10178 results for 'Fatty Acid Synthase/FASN'

Understanding Beta-Oxidation: A Comprehensive Overview Fatty acids provide a highly efficient energy storage mechanism, delivering more energy per gram than common carbohydrates like glu ...

Key Points Non-alcoholic fatty liver disease (NAF ...

Amino acids are the fundamental units of proteins, playing critical roles in virtually every biological process. Composed of a central carbon atom bonded to an amino group (-NH₂), a carb ...

What is Immunometabolism? Immunometabolism is an exponentially growing, multi-disciplinary field of research aiming at deciphering the dynamic cellular and mol ...

Fenofibrate, also known as FEN, is a drug that is used to lower cholesterol levels. It works by blocking the absorption of dietary cholesterol in the small intestine and therefore, re ...

Laura Menke PhD candidate, Queen Mary University of London Inflammation vs. Resolution Atherothrombosis is the leading cause of death worldwide ...

Discover the intricacies of cellular respiration, a critical process for energy production in cells, encompassing aerobic and anaerobic pathways and their molecular mechanisms Key Takeaway ...

Throughout my graduate and postgraduate studies I have been really intrigued and fascinated by the mitochondria, the organelle that keeps all of us running everyday! The more I learn about ...

Exploring the Role of Gut Fungi in Neurodegenerative Diseases Neurodegenerative diseases, including dementia, represent a significant challenge to global health. Recent research has begun to uncove ...

Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surroundin ...

Acetylation, a chemical process characterized by the addition of an acetyl functional group to a molecule, stands as a cornerstone in both biochemical and biological landscapes. Its significan ...

By Anusha Senevirante, Post-Doctoral researcher, Imperial College London With non-communicable diseases (or NCDs, which include heart disease, diabetes, c ...

Acute pancreatitis (AP) is a condition in which activated enzymes and inflammatory mediators released from the pancreas cause damage to the pancreas and surrounding tissues. AP is fur ...

Oxidative Stress Definition Oxidative stress is a condition that results when the body produces or consumes more reactive oxygen species (ROS) than it can neutrali ...

What is Gut Inflammation? The gut, or gastrointestinal (GI) tract is a long tube that starts from the mouth and extends to the anus. It includes various organs suc ...

Introduction Phosphorylation is a fundamental biochemical process that plays a crucial role in various cellular functions. It involves the addition of a phosphate group to a molecule, typ ...

The gut-brain axis, a dynamic bi-directional communication system linking the gastrointestinal (GI) tract with the central nervous system (CNS), has emerged as a focal point in scie ...

The Mitogen-Activated Protein Kinase (MAPK) pathway is a pivotal signaling cascade that plays a crucial role in mediating cellular responses to various external stimuli. This pathway is intricate ...

Microglia Astrocytes Oligodendrocytes Glial ...

Delving into the world of Lactobacilli, this piece explores their structural intricacies, metabolic functions, and the pivotal role they play in human health. These bacteria, key components in ...

Transfection protocols play a crucial role in the realm of molecular biology and genetic research, enabling the introduction of foreign nucleic acids into living cells. This innovat ...

By Shane Houston, PhD Candidate Queen’s University Belfast Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health ...

Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Pancreatic can ...

If you've ever had a urinary tract infection, you know all about bacteria. These tiny organisms can invade your body and cause all sorts of problems. But what you may not know is th ...

Hepatocellular carcinoma (HCC) is one of the most frequently occurring cancers and there are 630,000 new cases diagnosed every year worldwide (De Minicis et al. 2013). HCC develops frequently f ...

Deprotonation is a fundamental chemical process that plays a crucial role in various aspects of chemistry, ranging from organic synthesis to biochemistry. It involves the removal of a proton ( ...

The prevalence of obesity and its associated metabolic disorders has risen dramatically in recent decades, presenting a significant global health challenge. Adipose tissue, once considered mer ...

Major Histocompatibility Complex (MHC) molecules are essential for immune recognition and response. They are specialized glycoproteins that present antigens to T cells, allowing the immu ...

In the realm of molecular biology and genetic engineering, the ability to deliver genetic material into cells is fundamental for various research and therapeutic purposes. Two common methods e ...

In the complex world of biochemical processes, enzymes play a crucial role in catalyzing various reactions necessary for life. Among these enzymes, proteases and peptidases are fundamental pla ...

ST2, a member of the IL-1R Subfamily ST2 is a member of the IL-1R subfamily and was identified in 1989 [1]. The ST2 gene is located on chromos ...

Myrna Hurtado, PhD Student, University of North Texas Health Science Center Advancements in modern medicine have resulted in significantly prolonging and ...

What are Toll Like Receptors? Toll-like receptors (TLRs) are a class of proteins that play a crucial role in the immune system's defense against microbial invaders ...

Fluorescence Resonance Energy Transfer (FRET) assays represent a pivotal technique in the molecular and cellular biology fields, enabling the examination of protein interactions, nucleic acid str ...

Dr. Melissa Conroy, TTMI I am an immunologist and senior research fellow in the Cancer Immunology and Immunotherapy Group, Department of Surgery at Trinit ...

The mammalian target of rapamycin (mTOR) signaling pathway is a crucial regulator of cell growth and metabolism, responding to environmental cues and cellular energy status. This pathway's signif ...

Oesophageal Adenocarcinoma is on the rise globally affecting more than 450,000 people worldwide (Pennathur, Gibson et al. 2013). Once diagnosed overall 5-year survival ranges from 15 % to ...

Cancer Metabolism is the mechanism by which cancer cells make energy in order for them to grow and spread. Even in the presence of oxygen, cancer cells increase glucose uptake and produce lactate ...

Pyruvate dehydrogenase is a complex enzyme involved in the conversion of pyruvate, a product of glycolysis, into acetyl-CoA, a crucial molecule in energy production and intermediary ...

Cell Signalling Cell signalling pathways have an important role in integrating a plethora of extracellular and intracellular signals to produce a controlled optimal ...

Histamine, a biogenic amine, plays a crucial role in various physiological processes, including immune responses, gastric acid secretion, and neurotransmission. Central to the action of histamine ...

Testing for COVID-19 Since the start of the COVID-19 pandemic, the World Health Organisation have emphasised the crucial impor ...

Phosphorothioate is a chemical modification commonly used in oligonucleotide-based therapies to enhance the stability and efficacy of therapeutic nucleic acids. In this modification, one ...

What is a vaccine? A vaccine is a pharmacological product that gives the recieving patient's immune system a chance to learn how to fight infection with decreased risk of illness. Vacc ...

Mouse monoclonal antibodies are a valuable tool in the biomedical field. They can be used for a variety of applications, from research to clinical diagnostics. In this blog post, we ...

What is CD52? Cluster Of Differentiation 52 (CD52) is a highly expressed membrane glycoprotein which is present on the surface of immune cel ...

The use of M2 Supplement in organoid culture has revolutionized the way researchers cultivate and maintain these three-dimensional (3D) cellular models. Organoids—self-organizing cell cl ...

Imagine a highly trained soldier, elite and effective, sent to the front lines of a relentless war. Day after day, they fight without rest, their supplies dwindle, and the enemy never stops coming. E ...

In the realm of molecular biology and biochemistry, gel electrophoresis stands as a cornerstone technique for the separation and analysis of macromolecules such as DNA, RNA, and proteins. Central ...

Schwann cells are cells that play a vital role in nerve function. They are responsible for myelinating axons and helping to ensure the transmission of electrical signals between neurons. Schwann ...

Glycolysis is a fundamental metabolic pathway that involves the breakdown of glucose to produce energy. This process can occur through two main pathways: aerobic and anaerobic glycolysis. Both p ...

Explore the world of astrocytes, crucial star-shaped cells in the brain, and understand how specific markers help study their roles in neural health and disorders. Key Takeaways: As ...

Delve into the pivotal role of Neurofilament Light chain (NEFL) in neuron structure and its emerging importance as a biomarker for various neurodegenerative diseases, offering insights into di ...

What is Necrosis? Necrosis is a pathological process characterized by the death of cells or tissues within a living organism. It occurs as a result of various factors, including injury, inf ...

Why do powerful cancer immunotherapies work wonders for some patients but fail for others? The answer may lie not just in the cancer cells themselves, but in the energy levels of our own immune warri ...

Kinases, key enzymes in cellular signaling, phosphorylate proteins to regulate crucial processes, and their modulation has significant implications in disease treatment. Key Takeaways: K ...

What are MHC Class I molecules? The MHC class I is a glycoprotein that is expressed on all nucleated cells of the human body. MHC class I are important in disease defense against viruses, b ...

Exploring DNA's essence, this guide illuminates its structure, function, and purification techniques, essential in fields like medicine and biotechnology. Key Takeaways: DNA's Struc ...

In the realm of biomedical imaging, the quest for precision and clarity drives researchers to explore innovative technologies. One such breakthrough is the Cy3 wavelength, a powerful tool revo ...

RNA interference (RNAi), also referred to as Post-Transcriptional Gene Silencing (PTGS), is the process by which RNA molecules silence genes in response to double-stranded RNA. RNA interference ( ...

Ionotropic glutamate receptors (iGluRs) are pivotal in the fast excitatory synaptic transmission in the mammalian central nervous system (CNS). These receptors are not only crucial for normal bra ...

Platinum based cancer drugs Despite nearly 50% of all anti-cancer treatments being platinum-based, there is an urgent need to develop novel therapeutics ...

Structure, Function, and Detection Assays for COVID-2019 Background The global spread of the novel co ...

The complex interplay between chemokines and cytokines is fundamental to the immune system's function, orchestrating the body's response to infection, inflammation, and injury. This detailed anal ...

RIG-I: Antiviral Properties in COVID-19 (SARS-CoV-2) Infection Key Points RIG-I is a cytosolic RNA ...

Mycoprotein is an alternative source of protein that can be used in place of meat. It is made from a fungi called Fusarium venenatum, and is consumed by vegetarians and vegans as a meat su ...

Agata Miezaniec PhD Candidate, University of Nottingham, UK Epigenetics and the link to DNA Methylation The term ‘Epigene ...

The myelin sheath is an insulating layer around nerve cells. It is made up of a substance called myelin, which is produced by special cells called oligodendrocytes. Myelin protects the nerve cell ...

By Ciara Coleman PhD General Introduction Coeliac Disease (CD) is defined as a common, chronic inflammatory di ...

What is Hepatocyte Growth Factor? Hepatocyte growth factor (HGF) is a cytokine that is mainly produced by the liver. HGF is a pleiotrophic cytokine that regulates cell growth, motili ...

Esophageal cancer is a type of cancer that affects the esophagus, which is the tube that carries food and liquids from your mouth to your stomach. Esophageal cancer can cause many d ...

RIPA (Radio Immuno Precipitation Assay) buffer is mostly used when carrying out a western blot or immunoprecipatation assay. A RIPA buffer is used in order to lyse cells and extract protein fr ...

What is Cystic Fibrosis? Cystic fibrosis (CF) is a genetic disorder that impairs the body's ability to produce sweat and thick mucus. CF causes mucus to build up in ...

In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germ ...

IQGAP1: IQ-motif containing GTPase-activating-like protein-1 reviewIQ motif-containing GTPase-activating-like protein-1 (IQGAP1) is a 190 KDa protein that belongs to a conserved family of s ...

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TCA/Krebs Cycle Assays At Assay Genie we've developed a range of TCA assays for researchers to analyse key steps in the Krebs/TCA/Citric Acid cycle pathway. Different Products ...

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Plant & Environmental Stress Assays Explore our range of assays to measure reactive oxygen species, proline, secondary metabolites & more in plant tissues.

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Brochures & FlyersFind the information you needExplore Assay Genie's collection of scientific brochures and product flyers featuring our ELISA kits, antibodies, proteins, and custom ...

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Product CitationsMore than 1,000 cited products in scientific journalsWe're not just any scientific company; our products have made waves in the scientific community. From groundbreakin ...

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Knock Out Validated Antibodies Highly specific antibodies for consistent results! Explore KO Antibodies ...

Glycolysis & Carbohydrates Assays At Assay Genie we've developed a range of Glycolysis & Carbohydrates assays for researchers to analyse key indicators in the glycolysis pathwa ...

Epigenetic Antibodies Epigenteic Antibodies Organised by Epigenetic Modifications! window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Arr ...

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What is IHC? Immunohistochemistry (IHC) is a valuable tool used for the identification of specific antigens within embedded tissue prepara ...

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Oxidative Stress Assays Simple & Sensitive Assays to Investigate Oxidative Stress! ...

Transcription Factor Assays Detect Transcription Factors via indirect ELISA methods! Detect transcription factors or study transcription fact ...

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COVID-19 Throat Swab Test Throat/Oropharyngeal Swabs for Viral Sample Collection The development of diagnostic tests for COVID- ...

1-Step TUNEL Kits Unique 1-Step Non-Toxic Dewaxing Step for Late Stage Apoptosis Detection Explore TUNEL Assays ...