Description
system_update_altDatasheet
| Product Name: | anti--Mouse CD3z (CD247) monoclonal antibody (FITC) |
| Product Code: | AGIM0517 |
| Size: | 100 µL |
| Reactivity: | Mouse |
| Clone: | H146-968 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG2?? |
| Host Species: | Hamster |
| Storage: | Stable at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P20963 |
| UniProt Protein Function: | CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24.2 Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex Molecular Function:identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity Biological Process: regulation of immune response; viral reproduction; T cell costimulation; innate immune response; T cell receptor signaling pathway; regulation of defense response to virus by virus Disease: Immunodeficiency 25 |
| NCBI Summary: | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20963 |
| NCBI GenInfo Identifier: | 4557431 |
| NCBI Gene ID: | 919 |
| NCBI Accession: | NP_000725.1 |
| UniProt Secondary Accession: | P20963,Q5VX13, Q8TAX4, B1AK49, |
| UniProt Related Accession: | P20963,A46461 |
| Molecular Weight: | 18,696 Da |
| NCBI Full Name: | T-cell surface glycoprotein CD3 zeta chain isoform 2 |
| NCBI Synonym Full Names: | CD247 molecule |
| NCBI Official Symbol: | CD247Â Â |
| NCBI Official Synonym Symbols: | T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETAÂ Â |
| NCBI Protein Information: | T-cell surface glycoprotein CD3 zeta chain; CD3zeta chain; TCR zeta chain; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3 |
| UniProt Protein Name: | T-cell surface glycoprotein CD3 zeta chain |
| UniProt Synonym Protein Names: | T-cell receptor T3 zeta chain |
| UniProt Gene Name: | CD247Â Â |
| UniProt Entry Name: | CD3Z_HUMAN |
