ATG9B Antibody is a rabbit polyclonal antibody directed against ATG9B, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human and Rat. Purified by Peptide Affinity.
ATG9B is a transmembrane protein essential for autophagy, a cellular degradation pathway critical for maintaining neuronal health. It plays a central role in the formation of cytoplasm-to-vacuole transport (Cvt) vesicles and the organization of the preautophagosomal structure (PAS), the nucleation site for autophagosome biogenesis. By regulating membrane trafficking to the phagophore assembly site, ATG9B ensures the proper initiation and progression of autophagy. In the context of neuroscience, ATG9B is gaining attention for its potential role in neurodegenerative disease mechanisms. Autophagy dysfunction is a hallmark of disorders such as Alzheimer’s, Parkinson’s, and Huntington’s disease, where impaired clearance of protein aggregates and damaged organelles contributes to neuronal loss. ATG9B’s involvement in early autophagosome formation positions it as a critical factor in maintaining neuronal proteostasis and synaptic integrity. Although ATG9B is highly expressed in the placenta and pituitary gland, its functional relevance in the central nervous system is increasingly recognized. Emerging studies suggest that modulating ATG9B activity could enhance autophagic flux and mitigate neurodegenerative pathology. Given its upstream role in autophagy and potential impact on neuronal survival, ATG9B represents a promising target for therapeutic intervention in neurodegenerative diseases. Ongoing research aims to elucidate its regulatory mechanisms and interactions within neural tissue. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
