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C-Reactive Protein (CRP): Function, Levels & What They Mean(Post)
Biomarkers · InflammationC-Reactive Protein (CRP): Structure, Function and Clinical UseCRP is the most widely measured marker of inflammation in medicine — fast to rise, fast to fall, and entirely non
NLRP3 Inflammasome and Pyroptosis: Pathway, Function and Assays(Post)The inflammasome is one of the few innate pathways that destroys the cell it activates. A macrophage that assembles NLRP3 has committed to a decision it cannot reverse: a priming signal through TLR4
EGFR Pathway and YAP in Non-Small Cell Lung Cancer(Post)Understanding the EGFR Pathway and YAP in Non-Small Cell Lung CancerThe epidermal growth factor receptor (EGFR) pathway plays a pivotal role in the development and progression of non-small cell lung c
The Role of Zonulin In Intestinal Permeability (Post)Gastroenterology · Barrier BiologyZonulin and Intestinal PermeabilityZonulin is the best-characterised endogenous regulator of intestinal tight junctions — the protein that opens the gut barrier on de
Platelets : The Unassuming Heroes of Blood Circulation(Post)Haematology · HaemostasisPlatelets: Formation, Structure, Activation and Clinical SignificancePlatelets are anucleate fragments shed from megakaryocytes, and they carry out primary haemostasis — adher
Unraveling the Synergy: How Growth Factors Cooperate to Promote Tumorigenesis(Post)In the intricate ballet of cellular communication and regulation, growth factors play pivotal roles in guiding the processes of cell growth, division, and differentiation. These proteins are essen
Cytokine Storms: What happens when the immune system overreacts?(Post)Immunology · HyperinflammationCytokine Storm and Cytokine Release Syndrome: Mechanisms, Triggers and MarkersA cytokine storm is a self-amplifying inflammatory response in which cytokine release drives
Protein Kinases: Overview, Classification and Therapeutic Potential(Post)Cell Signalling · EnzymologyProtein Kinases: Function, Classification, Structure and InhibitorsProtein kinases transfer a phosphate group from ATP onto specific residues of target proteins, switching
Two Asthma Drugs, Opposite Eosinophil Counts, Both Working(Post)Two asthma biologics have opposite effects on the blood eosinophil count, and both of them work. Mepolizumab empties the eosinophil compartment; dupilumab can transiently raise it. If that seems cont
Granulocytes: Neutrophils, Eosinophils, Basophils & Mast Cells(Post)Immunology · Myeloid CellsGranulocytes: Neutrophils, Eosinophils and BasophilsGranulocytes are the leukocytes with cytoplasmic granules and lobed nuclei — neutrophils, eosinophils and basophils. They
Build a science blog to progress your career(Post)What do scientists consider their skill set when looking for jobs outside of academia? Mine where hard to sum. I was a PhD in cell biology. I could Western Blot, I had used thousands of anti
COVID-19's Impact on Brain Aging and Cognitive Decline(Post)Impact of COVID-19 on Brain Aging and Cognitive DeclineThe COVID-19 pandemic has had profound effects on various aspects of human health, including mental health. A recent study involving nearly 1,000
Auto-inflammatory diseases and genetics (SAIDs)(Post)Shelly Pathak PhD candidate, University of Leeds SAIDs Systemic Auto-inflammatory diseases (SAIDs) have been defined as a group of mainly inherited disorder
RIPA Buffer Recipe - Cell Lysis | Assay Genie(Post)RIPA (Radio Immuno Precipitation Assay) buffer is mostly used when carrying out a western blot or immunoprecipatation assay. A RIPA buffer is used in order to lyse cells and extract protein fro
Sekundärantikörper wählen: Die Regel, die im Labor wirklich zählt(Post)Sekundärantikörper wählen: Die Regel, die im Labor wirklich zählt Wählen Sie einen Sekundärantikörper, der exakt gegen die Wirtsspezies und Klasse Ihres Primärantikörpers gerichtet ist, hoch-kreuzads
Clinical Pathology Labs List: Overview, Services, and Importance(Post)Clinical pathology labs play a crucial role in modern healthcare, providing critical diagnostic testing services for a wide array of diseases and conditions. These laboratories are design
CTLA-4 in Breast Cancer: Insights for Immunotherapy(Post)The Role of CTLA-4 in Breast Cancer: Implications for ImmunotherapyBreast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, with significant morbidity and mortality
Gut Fungi's Impact on Neurodegenerative Diseases(Post)Exploring the Role of Gut Fungi in Neurodegenerative Diseases Neurodegenerative diseases, including dementia, represent a significant challenge to global health. Recent research has begun to uncover
Interleukin-8 signalling(Post)IL-8 Overview Interleukin-8 (IL-8), also known as CXCL8, was discovered over 30 years ago as a small molecule that could promote chemotaxis and induce the production
The Role of APOE in Neurodegenerative Diseases(Post)Understanding the Role of APOE in Neurodegenerative DiseasesRecent findings reveal that a specific gene variant, APOE, significantly increases the risk of Alzheimer's and Parkinson's diseases, highlig