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Bispecific In Vivo Antibodies

Bispecific Antibodies

Anti-Mouse & Anti-Human In Vivo Antibodies

Assay Genie provides high-quality, low-endotoxin (<1 EU/mg) anti-mouse and anti-human bispecific antibodies designed for immune checkpoint modulation, signalling pathway targeting, and immune effector cell engagement. Example target combinations include PD-1/PD-L1, PD-1/TIGIT PD-1/VEGF-A, CD370/PD-L1 & more.


hdr_strong   Immune checkpoint BsAbs
Bispecific antibody immune-checkpoint targets include PD-1/PD-L1, PD-1/CTLA-4, PD-1/TIGIT, and additional emerging combinations.
toll   Immune Cells BsAbs
Bispecific antibodies for immune effector cell engagement include targets such as CD370/PD-L1, CD370/CD47, and CD3/CD3
alt_route   Signalling Pathway BsAbs
Signalling-pathway bispecific antibodies targets include PD-1/VEGF-A, PD-L1/VEGF-A, PD-1/VEGFR-2, and PD-L1/VEGFR-2.
biotech   Custom BsAbs
Design antibodies tailored to your targets and applications, with custom formats for both research and development.


Industry Leading Quality

High Purity & Low Endotoxin Antibodies


check_circle   Low Endotoxin format (<1 EU/mg) 
Low Endotoxin levels (≤ 1.0 EU/mg) and no detectable leachable protein A or aggregates.
check_circle    LALAPG-mutated BsAbs
The mutation significantly reduces Fc-mediated effector functions while keeping affinity and stability intact.
check_circle   High Purity (<95%)
No preservatives, stabilisers or carrier protein. Sterile PBS free from K+ or Ca2+.
check_circle   Comprehensive
30+ functional-grade bispecific antibodies & isotype controls for all applications 

A: Endotoxin Analysis
Endotoxin ≤ 0.5 EU/mg for all 8 lots.
C: Non-reducing SDS Page
Non-reducing SDS-PAGE analysis demonstrating consistently high purity for all lots.
B: Chromataography Analysis
Size exclusion chromatography visualized by superimposing chromatograms for nine lots.
D: Reducing SDS Page
Reducing SDS-PAGE analysis demonstrates consistently high purity for all lots.

Our Custom Bispecific Antibody service is built around your research goals. We design a tailored production strategy to generate high-quality antibodies optimized for in vivo use - whether for preclinical studies, therapeutic research, or animal models. Every step is guided by your targets, your timelines, and our expert scientific support.
search   Project Feasability 
Determine if the target antigen and project objectives are suitable for in vivo antibody generation
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biotech   Bispecific Antibody design
Develop a custom production strategy tailored to the target and research applications
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done_outline   Bispecific Antibody Generation
Generate a robust antibody response or isolate antibody-producing cells using in vivo systems
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assignment_turned_in   Validation & Production
Generate, purify, and deliver functional antibodies


Bispecific Antibody Targets

Designed to support your research

Product
Reactivity
Clone
Application
Anti-mouse PD-1 / PD-1 Bispecific Antibody [RMP1-14.1 / 29F.1A12.1] In Vivo - Low Endotoxin (IVMS002)

Mouse

RMP1-14.1 / 29F.1A12.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / PD-1 Bispecific Antibody [29F.1A12.1 / RMP1-14.1] In Vivo - Low Endotoxin (IVMS003)

Mouse

29F.1A12.1 / RMP1-14.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / PD-L1 Bispecific Antibody [RMP1-14.1 / 10F.9G2.1] In Vivo - Low Endotoxin (IVMS004)

Mouse

RMP1-14.1 / 10F.9G2.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-L1 / PD-1 Bispecific Antibody [10F.9G2.1 / RMP1-14.1] In Vivo - Low Endotoxin (IVMS005)

Mouse

10F.9G2.1 / RMP1-14.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-L1 / PD-1 Bispecific Antibody [10F.9G2.1 / RMP1-14.1] In Vivo - Low Endotoxin (IVMS006)

Mouse

10F.9G2.1 / RMP1-14.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-L1 / PD-1 Bispecific Antibody [10F.9G2.1 / 29F.1A12.1] In Vivo - Low Endotoxin (IVMS006)

Mouse

10F.9G2.1 / 29F.1A12.1
ELISA, WB, FC, IHC, ICC, animal model study
In Vivo Grade Recombinant Anti-mouse PD-L1 / CTLA-4 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone UC10-4F10-11 / 10F.9G2.1) (IVMS030)

Mouse

UC10-4F10-11 / 10F.9G2.1
ELISA, WB, FC, IHC, ICC, animal model study
In Vivo Grade Recombinant Anti-mouse PD-L1 / CTLA-4 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10F.9G2.1 / UC10-4F10-11) (IVMS031)

Mouse

10F.9G2.1 / UC10-4F10-11
ELISA, WB, FC, IHC, ICC, animal model study
In Vivo Grade Recombinant Anti-mouse PD-1 / TIGIT Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 29F.1A12.1 / 1F4) (IVMS032)

Mouse

29F.1A12.1 / 1F4
ELISA, WB, FC, IHC, ICC, animal model study
Product
Reactivity
Clone
Application
Anti-mouse CD370 / PD-L1 Bispecific Antibody [10B4 / 10F.9G2.1] In Vivo - Low Endotoxin (IVMS008)

Mouse

10B4 / 10F.9G2.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse CD370 / CD47 Bispecific Antibody [10B4 / A4] In Vivo - Low Endotoxinn (IVMS009)

Mouse

10B4 / A4
ELISA, WB, FC, IHC, ICC, animal model study
Anti-Human CD3 / CD3 Bispecific Antibody [OKT3 / UCHT1] In Vivo - Low Endotoxin(IVMS027)

Human

OKT3 / UCHT1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-Human CD3 / CD3 Bispecific Antibody [OKT3 / SP34-2] In Vivo - Low Endotoxin(IVMS028)

Human

OKT3 / SP34-2
ELISA, WB, FC, IHC, ICC, animal model study
Product
Reactivity
Clone
Application
Anti-mouse PD-1 / VEGF-A Bispecific Antibody [RMP1-14.1 / B20-4.1.1.1] In Vivo - Low Endotoxin (IVMS0010)
Mouse
RMP1-14.1 / B20-4.1.1.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGF-A Bispecific Antibody [29F.1A12.1 / B20-4.1.1.1] In Vivo - Low Endotoxin (IVMS0010)
Mouse
29F.1A12.1 / B20-4.1.1.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGF-A Bispecific Antibody [29F.1A12.1 / B20-4.1.1.1] In Vivo - Low Endotoxin (IVMS0011)
Mouse
29F.1A12.1 / B20-4.1.1.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-L1 / VEGF-A Bispecific Antibody [10F.9G2.1 / B20-4.1.1.1] In Vivo - Low Endotoxin (IVMS0012)
Mouse
29F.1A12.1 / B20-4.1.1.1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGF-A Bispecific Antibody [RMP1-14.1 / G6-23] In Vivo - Low Endotoxin (IVMS0013)
Mouse
RMP1-14.1 / G6-23
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGF-A Bispecific Antibody [29F.1A12.1 / G6-23] In Vivo - Low Endotoxin (IVMS0014)
Mouse
29F.1A12.1 / G6-23
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-L1 / VEGF-A Bispecific Antibody [10F.9G2.1 / G6-23] In Vivo - Low Endotoxin (IVMS0001)
Mouse
10F.9G2.1 / G6-23
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGF-A Bispecific Antibody [RMP1-14.1 / G6-31] In Vivo - Low Endotoxin (IVMS0015)
Mouse
RMP1-14.1 / G6-31
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGF-A Bispecific Antibody [29F.1A12.1 / G6-31] In Vivo - Low Endotoxin (IVMS0016)
Mouse
29F.1A12.1 / G6-31
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-L1 / VEGF-A Bispecific Antibody [10F.9G2.1 / G6-31] In Vivo - Low Endotoxin (IVMS0017)
Mouse
10F.9G2.1 / G6-31
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGFR-2 Bispecific Antibody [RMP1-14.1 / DC101] In Vivo - Low Endotoxin (IVMS0018)
Mouse
RMP1-14.1 / DC101
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-1 / VEGFR-2 Bispecific Antibody [29F.1A12.1 / DC101] In Vivo - Low Endotoxin (IVMS0019)
Mouse
29F.1A12.1 / DC101
ELISA, WB, FC, IHC, ICC, animal model study
Anti-mouse PD-L1 / VEGFR-2 Bispecific Antibody [10F.9G2.1 / DC101] In Vivo - Low Endotoxin (IVMS0020)
Mouse
10F.9G2.1 / DC101
ELISA, WB, FC, IHC, ICC, animal model study
Product
Reactivity
Isotype
Application
Anti-HEL / HEL Mouse IgG1 Bispecific Isotype Control Antibody In Vivo - Low Endotoxin (IVMS0021)
Mouse
IgG1
ELISA, WB, FC, IHC, ICC, animal model study
Anti-HEL / HEL Mouse IgG2a Bispecific Isotype Control Antibody In Vivo - Low Endotoxin (IVMS0022)
Mouse
IgG2a
ELISA, WB, FC, IHC, ICC, animal model study
Anti-HEL / HEL Mouse IgG2c-LALAPG Kappa Bispecific Isotype Control Antibody In Vivo - Low Endotoxin (IVMS0023)
Mouse
IgG2c
ELISA, WB, FC, IHC, ICC, animal model study
Human IgG1 Bispecific Isotype Control Antibody In Vivo - Low Endotoxin (IVMS0024)
Human
IgG1
ELISA, WB, FC, IHC, ICC, animal model study
Human IgG4-S228P Bispecific Isotype Control Antibody In Vivo - Low Endotoxin (IVMS0025)
Human
IgG4-S228P
ELISA, WB, FC, IHC, ICC, animal model study
Human IgG4-S228P Bispecific Isotype Control Antibody In Vivo - Low Endotoxin (IVMS0025)
Human
IgG4-S228P
ELISA, WB, FC, IHC, ICC, animal model study
Anti-HEL / HEL VHH Mouse IgG2c-LALAPG Kappa Bispecific Isotype Control Antibody In Vivo - Low Endotoxin (IVMS0026)
Mouse
IgG2c-LALAPG Kappa
ELISA, WB, FC, IHC, ICC, animal model study

Contact Form

Send us a quick message with your project details, and a member of our team will follow up to assess feasibility and guide you through the next steps!

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Optimized to achieved the best results

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donut_large   VivoGenie Biosimilar Antibodies
Explore our In vivo grade mAbs engineered to replicate reference biologics.


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Fast Delivery

7 - 10  Business Day Lead Time after Manufacture
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Highly Cited

We develop high quality custom multiplex assays using the best technology
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PhD Level Support

Our team are trained to a PhD level to support your multiplex assay problems


Frequently asked questions


Customers may place an order in 3 ways. Orders can be made online via pro-forma invoice, on our website, or via email by emailing orders@assaygenie.com. If you wish to send a purchase order, you can find our company under "Assay Genie" or "Reagent Genie Ireland Ltd" on your ordering system. Alternatively, orders may be placed via your local distributor.
Our company can be found under the supplier name "Assay Genie" or "Reagent Genie Ireland Ltd." Still can't find us? Check if we are on your vendor system here. If not, we would be happy to fill out a new supplier form to be registered as a vendor. Alternatively, orders can be placed through your local distributor.
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Inquiries can be made online via our 'Contact Us' page. You may also contact us via email at: info@assaygenie.com or orders@assaygenie.com, or by telephone on: +353 15639720. Alternatively, an inquiry can be made via your local distributor.
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Once we have received your order a confirmation email will be sent to you. Details such as order number and estimated date of delivery will also be disclosed in this email.


Meet Some of the Genie Team!

At Assay Genie, we're here to help every step of the way. Whether you need guidance choosing the right product, updates on your order, or expert support after your purchase, we've got you covered.

  • Colm PhD, CEO
    Sean PhD, CSO
    Shane MSc, Sales Manager
    Beatriz, Logistics
  • David PhD, Partner Manager
    Marina PhD, Tech Support
    Joe MSc, Sales
    Miren PhD, Product Manager
  • Zac MSc, Operations Manager
    Natalia PhD, Tech Support
    José MSc, Development Manager

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