemical changes within the cell being targeted by EGF. This ultimately leads to DNA synthesis and cell proliferation. Members of this protein family are all similar due to their shared structural and functional characteristics.

Each member of the EGF family have at least one common structural motif, the EGF domain, which is characterised by six conserved cysteine residues forming three disulphide bonds. Family members include EGF, Betacellulin, Amphiregulin, Epiregulin and others. ELISA Genie offers an extensive range of ELISA kits that measure the activity of various members of the EGF Family.


23rd May 2022 BigCommerce

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