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VEGF: Inflammation and Tumourigenesis(Post)
What is VEGF? Vascular Endothelial Growth Factors (VEGFs) are a group of homodimeric polypeptides, and are master regulators of vascular development, maintenance and a
AKT Signalling – Mini Review(Post)Protein kinase B or AKT (PKB) is a serine/threonine kinase. In mammals it is comprised of 3 highly homologous isoforms PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) (Manning and Cantley 2007). AKT
Subcellular Fractionation Protocol - Mitochrondria, Nuclear, Cytosolic(Page) Girentuximab: Exploring Its Mechanism, Clinical Potential, and Research Advancements(Post)Quick Facts About GirentuximabWhat is Girentuximab?Girentuximab is a monoclonal antibody targeting carbonic anhydrase IX (CAIX), predominantly expressed in renal cell carcinoma (RCC) cel
Sample Dilution Range Calculation for Competitive ELISA kits(Post)Quick answer A competitive ELISA is running correctly when the blank (zero standard) gives the highest OD, the standard curve drops smoothly with rising concentration, and your samples land in the
Interferons(Post)Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and
HIF Repress Pathways: An Insight into Cellular Oxygen Homeostasis(Post)Hypoxia-inducible factors (HIFs) are pivotal in the cellular response to oxygen deprivation. These transcription factors regulate various aspects of cellular and systemic homeostasis in response t
Positive Control vs Negative Control(Post)T cell activation is a crucial process in the immune response, playing a pivotal role in how the body responds to pathogens and maintains immune homeostasis. This intricate process involves severa
Sepsis and Immune Dysregulation(Post)Exploring sepsis: a critical imbalance in the immune response to infection. Key Takeaways: Sepsis is a severe, immune-driven response to infection causing systemic inflammation and potent
Autophagy alterations in Alzheimer’s disease(Post)By Diana-Madalina Stan, PhD student, University of Salford Disease Description Alzheimer’s disease (AD), the most common cause of dementia, is a neu
CD80: Amplifying Immune Activation Through Co-Stimulatory Pathways(Post)Introduction to CD80 and Its Role in Immune Activation CD80 is a critical immune checkpoint molecule that plays an essential role in T cell activation through co-stimulatory pathways. Exp
OKRs for Researchers(Post)Objectives & Key Results Objectives & Key Results (OKRs) is a framework for setting and tracking goals. At Assay Genie, we've tailored this approach to suit researc
Antibody Conjugation: Techniques and Applications(Post)Antibody conjugation is a pivotal technique in biomedical research and diagnostic applications. This process involves the covalent attachment of a molecule, such as a drug, toxin, enzym
CD11b: Macrophages and Microglia Marker(Post)The immune system plays a critical role in defending the body against pathogens and maintaining tissue homeostasis. Within the intricate network of immune cells, CD11b, also known as integ
Enapotamab: Advancing Cancer Research with Innovative Therapeutics(Post)Quick Facts About EnapotamabWhat is Enapotamab?Enapotamab is an experimental antibody-drug conjugate (ADC) developed to target tumor cells selectively, offering new hope in cancer treatm
Lusvertikimab: Unveiling the Potential in Immuno-Oncology(Post)What You Need to Know About LusvertikimabWhat is Lusvertikimab?Lusvertikimab is a monoclonal antibody designed to inhibit the IL-4 receptor, a key player in regulating immune responses,
The Bioelectronic Revolution: How Vagus Nerve Stimulation is Redefining Autoimmune Therapy(Post)Imagine a future where chronic autoimmune diseases, once managed by powerful pharmaceuticals with challenging side effects, are instead calmed by a gentle electrical pulse. This isn't science fiction
Diabetic Retinopathy: premature cellular senescence and microvascular dysfunction(Post)By Pietro Maria Bertelli, PhD Candidate, Queens University Belfast Introduction Eye complications are very frequent in patients with diabetes, and thi
Zilovertamab: Unlocking the Potential of ROR1-Targeted Therapy(Post)Quick Facts About ZilovertamabWhat is Zilovertamab?Zilovertamab is a monoclonal antibody targeting ROR1, a receptor tyrosine kinase overexpressed in hematologic cancers and solid tumors.
Tezepelumab: A Breakthrough in Severe Asthma Treatment and Research(Post)Quick Facts About TezepelumabWhat is Tezepelumab?Tezepelumab is a monoclonal antibody designed to inhibit thymic stromal lymphopoietin (TSLP), a key driver of airway inflammation in seve