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    CTLA-4 in Breast Cancer: Insights for Immunotherapy(Post)

    The Role of CTLA-4 in Breast Cancer: Implications for ImmunotherapyBreast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, with significant morbidity and mortalit ...

    Oct-4 Stem Cells(Post)

    Oct-4 stem cells, also known as Octamer-binding transcription factor 4 stem cells, are a fascinating area of study in the field of stem cell research. These stem cells hold great promise due to t ...

    Anti-CTLA-4 Immunotherapy(Post)

    CD Markers Cluster of Differentiation (CD) markers play an important role in the differentiation of B cells, T cells and NK (natural killer) c ...

    4-1BB: Energizing Immune Cells to Overcome Tumor Resistance(Post)

    Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic re ...

    Anti-CTLA-4: Unleashing the Power of T Cells in Combination Immunotherapy(Post)

    Immunotherapy has revolutionized cancer treatment by harnessing the body's immune system to fight malignancies. Among the notable advancements in this field is the development of immune ...

    Ipilimumab and Nivolumab: Advancing Research on CTLA-4 in Cancer Therapy(Post)

    What You Need to Know About IpilimumabWhat is Ipilimumab?Ipilimumab is a monoclonal antibody that targets CTLA-4, a protein involved in downregulating the immune system, to boost the bo ...

    Antigen Presenting Cells (APCs) and cancer immunotherapy(Post)

    Explore antigen presentation's crucial role in adaptive immunity and its impact on cancer immunotherapy, highlighting the diversity and function of MHC class I molecules. Key Takeawa ...

    VEGF: Inflammation and Tumourigenesis(Post)

    What is VEGF? Vascular Endothelial Growth Factors (VEGFs) are a group of homodimeric polypeptides, and are master regulators of vascular development, maintenance and ...

    Hijacking the Skull's Gateways: A New 'Backdoor' for Brain Drug Delivery(Post)

    For decades, the brain has been considered an immune sanctuary, protected by the formidable blood-brain barrier. This intricate defense system, while vital for safeguarding our most complex organ, h ...

    Unraveling the Mysteries of Platelet-Activating GPCR Signaling(Post)

    Platelet activation plays a pivotal role in hemostasis, the process that stops bleeding and initiates wound healing. Central to this process is the activation of G protein-coupled receptors (GPCR ...

    BDNF in inflammation and neuropathologies(Post)

    BDNF Overview Brain-derived neurotrophic factor (BDNF) is a central mediator of neuroplasticity, a term used to describe the ability of neuron ...

    Interleukin-8 signalling(Post)

    IL-8 Overview Interleukin-8 (IL-8), also known as CXCL8, was discovered over 30 years ago as a small molecule that could promote chemotaxis and induce the production ...

    Protease vs Peptidase: Understanding Enzymatic Digestion(Post)

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    Cellular Respiration: Stages, ATP Production & Pathway Guide(Post)

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    Wnt Signalling Pathway in Immunity(Post)

    What is Wnt Signalling? The Wnt signalling pathway is an evolutionarily conserved pathway that plays critical roles in the regulation of determining cell ...

    10 Steps to increase lab productivity(Post)

    How to increase lab productivityWhen you look back at some weeks in the lab it seems like you have achieved nothing and your lab productivity can be low. Your cloning hasn’t worked or your mice ...

    Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer(Post)

    Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Sweet Deception: How a New Antibody Therapy Unmasks Pancreatic Cancer Pancreatic can ...

    The Transformative Era of Induced Pluripotent Stem Cells in Modern Medicine(Post)

    The inception of induced pluripotent stem cells (iPSCs) has heralded a new dawn in the realm of biomedical research and regenerative medicine, setting the stage for groundbreaking advancements in ...

    Lusvertikimab: Unveiling the Potential in Immuno-Oncology(Post)

    What You Need to Know About LusvertikimabWhat is Lusvertikimab?Lusvertikimab is a monoclonal antibody designed to inhibit the IL-4 receptor, a key player in regulating immune responses, ...

    The double-edged sword in prostate cancer therapy(Post)

    By Zoe Angel, PhD Student, Ulster University Prostate cancer is now the commonest cancer in men and it is the fifth leading cause of death (1). Researc ...

    Auto-inflammatory diseases and genetics (SAIDs)(Post)

    Shelly Pathak PhD candidate, University of Leeds SAIDs Systemic Auto-inflammatory diseases (SAIDs) have been defined as a group of mainly inherited disorde ...

    CD155: Breaking Immune Suppression in Tumor Environments(Post)

    Introduction to CD155 in Cancer ImmunotherapyCD155, also known as Poliovirus Receptor (PVR), is a transmembrane protein that plays a pivotal role in tumor immune evasion. While CD155 is ...

    CD80: Amplifying Immune Activation Through Co-Stimulatory Pathways(Post)

    Introduction to CD80 and Its Role in Immune Activation CD80 is a critical immune checkpoint molecule that plays an essential role in T cell activation through co-stimulatory pathway ...

    CD86: Enhancing T Cell Activation in Immunotherapy(Post)

    Introduction to CD86 and Its Role in Immune Activation CD86 is a crucial co-stimulatory molecule that plays an essential role in T cell activation, driving the immune system’s abili ...

    Targeting Immune Checkpoints as Cancer Therapy(Post)

    In recent years, the field of oncology has witnessed a paradigm shift with the advent of immunotherapy, a treatment modality that harnesses the body's immune system to combat cancer. Among the mo ...

    Understanding the Autophagy Pathway: A Critical Process in Cellular Maintenance(Post)

    Autophagy, a fundamental cellular process, is crucial for maintaining cellular homeostasis and responding to various stressors. This self-eating mechanism involves the degradation and recycling o ...

    Utomilumab: Advancing Immuno-Oncology Research(Post)

    Quick Facts About UtomilumabWhat is Utomilumab?Utomilumab is a monoclonal antibody targeting 4-1BB (CD137), a co-stimulatory receptor on T-cells, designed to enhance anti-tumor immunity ...

    Targeting Immune Checkpoints as Cancer Therapy(Post)

    The advent of immune checkpoint targeting marks a significant milestone in the oncological field, offering a beacon of hope for patients battling cancer. This innovative approach leverages the bo ...

    Renal Cell Carcinoma: Understanding, Diagnosing, and Treating Kidney Cancer(Post)

    Renal Cell Carcinoma (RCC) is the most common form of kidney cancer, originating in the lining of the proximal renal tubules. RCC accounts for approximately 90% of all kidney cancers and ...

    Dupilumab: Transforming Immunotherapy and Skin Disease Management(Post)

    What You Need to Know About DupilumabWhat is Dupilumab?Dupilumab is a fully human monoclonal antibody designed to treat various chronic inflammatory diseases by inhibiting key cytokines ...

    Serum vs Plasma: Key Differences & When to Use Each [Guide](Post)

    Sample Preparation · ImmunoassaySerum vs Plasma: Key Differences and When to Use EachSerum and plasma come from the same blood draw but are not interchangeable. One is collected after clotting, the o ...

    Understanding Platelet Activation: A Comprehensive Overview(Post)

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    Ovarian Cancer: Symptoms, Causes, Diagnosis and Treatment(Post)

    Ovarian cancer is the fourth most common cancer in women. Ovarian cancer is when the normal cells in the ovary change and grow to form a tumour. Because the ovaries are located deep ...

    Immunometabolism – A therapeutic perspective(Post)

    What is Immunometabolism? Immunometabolism is an exponentially growing, multi-disciplinary field of research aiming at deciphering the dynamic cellular and mol ...

    Immune-Checkpoint Inhibition in Cancer Prevention(Post)

    Harnessing Immune-Checkpoint Inhibition for Cancer Prevention Immune-checkpoint inhibition (ICI) has emerged as a pivotal strategy in cancer therapy, particularly in the context of t ...

    Enfortumab Vedotin: Unveiling Its Role in Cancer Treatment and the Rise of Biosimilars(Post)

    Quick Facts About EnfortumabWhat is Enfortumab Vedotin?Enfortumab vedotin is an innovative cancer therapy, primarily used in treating urothelial carcinoma (bladder cancer) that has not ...

    Troubleshooting high ELISA concentrations(Post)

    QUICK ANSWER If your ELISA returns sample concentrations that are orders of magnitude too high, the assay itself is usually fine — the error is almost always in data analysis. The mos ...

    TNFRSF9: Enhancing Immune Cell Activity Against Tumors(Post)

    Introduction to TNFRSF9 and Its Role in Immune ActivationTNFRSF9, also known as 4-1BB or CD137, is a co-stimulatory receptor expressed on the surface of T cells, natural killer (NK) cell ...

    3D Organoid Cell Viability Assay: Assessing Environmental Stress on BENOs for Live Delivery(Post)

    3D Organoid Cell Viability Assay (AKES081) effectively measures BENO model viability across different storage conditions. AKES081 detects significant viability differences, particularly ...

    From Stem Cells To Neurons: A Cnidarian Approach(Post)

    By Eleni Chrysostomou, PhD Candidate, NUIG Why do we need to know how the Nervous System develops and regenerates? The structure and function of ...

    ICOS: Stimulating the Immune System for Superior Cancer Therapy(Post)

    Immunotherapy has transformed the landscape of cancer treatment by leveraging the body’s immune system to target and destroy cancer cells. A key player in this process is Inducible T-cel ...

    The Role of Claudins in Cancer (Post)

    Introduction Claudins are a family of proteins that play a critical role in the formation of ...

    TIGIT: A New Frontier in Cancer and Autoimmune Disease Immunotherapy(Post)

    TIGIT (T cell immunoreceptor with Ig and ITIM domains) has emerged as a promising target in cancer immunotherapy and the treatment of autoimmune diseases. As a checkpoint receptor, TIGIT ...

    LILT: A Novel Immune Checkpoint for Cancer Therapy(Post)

    Recent advances in immunotherapy have highlighted the importance of targeting immune checkpoints to enhance the immune system’s ability to combat cancer. A new potential target in this g ...

    Guide to Bacterial Transformation: The Science of Genetic Manipulation(Post)

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    The Battle of Antibiotics: Penicillin vs. Streptomycin(Post)

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    10 Steps of Glycolysis: Enzymes, Diagram & ATP Yield(Post)

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    Embryonic Induced Pluripotent Stem Cell Differentiation: Pathways and Lineage-Specific Markers(Post)

    Embryonic induced pluripotent stem cells (iPSCs) hold immense potential in the field of regenerative medicine due to their ability to differentiate into various cell types. Understanding the diff ...

    Unlocking a New Immune Checkpoint: The CD47-Thrombospondin-1 Pathway in Cancer(Post)

    Cancer immunotherapy has revolutionized oncology, offering powerful new ways to treat various malignancies by harnessing the body's own immune system. Central to this success are immune checkpoint in ...

    The Rat Effectively Models Signature Cytokines of T Helper Cells(Post)

    Understanding the immune system's intricacies requires models that accurately reflect its complexity. The rat, as a model organism, plays a crucial role in immunological research, particularly i ...

    Introducing BioSymposia: The Gathering Place for Science(Post)

    Announcement · Powered by Assay GenieIntroducing BioSymposia: The Gathering Place for ScienceWe’re excited to announce the launch of BioSymposia, our new sister platform and a free home for sc ...

    TNFR2: Taming Regulatory T Cells to Enhance Anti-Tumor Immunity(Post)

    In recent years, cancer immunotherapy has become a powerful tool for treating various malignancies. One promising approach involves targeting the tumor microenvironment, particularly reg ...

    The common characteristics of cancer | Assay Genie(Post)

    By Shane Houston, PhD Candidate Queen’s University Belfast Cancer is an age old adversary of the human race. This out-of-control growth of abnormal cells has been a shadow over human health ...

    Targeting VISTA: Unleashing the Power of T Cells in Cancer Therapy(Post)

    V-domain Ig suppressor of T cell activation (VISTA) is an emerging immune checkpoint receptor that plays a key role in suppressing T cell activity within the tumor microenvironment (TME) ...

    ELISA vs Western Blot: Which Technique Should You Choose?(Post)

    Written by Seán Mac Fhearraigh, PhD  •  Updated: 19 May 2026  •  ~9 min read Quick Answer ELISA and Western Blot are both antibody-based protein detection methods. ELISA is f ...

    GITR: Boosting T Cell Activation for Enhanced Cancer Immunotherapy(Post)

    Glucocorticoid-induced tumor necrosis factor receptor (GITR) is an immune checkpoint molecule that plays a crucial role in regulating T cell activation and survival. In recent years, GIT ...

    CD27 Activation: Strengthening the Immune Army Against Cancer(Post)

    Harnessing the immune system to fight cancer has become a pivotal strategy in modern oncology. A key component in this fight is CD27, a receptor that plays a crucial role in T-cell activ ...

    Sensing Danger: The Biology of TLR-Mediated Inflammation(Post)

    By Eoin Mac Réamoinn Toll-like receptors (TLRs) are renowned for their fundamental roles in innate sensing and initiating inflammatory responses. TLR ...

    How to be a Confident Speaker (Scientific)(Post)

    Like needles in a haystack, interesting speakers that bring charisma and rock n roll to their talks are hard to come by. No matter what the research interests of the audience, these speakers h ...

    Physiological Roles for IL-33 | Assay Genie(Post)

    By Charlotte O'Donnell PhD A role for IL-33 in Barrier Function and Epithelial Wound Healing ...

    Toll-like Receptor Signalling in Neurodegenerative Disease(Post)

    Toll-Like Receptors The innate immune response has come under the spotlight in recent years due to its central role in propagating the pathoge ...

    인터루킨 8 시그널링(Page)

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    cGAS-STING cytosolic DNA sensing(Page)

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    Custom ELISA Kits(Page)

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    Human Multiplex Inflammation ELISA Panels(Page)

    The ELISA Genie, Human Inflammation multiplex assays utilizes multiple bead populations differentiated by size and different levels of fluorescence intensity. With multiple sizes of bea ...

    Human Multiplex ELISA Panels(Page)

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    Mouse Multiplex ELISA Panels(Page)

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    Custom Multiplex Assay(Page)

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    Validated GeniePlex Panels(Page)

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    GeniePlex Validated Panels by Cytometer(Page)

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    Validated Multiplex Panels by Flow Cytometer(Page)

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    CAR-T cell signalling(Page)

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    Adaptive immune system molecules(Page)

    Co-stimulatory and Co-inhibitory Molecules in Adaptive Immunity The adaptive immune system is in part regulated by a vast array of co-stim ...

    RIPA Buffer Recipe(Page)

    What is RIPA Buffer? RIPA (Radio Immuno Precipitation Assay) buffer is primarily used when conducting a western blot or immunoprecipatation assay. A RIPA buffer is used in order to l ...

    Co-Immunoprecipitation (co-IP) Protocol(Page)

    Co-immunoprecipitation Protocol A detailed guide of how Co-IP works, a step by step Co-IP protocol and some hints & tips for your Co-IP workflow! Introductio ...

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    Subcellular Fractionation Protocol - Mitochrondria, Nuclear, Cytosolic(Page)

    What is Subcellular Fractionation? Subcellular fractionation is the process of iIsolating nuclear, cytosolic and mitochondrial fractions of high purity from tissues. Subcellular fracti ...

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