null

10536 results for 'caspases-3'

Did you mean: cascad 3 Refine Search
    Cleaved Caspase-3 and Apoptosis(Post)

    Delve into the role of Cleaved Caspase-3 in programmed cell death and its implications in disease pathologies, unraveling its regulatory mechanisms and potential as a therapeutic target.

    Apoptosis Caspase Pathways: A Closer Look at Cellular Suicide(Post)

    Apoptosis, or programmed cell death, is a fundamental process that plays a critical role in the development and maintenance of healthy tissues. Central to this process are caspases, a family of c ...

    Key Players in T Cell Regulation: Lag-3, Tim-3, and TIGIT(Post)

    Understanding Lag-3, Tim-3, and TIGIT: Key Players in T Cell RegulationThe immune system's ability to regulate T cell responses is crucial for maintaining homeostasis and combating diseases such as c ...

    TIM-3/Gal-9 Pathway in Antiparasitic Immunity(Post)

    Exploring the Role of TIM-3/Gal-9 in Antiparasitic ImmunityIntroductionThe immune system is a complex network of cells and molecules that work together to defend the body against pathogens, including ...

    LAG-3: Key Regulator of T Cell Immunity(Post)

    Exploring LAG-3: A Key Regulator in T Cell ImmunityLAG-3 (Lymphocyte Activation Gene-3) is an inhibitory receptor that plays a crucial role in modulating T cell activation and effector functions. Thi ...

    Apoptosis Unveiled: Your Complete Guide to Intrinsic & Extrinsic Pathways(Post)

    Apoptosis Unveiled: Your Complete Guide to Intrinsic & Extrinsic PathwaysAt Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis!K ...

    Cell Death Pathways: Intrinsic vs Extrinsic Apoptosis Guide(Post)

    At Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis! Key Takeaways: Apoptosis is a programmed cell death process, vital for tissu ...

    Mitotic Catastrophe Review(Post)

    Delving into the intricate world of Mitotic Catastrophe, this blog unveils its critical role in cell division and cancer therapy, offering insights into its mechanisms and potential treatments ...

    Pyroptosis: A Promising Target for Immunotherapy(Post)

    Pyroptosis is an immunogenic form of cell death, meaning that it triggers an immune response. This makes pyroptosis a potentially promising target for immunotherapies that aim to bo ...

    A Comprehensive Overview of Cell Death(Post)

    Cell death is an essential aspect of cellular biology that plays a crucial role in development, homeostasis, and disease. In this blog, we try to focus on mechanisms and various typ ...

    ​TNF alpha & Inflammation(Post)

    Delving into TNF alpha's critical role in inflammation and its therapeutic targeting. Key Takeaways: TNF alpha is a crucial cytokine in inflammation and apoptosis. Its structure facilita ...

    IL-1 Family Signaling: Unraveling the Molecular Orchestra of Immune Regulation(Post)

    The Interleukin-1 (IL-1) family represents a crucial group of signaling molecules that play a pivotal role in regulating the immune system and inflammatory responses. Comprising 11 members, in ...

    Inflammasome Activation Pathways: A Comprehensive Overview(Post)

    Inflammasomes are complex intracellular structures that play a pivotal role in the immune response by detecting pathogenic microorganisms and sterile stressors. Their activation is a critical ste ...

    3 Reasons to Publish in Open Access Journals(Post)

    Over the past few years momentum has gained in the scientific publishing community for researchers to publish their data in open access scientific journals. Open access to published research o ...

    Relatlimab: Unlocking the Potential of LAG-3 Inhibition in Cancer Research(Post)

    Quick Facts About RelatlimabWhat is Relatlimab?Relatlimab is a monoclonal antibody that targets LAG-3 (Lymphocyte Activation Gene-3), a key immune checkpoint involved in T-cell regulati ...

    LAG-3: Revitalizing T Cells in Exhaustion for Combination Therapies(Post)

    Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target f ...

    ST2 and IL33(Post)

    ST2, a member of the IL-1R Subfamily ST2 is a member of the IL-1R subfamily and was identified in 1989 [1]. The ST2 gene is located on chromos ...

    Nod-Like Receptor Signaling Pathway: A Keystone in Innate Immunity(Post)

    The innate immune system, a primary line of defense against pathogens, comprises various cellular and molecular mechanisms. Among these, the Nod-like Receptor (NLR) signaling pathways play a crit ...

    Cobolimab: Unveiling TIM-3’s Role in Cancer Immunotherapy(Post)

    Quick Facts About CobolimabWhat is Cobolimab?Cobolimab is a monoclonal antibody that targets TIM-3, a checkpoint protein involved in immune regulation, especially in cancer and autoimmu ...

    NLRP3 Inflammasome & Cytokine Secretion(Post)

    Nod-like receptors Nod like receptors (NLRs) are a versatile family of relatively recently discovered intracellular receptors which have a b ...

    TIM-3: Targeting T Cell Exhaustion for Better Immunotherapy Outcomes(Post)

    T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to e ...

    TUNEL staining : The method of choice for measuring cell death(Post)

    TUNEL Staining : The method of choice for measuring cell death In this article we will discuss everything you need to know about the TUNEL staining assay. We'll start by explaining wha ...

    How do antibodies work?(Post)

    Antibodies are a special class of Y shaped proteins that help guard your body from invading viruses and bacteria. They do this by either neutralizing the dangerous substance ...

    The role of IL-18 in health and disease(Post)

    Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...

    PCR Detection of COVID-19 (SARS-CoV-2)(Post)

    PCR Detection of COVID-19 (SARS-CoV-2) Contents Background Assay Information Sample Types   & ...

    What are MHC Class I and II molecules?(Post)

    What are MHC Class I molecules? The MHC class I is a glycoprotein that is expressed on all nucleated cells of the human body. MHC class I are important in disease defense against viruses, b ...

    Innate Viral Immunity & RIG-I in COVID-19(Post)

    RIG-I: Antiviral Properties in COVID-19 (SARS-CoV-2) Infection Key Points RIG-I is a cytosolic RNA ...

    How Furin and ACE2 Interact with the Spike on SARS-CoV-2(Post)

    What is the Coronavirus Spike Protein? COVID-19, the newest coronavirus to gain international attention, is caused by severe acute respirato ...

    Physiological and Pathological functions of IL-36(Post)

    By Charlotte O'Donnell PhD Similar to IL-33, IL-36R ligands are involved in maintaining intestinal homeostasis. Analogous to IL-33, d is local ...

    The IL-36 Subfamily | Expression, Function & Regulation(Post)

    By Charlotte O'Donnell PhD The genes of the IL-36 family members are located in a cluster on chromosome 2 [1]. All three activating ligands, IL-36α, IL-36β ...

    Tigatuzumab: Advancing Cancer Research with Targeted Therapies(Post)

    Quick Facts About TigatuzumabWhat is Tigatuzumab?Tigatuzumab is a monoclonal antibody that targets the death receptor 5 (DR5) pathway, inducing apoptosis in cancer cells.What is the mec ...

    Cyclophosphamide Side Effects(Post)

    Ovarian cancer is a set of malignancies that start in the ovaries, as well as adjacent portions of the fallopian tubes and peritoneum. Women have two ovaries, one on each side of the ...

    Understanding the Bcl-2 Pathway in Cancer Therapy(Post)

    Understanding the Bcl-2 Pathway: Implications for Cancer Therapy The Bcl-2 family of proteins plays a pivotal role in regulating apoptosis, a crucial process for maintaining cellula ...

    HERV-K group of endogenous retroviruses and cancer(Post)

    In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germ ...

    Liposomal nanosilver encapsulation for cytotoxic assays(Post)

    Nanosilver is the most commercialised nanoparticle routinely used for its antibacterial purposes in food preservation, cosmetic and health products such as medical devices and wound treatme ...

    Non-Alcoholic Fatty Liver Disease (NAFLD) - Biomarkers(Post)

    Key Points Non-alcoholic fatty liver disease (NAF ...

    An Introduction into EV Markers(Post)

    Extracellular Vesicles ...

    Ferroptosis: A New Frontier in Cancer Therapy(Post)

    For decades, the primary strategy in cancer treatment has been to trigger apoptosis, a form of programmed cell death, in malignant cells. However, many cancers develop resistance to apoptosis-induci ...

    Sensing Danger: The Biology of TLR-Mediated Inflammation(Post)

    By Eoin Mac Réamoinn Toll-like receptors (TLRs) are renowned for their fundamental roles in innate sensing and initiating inflammatory responses. TLR ...

    COVID-19 15分のRAPID POCテスト(Post)

    COVID-19 15分のRAPID POCテスト 詳細については、hello @ assaygenie.comにお問い合わせください。 概観 Acro Bio ...

    Galectin Therapeutics(Post)

    Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis (IPF) is a chronic, irreversible and ultimately fatal disease characterized by pro ...

    Interferons(Post)

    Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

    Waardenburg Syndrome and Klein-Waardenburg Syndrome(Post)

    Waardenburg Syndrome: A Rare Genetic Disorder Affecting Pigmentation, Hearing, and More Waardenburg Syndrome (WS) is a fascinating and rare genetic disorder that impacts various asp ...

    Biological Role of GLP-1(Post)

    Glucagon-like peptide-1 (GLP-1) is a critical hormone in the regulation of glucose metabolism and has garnered significant attention due to its therapeutic potential in managing diabetes ...

    Advice and Guidelines from The Jack Ma Foundation for the Treatment and Prevention of COVID-19(Post)

    COVID-19 Prevention and Treatment What is COVID-19? COVID-19 is an infectious disease caused by the cor ...

    Cellular Respiration: Stages, ATP Production & Pathway Guide(Post)

    Cellular Respiration: Stages, ATP Yield & Pathway Guide | Assay Genie { "@context": "https://schema.org", "@type": "Article", "headline": "Cellular Respiration: St ...

    Fgf Signaling Pathway Explained: Step-by-Step Process & Key Concepts(Post)

    Fibroblast growth factors (FGFs) are pivotal in regulating cellular processes, including proliferation, differentiation, and survival. The FGF signaling pathways play a critical role in embryonic ...

    Understanding T Cell Fatigue: Implications for Immune Function and Therapeutic Interventions(Post)

    T cells are central players in adaptive immunity, responsible for recognizing and eliminating infected or aberrant cells. Upon encountering antigens, T cells undergo clonal expansion and diffe ...

    Innate Lymphoid Cells Differentiation: Guardians of Immune Homeostasis(Post)

    Innate Lymphoid Cells (ILCs) represent a fascinating component of the immune system, playing a crucial role in maintaining tissue homeostasis and mounting rapid responses against pathogens. Th ...

    AKT Signalling – Mini Review(Post)

    Protein kinase B or AKT (PKB) is a serine/threonine kinase. In mammals it is comprised of 3 highly homologous isoforms PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) (Manning and Cantley 2007). AKT ...

    Unveiling the Potential of Cy3 Wavelength: Illuminating the Path to Advanced Biomedical Imaging(Post)

    In the realm of biomedical imaging, the quest for precision and clarity drives researchers to explore innovative technologies. One such breakthrough is the Cy3 wavelength, a powerful tool revo ...

    Pancreatic Cancer and its Poor Prognosis(Post)

    Myrna Hurtado, PhD Student, University of North Texas Health Science Center Advancements in modern medicine have resulted in significantly prolonging and ...

    Cell Synchronisation Methods(Post)

    What is Cell Synchronisation? Cell synchronisation is a process by which cells at different stages of the cell cycle in a culture are brought to the same phase. Cell synchronisation is ...

    Kit di Estrazione DNA RNA Virus (Post)

    Kit di Estrazione DNA/RNA Virus Il Kit di Estrazione dell'Acido Nucleico Virale II è stato progettato specificamente per la purificazione efficiente del DNA virale e dell'RNA vir ...

    Passaging Hybridoma Cells: A Detailed Guide(Post)

    Hybridoma cells are essential tools for producing monoclonal antibodies and are derived by fusing B lymphocytes (antibody-producing cells) with myeloma cells (cancer cells) to achieve bo ...

    Sandwich ELISA: Step-by-Step Protocol & Troubleshooting(Post)

    Written by Seán Mac Fhearraigh, PhD  •  Updated: 19 May 2026  •  ~10 min read Quick Answer A sandwich ELISA uses two antib ...

    Validation of MycoGenie Rapid Mycoplasma Detection Kit - A highly sensitive visual determination method for Mycoplasma detection.(Post)

    The MycoGenie Rapid Mycoplasma Detection Kit enables the detection of 28 Mycoplasma species in under 1 hour using a simple visual determination method, eliminating the need for expensiv ...

    M2 Supplement for Organoid Cell Culture: Enhancing Growth and Differentiation(Post)

    The use of M2 Supplement in organoid culture has revolutionized the way researchers cultivate and maintain these three-dimensional (3D) cellular models. Organoids—self-organizing cell cl ...

    Hippo Pathway Review(Post)

    MST2/Hippo PathwayMammalian Sterile Twenty (MST) pathways have been identified as a homologue of the ste20 kinase from Saccharomyces cerevisiae (Creasy and Chernoff 1995). The MST2/Hippo pathwa ...

    Fluorescence spectroscopy: An early detection tool for cancer.(Post)

    Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early unders ...

    The Ebola Virus: What You Need to Know(Post)

    The Ebola virus has been in the news a lot lately, but many people still don't know what it is or how it spreads. In this blog post, we will discuss the basics of the Ebola virus: w ...

    Phosphorylation: Types, ATP Synthesis & Cell Signalling [Guide](Post)

    Introduction Phosphorylation is a fundamental biochemical process that plays a crucial role in various cellular functions. It involves the addition of a phosphate group to a molecule, typ ...

    Microcalcifications in breast cancer: Novel insights into the molecular mechanism and functional consequences(Post)

    Shane O’Grady, PhD student, RCSI Cancer is a disease that will, unfortunately, touch all of our lives at some point, directly or indirectly. Despite decades ...

    The common characteristics of cancer | Assay Genie(Post)

    By Shane Houston, PhD Candidate Queen’s University Belfast Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health ...

    Platelets : The Unassuming Heroes of Blood Circulation(Post)

    Platelets, the tiny cellular fragments found in our blood, play a crucial role in maintaining our overall health and well-being. From their role in blood clotting to their involveme ...

    Neurofilament Light chain (NEFL) as a biomarker for neuronal damage(Post)

    Delve into the pivotal role of Neurofilament Light chain (NEFL) in neuron structure and its emerging importance as a biomarker for various neurodegenerative diseases, offering insights into di ...

    Enhancing Cancer Research: Syngeneic Mouse Models and Immune Checkpoint Inhibitors(Post)

    Enhancing Cancer Research: Syngeneic Mouse Models and Immune Checkpoint Inhibitors A quick guide to Syngeneic Mouse Models Syngeneic Mouse Models Cancer research has seen rem ...

    Immunophenotyping: A Comprehensive Analysis of Cellular Immune Profiles(Post)

    Immunophenotyping, a cornerstone of modern immunology, involves identifying and characterizing cell populations based on their surface markers. This technique provides insights into the hetero ...

    Apoptosis Assays(Page)

    Assay Genie has developed an extensive suite of assays to measure various forms of cell death. We provide highly sensitive & reprod ...

    ELISA Sampler Packs(Page)

    ELISA Sampler Packs Based on thousands of citations and years of scientific endeavour, Assay Genie has developed ELISA Sampler Packs. An ELISA Sampler Pack is a ...

    Immunohistochemistry (IHC) Buffers & Recipes(Page)

    What is IHC? Immunohistochemistry (IHC) is a valuable tool used for the identification of specific antigens within embedded tissue prepara ...

    細胞溶解用超音波処理プロトコル(Page)

    { "@context" : "http://schema.org", "@type" : "Article", "name" : "細胞溶解用超音波処理プロトコル", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublis ...

    Oxidative Stress Assays(Page)

    Oxidative Stress Assays Simple & Sensitive Assays to Investigate Oxidative Stress! ...

    Citations(Page)

    Product CitationsMore than 1,000 cited products in scientific journalsWe're not just any scientific company; our products have made waves in the scientific community. From groundbreakin ...

    Chemokines(Page)

        Chemokines   Key Research Areas       C Chemokine Ligands XCL1/Lymphot ...

    Multiplex Custom Panels(Page)

    Create your own custom multiplex assay with over 400 analytes to choose from! At Assay Genie we can develop custom assays to meet your research needs within 10 days! To find out more infor ...

    Cell-Based ELISA Kits (Page)

    Cell-Based ELISA Kits No More Western Blots! Over 1,600 Cell-Based ELISA kits to measure the relative levels of intracellular and phosphorylat ...

    Multiplex Premixed Panels(Page)

    window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-08a0a ...

    Human Multiplex ELISA Panels(Page)

    window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-5c77c8b5-9a ...

    DNA Ligation(Page)

    { "@context" : "http://schema.org", "@type" : "Article", "name" : "DNA Ligation", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublishe ...

    T4 DNA Ligase(Page)

    { "@context" : "http://schema.org", "@type" : "Article", "name" : "T4 DNA Ligase", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublishe ...

    Multiplex Assays(Page)

    Multiplex Assays "It’s like doing 24 different ELISA in every well!" GeniePlex Multiplex Assays allow researchers to quantify up to 24 analytes in as little as 15μL of sample ...

    Human Multiplex Inflammation ELISA Panels(Page)

    The ELISA Genie, Human Inflammation multiplex assays utilizes multiple bead populations differentiated by size and different levels of fluorescence intensity. With multiple sizes of bea ...

    Mouse Multiplex ELISA Panels(Page)

    window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-6747133c-26 ...

    PharmaGenie ELISA Kits(Page)

    PharmaGenie ELISA Validated According to ISO Quality Systems Highly validated ELISA designed to exceed the needs of biopharma R&D s ...

    RIPA Buffer Recipe(Page)

    What is RIPA Buffer? RIPA (Radio Immuno Precipitation Assay) buffer is primarily used when conducting a western blot or immunoprecipatation assay. A RIPA buffer is used in order to l ...

    High-Fidelity DNA Polymerase(Page)

    What is DNA Polymerase Fidelity? The fidelity of a DNA polymerase is the result of accurate replication of a desired template. The fidelity of DNA polymerase ...

    COVID-19 Cytokine Storm Multiplex Assays(Page)

    window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-d7cc806f-05 ...

    Adaptive immune system molecules(Page)

    Co-stimulatory and Co-inhibitory Molecules in Adaptive Immunity The adaptive immune system is in part regulated by a vast array of co-stim ...

    Rat Multiplex ELISA Panels(Page)

    window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-08000e48-13 ...

    Subcellular Fractionation Protocol - Mitochrondria, Nuclear, Cytosolic(Page)

    What is Subcellular Fractionation? Subcellular fractionation is the process of iIsolating nuclear, cytosolic and mitochondrial fractions of high purity from tissues. Subcellular fracti ...

    COVID-19 Swab Test(Page)

    window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-3b71d8df-36 ...

    COVID 19 Nasal Swab Test(Page)

    COVID-19 Nasal Swab Test Nasal/Nasopharyngeal Swabs for Viral Sample Collection The developme ...

    RIPA Buffer Recipe - Mandarin(Page)

    { "@context" : "http://schema.org", "@type" : "Article", "name" : "放射免疫沉淀分析 缓冲液配方", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublished" : "202 ...

    Mycoplasma Testing - Detection & Elimination(Page)

    Mycoplasma Testing Mycoplasma Detection & Elimination Kits Visually detect Mycoplasma by eye in 1 hour! View Validation h1.page-heading{ display: ...

    Subcellular Fractionation Protocol - Mandarin(Page)

    { "@context" : "http://schema.org", "@type" : "Article", "name" : "亚细胞分级分离方案", "author" : { "@type" : "Person", "name" : "Sean Mac Fhearraigh" }, "datePublished" : "2 ...

    Molecular Biology(Page)

    document.addEventListener("DOMContentLoaded",(function(){var e=document.querySelector(".page-sidebar");e&&e.remove(),document.querySelectorAll(".page-heading").forEach((function(e){e.re ...

    Site Directed Mutagenesis(Page)

    Key Takeaways: Site-directed mutagenesis (SDM) enables precise DNA sequence alterations. Used for investigating protein activity changes and introducing beneficial mutations. GenieClone ki ...

    Non-Human Primate Multiplex ELISA Panels(Page)

    window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAGE_ELEMENTS || new Array(); window.SHOGUN_IMAGE_ELEMENTS.push({ hoverImage: '', uuid: 's-2dc821cd-c5c ...

    TA Cloning(Page)

    { "@context" : "http://schema.org", "@type" : "Article", "name" : "TA Cloning", "author" : { "@type" : "Person", "name" : "Eimear Nolan" }, "datePublished" ...

Featured