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Two Asthma Drugs, Opposite Eosinophil Counts, Both Working(Post)
Two asthma biologics have opposite effects on the blood eosinophil count, and both of them work. Mepolizumab empties the eosinophil compartment; dupilumab can transiently raise it. If that seems cont
The Gut Microbiome and Autoimmune Diseases: How Gut Bacteria Influence Immune Response(Post)What are Autoimmune Diseases? Autoimmune diseases are a diverse group of disorders where the immune system mistakenly attacks the body's own cells, tissues, and organs
Immuno-Biomaterial Development | Assay Genie(Post)Background I am a 3rd year PhD student in Trinity College Dublin and my project is very much an interdisciplinary one. I’m very lucky to get to work between two great labs, Dr. Aisling Dunn
Mesenchymal Stem Cell Differentiation Pathways: Unraveling Lineage-Specific Markers(Post)The intricate process of mesenchymal stem cell (MSC) differentiation is a cornerstone of developmental biology and regenerative medicine. Mesenchymal stem cells, renowned for their self-renewal ca
Cytokine Neutralisation In Vivo: Targets, Signals and Antibodies(Post)Almost any inflammatory phenotype in a mouse can be assigned to a cytokine by taking that cytokine away. Neutralisation is the most direct causal test immunology has: inject a functional-grade antibo
Disease and Pathways Tools(Page)Disease & Pathway Tools | ELISA Kits, Antibodies & Assays by Research Area | Assay Genie
Navigating Cell Culture Supplements: Fetal Bovine Serum vs. Horse Serum in Biomedical Research(Post)The choice of appropriate cell culture supplements emerges as a crucial factor in ensuring the efficacy and consistency of experimental results. Among the various options available, two commonl
Mycoplasma Detection Kit Troubleshooting: The Importance of Cell Confluence(Post)Quick answer A researcher's samples read negative at the standard 1-hour incubation on the MycoGenie Rapid Mycoplasma Detection Kit (MORV0011), but many turned positive after 2 hours.
CD11b: Macrophages and Microglia Marker(Post)The immune system plays a critical role in defending the body against pathogens and maintaining tissue homeostasis. Within the intricate network of immune cells, CD11b, also known as integ
Cancer & Tumour Suppressors – Mini Review(Post)Cancer DevelopmentCancer is a group of diseases that involves abnormal cell growth resulting in malignant tumours/ malignant neoplasms. Cancer is a leading cause of morbidity, with 14 million ne
Transduction vs Transfection: Understanding Gene Delivery Techniques(Post)Techniques · Gene DeliveryTransduction vs Transfection: Understanding Gene Delivery TechniquesTransduction and transfection are the two main routes for introducing genetic material into cells. Transdu
Exploring Organelle Markers: Illuminating the Cellular Landscape(Post)The eukaryotic cell is a complex and dynamic system with distinct membrane-bound compartments known as organelles, each performing specialized functions essential for cellular survival. To better
Myeloid Lineage: Pioneers of Immune Cell Production(Post)Immunology · HaematopoiesisMyeloid Lineage: Pioneers of Immune Cell DevelopmentThe myeloid lineage is one of the two great branches of haematopoiesis, generating the innate immune and blood cells — mo
HERV-K group of endogenous retroviruses and cancer(Post)In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germl
JAK-STAT Signalling and Cytokines: The What, How, and Why(Post)Cell Signalling · CytokinesJAK-STAT Signalling: Mechanism, Regulation and InhibitorsJAK-STAT is the shortest route from a cytokine outside the cell to a change in gene transcription — receptor engagem
Ovarian Cancer: Symptoms, Causes, Diagnosis and Treatment(Post)Ovarian cancer is the fourth most common cancer in women. Ovarian cancer is when the normal cells in the ovary change and grow to form a tumour. Because the ovaries are located deep
Dupilumab: Transforming Immunotherapy and Skin Disease Management(Post)What You Need to Know About DupilumabWhat is Dupilumab?Dupilumab is a fully human monoclonal antibody designed to treat various chronic inflammatory diseases by inhibiting key cytokines
Influenza Hemagglutinin (HA) Subtypes and Flu Virus Strains: What You Need to Know(Post)The flu is a highly contagious virus that affects the respiratory system. It can cause fever, muscle aches, and coughing. In some cases, it can lead to more serious health complicati
An Introduction into EV Markers(Post)Extracellular Vesicles
Hepatocyte growth factor (HGF) (Post)What is Hepatocyte Growth Factor? Hepatocyte growth factor (HGF) is a cytokine that is mainly produced by the liver. HGF is a pleiotrophic cytokine that regulates cell growth, motilit