10700 results for 'namepl activ'

By Anusha Senevirante, Post-Doctoral researcher, Imperial College London With non-communicable diseases (or NCDs, which include heart disease, diabetes, ca

What is Hepatocyte Growth Factor? Hepatocyte growth factor (HGF) is a cytokine that is mainly produced by the liver. HGF is a pleiotrophic cytokine that regulates cell growth, motilit

In recent years, cancer immunotherapy has become a powerful tool for treating various malignancies. One promising approach involves targeting the tumor microenvironment, particularly regu

Chronic myelogenous leukaemia (CML) is a myeloproliferative haematopoietic malignancy, characterised by a karyotypic abnormality present in more than 95% of cases known as the Philadelph

Cell Biology · Protein DegradationThe Autophagy Pathway: Mechanism, Regulation and How to Measure ItAutophagy is the cell’s route for degrading and recycling its own contents — damaged organelles, agg

Interleukin-21 (IL-21) stands out as a pivotal cytokine in the complex network of immune system communication. Its role in regulating various immune cell types has drawn considerable attention

Quick Facts About RelatlimabWhat is Relatlimab?Relatlimab is a monoclonal antibody that targets LAG-3 (Lymphocyte Activation Gene-3), a key immune checkpoint involved in T-cell regulatio

Regulatory T cells (Tregs) play a crucial role in maintaining immune balance by suppressing excessive immune responses that could lead to tissue damage. However, in the context of cancer,

For decades, we viewed cancer as a rogue army of cells, a biological glitch driven solely by genetic mutations and metabolic greed. We imagined tumors as isolated fortresses, growing in a vacuum of t

Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target fo

Introduction to CD73 and Tumor Immunosuppression CD73, also known as ecto-5'-nucleotidase, is an enzyme found on the surface of various cells, including tumor cells and immune cells. It p

The Spanish flu pandemic of 1918-1919 was the deadliest in history. It is estimated that up to 100 million people died from the virus, which is more than three times the number who d

Phagocytosis is a subtraction, not a switch. A macrophage engulfs when its activating signals exceed its inhibitory ones, and every awkward result in the myeloid checkpoint field falls out of that on

What is Neuroimmunology? Neuroimmunology is a multidisciplinary scientific field dedicated to investigating the intricate and bidirectional interactions between the c

What is pharmacogenomics Pharmacogenomics is how DNA variation and drugs interact and how this can optimise patient health; this involves studying pharmacokinetics and pharmacodynamics.

Quick Facts About MonalizumabWhat is Monalizumab?Monalizumab is a first-in-class immune checkpoint inhibitor targeting NKG2A, developed to enhance anti-tumor immune response by blocking

Quick Facts About PlonmarlimabWhat is Plonmarlimab?Plonmarlimab is a monoclonal antibody targeting GM-CSF, a cytokine involved in inflammation and immune responses.How does Plonmarlimab

By Sonika Singh PhD candidate, University of Nottingham A Devastating Disease Multiple Sclerosis (MS) is a chronic and inflammatory disease based on