132 results for 'HER2'

Quick Facts About TrastuzumabWhat is Trastuzumab?Trastuzumab is a monoclonal antibody used to treat HER2-positive breast and gastric cancers. It specifically targets the HER2 protein, re

Biomarkers, measurable indicators of biological processes or responses to therapeutic interventions, play a pivotal role in modern healthcare. They provide clinicians with valuable information

Quick Facts About ZolbetuximabWhat is Zolbetuximab?Zolbetuximab is a monoclonal antibody that targets Claudin 18.2, a protein overexpressed in gastric and pancreatic cancers, enhancing t

Immunology · Antibody BiologyAntibody Light Chains, Heavy Chains, Constant Regions & Tumour-Associated AntigensAn antibody’s specificity comes from its variable domains and its biological effect comes

Epidermal Growth Factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor epidermal growth factor receptor (EGFR) which triggers ligand-induced d

1. What is a Biosimilar? A biosimilar is a biologic medical product that is highly similar to an already-approved reference biologic. While minor differences in clinically inactive compon

IntroductionThe human kinome is estimated to contain 518 genes, in comparison to the estimated 180 genes that comprise the phosphatome (Arena et al., 2005). These kinase genes represent a signif

Shane O’Grady, PhD student, RCSI Cancer is a disease that will, unfortunately, touch all of our lives at some point, directly or indirectly. Despite decades

The Role of CTLA-4 in Breast Cancer: Implications for ImmunotherapyBreast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, with significant morbidity and mortality

Natural killer (NK) cells are a crucial component of the innate immune system and play a significant role in eliminating tumor cells. Unlike T cells, NK cells can recognize and kill cance

Quick Facts About Ladiratuzumab VedotinWhat is Ladiratuzumab Vedotin?Ladiratuzumab Vedotin is an antibody-drug conjugate (ADC) designed to target LIV-1, a protein commonly expressed in t

Cell Signalling · Growth FactorsGrowth Factors: Families, Receptors and Signalling PathwaysGrowth factors are secreted proteins that instruct cells whether to divide, differentiate, migrate or survive

Cell Signalling · EnzymologyProtein Kinases: Function, Classification, Structure and InhibitorsProtein kinases transfer a phosphate group from ATP onto specific residues of target proteins, switching

Cell Cycle · KinasesCyclins and Cyclin-Dependent Kinases: Regulation, Substrates and Mitotic ControlCDKs are inactive on their own. They require a cyclin partner, and because cyclin levels rise and fa